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排序方式: 共有148条查询结果,搜索用时 15 毫秒
81.
S. K. Pandey S. Pandey R. M. Mishra M. Indurkar 《Indian journal of clinical biochemistry : IJCB》2017,32(1):103-105
Normal iron levels are required to prevent thrombocytosis by inhibiting thrombopoiesis. Thrombocytosis is usually associated with a mild iron deficiency and is the result of a lack of inhibition of thrombopoiesis. Study participants were 430 iron deficiency anemia (IDA) patients. Ten (10) mL of venous blood were collected for the subjects. Ferritin analysis was done by ELISA method while Hemogram analysis was done by auto-analyzer. Factor V Leiden, PRTG20210A, and MTHFR C677T genotype analysis was performed by PCR–RFLP method. Among the patients, 9 were heterozygous (G>A) and 2 were homozygous (A>A) carrier of FV Leiden; while 20 were heterozygous (C>T) and 3 were homozygous (T>T) for MTHFR polymorphism. None of the patient was identified with PT mutation. Patients with thrombosis gene marker had lower hemoglobin, mean corpuscular volume, mean corpuscular haemoglobin levels, and mean corpuscular hemoglobin concentration than patients without thrombosis gene marker. Serum ferritin was elevated in subject with the absence of thrombosis gene markers. Our data suggest a high impact of inherited hypercoagulability risk factors in the pathogenesis of IDA and its complications. 相似文献
82.
K. K. Mishra H. P. Pandey R. H. Singh 《Indian journal of clinical biochemistry : IJCB》1993,8(1):26-28
Present study, involved two groups of chronic stress disorders, e.g. bronchial asthma and rheumatoid arthritis. Clinical investigations were launched on the blood samples of human subjects in which the levels of plasma cortisol, blood glucose, total plasma protein and serum cholesterol were assayed in diseased and normal control subjects. Observations in-vitro exhibited a notable change in the levels of all the biochemical parameters in patients of chronic disorders with respect to those of normal controls. The biochemical changes in asthmatics were comparatively more pronounced than those of rheumatoid arthritis patients. It reveals that bronchial asthma is an acute and early onset disorder because with chronicity of stressful events, there is a decline in stress response since hypothalamo-pituitary-adrenal (HPA) axis is not so competent to undergo major remodelling of its circuitry necessary for homeostatic maintanence. 相似文献
83.
Abbas Ali Mahdi Anu Chandra Raj Kumar Singh Sanjeev Shukla L. C. Mishra Sohail Ahmad 《Indian journal of clinical biochemistry : IJCB》2003,18(2):8-15
In the present study the antioxidative potential ofMomordica charantia, Azadirachta indica, Allium sativum andOcimum sanctum was assessed in streptozotocin induced diabetic rats. Lipid peroxide levels were also measured in normal, diabetic and treated
animals. Malondialdehyde (MDA) levels were significantly higher and antioxidant activity was found low in diabetic groups
as compared to the control groups, and significant alteration in both the MDA levels and antioxidant activity was also observed
when the above herbal hypoglycemic agents were given to diabetic rats. On the basis of our results we conclude thatM. charantia, A. indica, A. sativum andO. sanctum are not only useful in controlling the lipid peroxide levels but are also helpful in further strengthening the antioxidant
potential. 相似文献
84.
Rashmi Raghuvanshi Aiki Kaul Pushpa Bhakuni Aparna Mishra M. K. Misra 《Indian journal of clinical biochemistry : IJCB》2007,22(2):90-92
In the present communication, we report remarkably elevated levels of xanthine oxidase activity in the blood of the patients
with myocardial infarction when compared to age and sex matched healthy persons. Highly significant increase of malondialdehyde,
serving as an index of lipid peroxidation and thus free radical mediated damage, has also been found in the patients. We propose
the measurement of the blood levels of xanthine oxidase, a very simple, reliable and less time consuming method as an indicator
of myocardial infarction. 相似文献
85.
K. P. Mishra Navita Sharma Poonam Soree R. K. Gupta Lilly Ganju S. B. Singh 《Indian journal of clinical biochemistry : IJCB》2016,31(1):81-86
High altitude hypoxia is known to induce an inflammatory response in immune cells. Hypoxia induced inflammatory chemokines may contribute to the development of high altitude pulmonary edema (HAPE) by causing damage to the lung endothelial cells and thereby capillary leakage. In the present study, we were interested to know whether chronic inflammation may contribute to HAPE susceptibility. We examined the serum levels of macrophage inflammatory protein-1α (MIP-1α), monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 in group (1) HAPE Susceptible subjects (n = 20) who had past history of HAPE and group (2) Control (n = 18) consist of subjects who had stayed at high altitude for 2 years without any history of HAPE. The data obtained confirmed that circulating MCP-1, MIP-1α were significantly upregulated in HAPE-S individuals as compared to the controls suggestive of chronic inflammation. However, it is not certain whether chronic inflammation is cause or consequence of previous episode of HAPE. The moderate systemic increase of these inflammatory markers may reflect considerable local inflammation. The existence of enhanced level of inflammatory chemokines found in this study support the hypothesis that subjects with past history of HAPE have higher baseline chronic inflammation which may contribute to HAPE susceptibility. 相似文献
86.
Joya Ghosh T. K. Mishra Y. N. Rao S. K. Aggarwal 《Indian journal of clinical biochemistry : IJCB》2006,21(1):181-184
Coronary artery disease is a major cause of morbidity and has various risk factors. Lipid profile i.e. low HDL-cholesterol,
high LDL cholesterol, high total cholesterol, high triglycerides playing important role in its causation. Recently interest
has been shown in the oxidized fraction of LDL as one of the risk factors. In the present study 60 age and sex matched normal
healthy individuals were taken as controls and 60 patients of CAD were taken. Cholesterol was measured by enzymatic method,
HDL cholesterol by phosphotungstate precipitation method. Serum levels of LDL fraction of cholesterol was measured by a new
and simpler method of precipitation. Result was expressed as mol/L of diene conjugates. It was observed that LDL cholesterol,
VLDL cholesterol, total cholesterol, total cholesterol: HDL cholesterol, LDL cholesterol: HDL cholesterol were significantly
raised and HDL cholesterol was significantly low in patients. (p<0.001). Though HDL cholesterol was significantly raised in
females as compared to males in both the groups (p<0.001). Serum level of total cholesterol, oxidized LDL:HDL cholesterol
were also raised significantly (p<0.05). The level of oxidized LDL showed an increasing trend in patients. 相似文献
87.
Anjali C. Warrier Narasimha Y. Rao Devdutta S. Kulpati Tarun K. Mishra Bhaskar C. Kabi 《Indian journal of clinical biochemistry : IJCB》1995,10(1):9-13
There was increase in erythrocyte lipid peroxidation and adenosine deaminase (ADA) activity in red blood cells (RBC's), white
blood cells (WBC's) and plasma, in 30 patients of confirmed diabetes mellitus, 10 each of insulin dependent diabetes mellitus
(IDDM or type I), non-insulin dependent diabetes mellitus (NIDDM or type II) and diabetes with ketoacidosis when compared
with 20 healthy individuals (controls). Glycosylated hemoglobin A1c%, plasma free fatty acid (FFA) and glycerol levels were
also elevated in all the cases when compared with controls. The increase was more in diabetic ketoacidosis group. Significant
positive correlations were seen between erythrocyte lipid peroxidation and ADA activities in RBC's, WBC's and plasma. It is
suggested that decreased tissue adenosine levels due to increase in ADA activity, is related to the severity of hyperglycemia
and lipid peroxidation in diabetes mellitus. 相似文献
88.
89.
The purpose of this study was to provide an empirical basis for the interpretation of the WISC-R performance of Navajo children according to the Luria-Das Model of Simultaneous and Successive cognitive processes. Two groups of Native American Navajo subjects, 45 learning disabled and 41 gifted, were given the WISC-R. The scores on those subtests expected to involve Successive and Simultaneous processes were factor analyzed for each group and two factors were extracted. The factors, essentially similar for both samples, were interpreted to reflect the Successive and the Simultaneous modes of processing information as suggested by the Luria-Das Model. The gifted and learning disabled children had disparate loadings for some of the subtests, suggesting that the two groups may be using distinct modes of coding information. 相似文献
90.
Shitala P. Mishra 《Psychology in the schools》1980,17(1):117-122
The study investigated the effect of examiners' ethnicity on the intelligence test performance of Anglo and Mexican-American subjects. Two verbal subtests of the WISC and the Raven Progressive Matrices, a nonverbal intelligence test, were administered by two Anglo and two Mexican-American examiners. All subjects (N=96) were given half the items of each test by an Anglo and half by a Mexican-American examiner. On two of the three tests, the subjects' performance was unaffected by examiner's ethnic attributes. On the WISC Vocabulary, however, Mexican-American subjects scored significantly higher when the test was administered by Mexican-American examiners. The generalizability of these results and their implications for learning in schools are discussed. 相似文献