Standardization of a dilution method for cyclosporin (C2) estimation in renal transplant patients

Accurate monitoring of blood cyclosporin C2 levels is vital to prevent over immunosuppression and acute renal toxicity in patients who receive organ transplant. The matrix used to dilute patients’ C2 samples prior to the assay affected the final measured values. Hence there was a need to develop a method of dilution that would accurately estimate C2 levels when cyclosporin levels were beyond the calibration range of the method employed. Whole blood, cyclosporin free hemolysate and cell and protein free supernatant obtained after pretreatment of normal blood were used to dilute patients’ C2 samples. C2 was measured in 188 patients using the supernatant method of dilution. C2 was correlated with Co and dose of cyclosporin received by the patient. The use of cell and protein free supernatant obtained after pretreatment of normal blood as a C2 diluent detected higher levels of C2 in the sample. Measured C2 correlated significantly with Co and the cyclosporin dose received by the patient. The uniformly aqueous cell and protein free supernatant ensures uniform dilution of the patients’ C2 sample and measures higher cyclosporin levels.     

本体论在公共部门知识管理体系中的应用探析

提出了本体论对公共部门知识管理体系构建的必要性,并基于本体论探讨公共部门知识管理体系的构建,包括知识发现、知识录入、知识检索模块的建立,以及知识管理体系中智能代理服务的构建。     

膜蛋白三维结构研究的新突破——线粒体呼吸链膜蛋白复合物II结构解析

由清华大学-中科院生物物理所结构生物学联合研究小组完成的"线粒体呼吸链膜蛋白复合物Ⅱ的晶体结构"研究成果以Article的方式发表在2005年7月1日出版的Cell上.本文介绍了该项成果的研究背景、意义、主要创新点及方法.     

三种自然科学学报的文献计量比较：兼论数学研究的特点

本文选择《数学学报》、《物理学报》和《化学学报》为统计样本,对3种学报1986—1990年间3073篇学术论文的参考文献各项指标、合著类型、基金资助论文情况,以及论文的地域分布和机构分布作了比较研究。在此基础上,进一步探讨了数学研究的特点,并提出对促进我国数学研究发展有益的3点启示。     

Confronting poverty and educational inequalities: Madrasas as a strategy for contesting dominant literacy in rural Bangladesh

In a context of globalisation and the rapid expansion of low-paid ‘global’ jobs, formal schooling is no longer perceived as contributing to the acquisition of skills that are appropriate or even relevant to active engagement with the new opportunities. Based on empirical material from a village in Bangladesh, this paper explores the role of madrasa education in challenging the dominant paradigm of learning embedded in formal secular schooling. Despite charges of low quality and traditionalism, local narratives reveal how madrasa learning is used to negotiate and transform inequalities, both in material and social terms. Madrasa education is cheaper, and addresses issues of poverty, but the narratives also emphasise learning the Arabic language, seen to facilitate male overseas migration to the Gulf countries, a channel for upward social and economic mobility. In a context of global competition that supports individualism, a focus on character and morality as represented through an Islamic identity, alongside communitarian values, is seen as important for maintaining a degree of social cohesion and is hence socially valued. Reading and reciting the Quran are also viewed as essential traits for a woman, enabling her to appropriately socialise her children in the absence of her migrant husband. One finds here a simultaneous process of contestation and resistance, seeking successful occupational trajectories and social recognition for men, while at the same time contributing to the reproduction of gendered inequalities.     

“王冕死了父亲”句的历史考察

语言在传承中不断变化,同样的意义,由于表达者的立足点和表达方式的差异,会出现不同的方式,形成同义关系,同义关系的语言成分之间互相影响,可能导致各种变化发生。同时,语言系统内部的联系是多向的,同义关系不仅存在于句子层面,还存在于句中用词和其他方面。本文认为王冕死了父亲一句正是以上因素的综合,在语言发展过程中逐渐形成的。     

Where are all the typical numbers — 2

In this two-part article, we are trying to discover patterns in the decimal digits of numbers between zero and one. In Part I we started showing that each digit occurs with frequency 1/10. We reduced the problem with the help of Borel-Cantelli Lemma and Markov inequality to show certain sums of integrals are finite. In this concluding part we bring in an essentially new ingredient and conclude the proof.     

瑶族学生英语写作中的“夹瑶”与“正言”

瑶族学生,特别是偏远山区的瑶族学生英语写作中＂夹瑶＂现象很严重,英语教师应通过从瑶语词汇及语言表述来揭示瑶语与英语的不同,对瑶族学生英语表述中＂夹瑶＂的现象给予正言。     

馆校结合科学教育活动项目要素分析——以“第四届科普场馆科学教育项目展评”为例

本文依托科学教育项目展评案例集,从课标对接、展品利用度、使用的技术、学习方式、活动的教育评估五个维度对科普教育活动实施过程进行调查和研究,并结合团队实地走访的科技博物馆访谈数据进行分析总结和探讨,旨在为科技博物馆教育活动的设计开发实施评估提供一些借鉴。