Biological activity and toxicity of the Chinese herb <Emphasis Type="Italic">Magnolia officinalis</Emphasis> Rehder &amp; E. Wilson (Houpo) and its constituents

Traditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark of Magnolia officinalis Rehder & E. Wilson, known under the pinyin name “Houpo”, has been traditionally used in Chinese and Japanese medicines for the treatment of anxiety, asthma, depression, gastrointestinal disorders, headache, and more. Moreover, Magnolia bark extract is a major constituent of currently marketed dietary supplements and cosmetic products. Much pharmacological activity has been reported for this herb and its major compounds, notably antioxidant, anti-inflammatory, antibiotic and antispasmodic effects. However, the mechanisms underlying this have not been elucidated and only a very few clinical trials have been published. In vitro and in vivo toxicity studies have also been published and indicate some intriguing features. The present review aims to summarize the literature on M. officinalis bark composition, utilisation, pharmacology, and safety.     

Mechanical determinants of acceleration and maximal sprinting speed in highly trained young soccer players

Abstract

The aim of the present study was to examine, in highly trained young soccer players, the mechanical horizontal determinants of acceleration (Acc) and maximal sprinting speed (MSS). Eighty-six players (14.1 ± 2.4 year) performed a 40-m sprint to assess Acc and MSS. Speed was measured with a 100-Hz radar, and theoretical maximal velocity (V₀), horizontal force (F₀) and horizontal power (P_max) were calculated. Within each age group, players were classified as high Acc/fast MSS (>2% faster than group mean), medium (between ?2% and +2%), and low/slow (>2% slower). Acc and MSS were very largely correlated (?0.79; 90% confidence limit [?0.85; ?0.71]). The determinants (multiple regression r² = 0.84 [0.78; 0.89]) of Acc were V₀ (partial r: 0.80 [0.72; 0.86]) and F₀ (0.57 [0.44; 0.68]); those of MSS (r² = 0.96 [0.94; 0.97]) were V₀ (0.96 [0.94; 0.97]) and P_max (0.73 [0.63; ?0.80]). High/Med have likely greater F₀ (Cohen’s d: +0.8 [0.0; 1.5]), V₀ (+0.6 [?0.1; 1.3]) and P_max (+0.9 [0.2; 1.7]) than Low/Med. High/Fast have an almost certainly faster V₀ (+2.1 [1.5; 2.7]) and a likely greater P_max (+0.6 [?0.1; 1.3]) than High/Med, with no clear differences in F₀ (?0.0 [?0.7; 0.6]). Speed may be a generic quality, but the mechanical horizontal determinants of Acc and MSS differ. While maximal speed training may improve both Acc and MSS, improving horizontal force production capability may be efficient to enhance sprinting performance over short distances.     

The Future of Book Publishing: Seven Technology Trends and Three Industry Goals

The Publishing Industry, as many other ones, is facing all the risks and opportunities linked to a digital transformation. This text provides new dimensions for analyzing seven technological trends and their potential impacts on the book publishing industry. The key consideration is that book publishing is totally dependent on Open Web Platform future. In such an agile environment, the publishing industry should focus on three key objectives in order to keep or even extend its influence on the internet world.