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141.
The present study was carried out to investigate the protective role of Triphala (a combination in equal proportions by weight
of fruit powder of Terminalia belerica, Terminalia chebula and Emblica officinalis) against 1,2-dimethylhydrazinedihydrochloride (DMH) induced Endoplasmic reticulum stress (ER stress) in mouse liver. An oral
dose of 3 mg/kg body wt in drinking water for 5 weeks significantly (P < 0.001) increased the levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase
(SGPT), serum Alkaline phosphatase (ALP) and total bilirubin thus suggesting damage to mouse liver and biliary dysfunction.
The DMH administration invariably led to increase in the liver microsomal proteins of molecular weight of about 29 (ERp29)
and 53 kDa (ERp53) and decrease in the protein of molecular weight of 36 kDa (ERp36) thereby suggesting the interference of
DMH and its metabolites with normal protein biosynthesis and folding, in the reticular membranes of the liver cells thus developing
ER stress. Histological studies show necrosis, large sized hepatocytes with increased N:C ratio, aberrant mitotic figures
and prominent nucleoli in the liver of DMH treated mice. In animals fed 5% Triphala in diet (w/w) during DMH administration,
there was significant decrease in the above changes in the liver suggesting the suppression of DMH induced ER stress in liver.
Triphala significantly (P < 0.05) decreased lipid peroxidation and also the activity of lactate dehydrogenase (LDH) in mouse liver. It simultaneously
increased the level of reduced glutathione (GSH) and the activity of glutathione-S-transferase (GST) thereby suggesting that
it prevents peroxidative damage and also diverts the active metabolites (electrophiles) of DMH from their interactions with
critical cellular bio-molecules which could be responsible for its protective action against DMH. 相似文献
142.
Cecile Paris Nathalie Colineau Surya Nepal Sanat Kumar Bista Gina Beschorner 《Ethics and Information Technology》2013,15(4):301-316
With the emergence and rapid growth of Social Media, a number of government departments in several countries have embraced Social Media as a privilege channel to interact with their constituency. We are exploring, in collaboration with the Australian Department of Human Services, the possibility to exploit the potential of social networks to support specific groups of citizens. To this end, we have developed Next Step, an online community to help people currently receiving welfare payments find a job and become financially self-sufficient. In this paper, we explore some ethical issues that arise when governments engage directly with citizens, in particular with communities in difficult situations, and when researchers are involved. We describe some of the challenges we faced and how we addressed them. Our work highlights the complexity of the problem, when an online community involves a government department and a welfare recipient group with a dependency relationship with that department. It becomes a balancing act, with the need to ensure privacy of the community members whilst still fulfilling the government’s legal responsibilities. While difficult, these issues must be addressed if governments are to engage with their citizens using Social Media. 相似文献
143.
Rhema Elizabeth Thomas Ajaikumar Sukumaran Arun Krishnan R Thushara Thomas Biby T Edwin P R Haritha Bilha M Varghese Jofy K Paul Satheesh Kumar C S D M Vasudevan 《Indian journal of clinical biochemistry : IJCB》2023,38(1):51
The vaccination efficacy can indirectly be assessed through the quantification of neutralizing antibodies. Very few data are available on Covishield efficacy in terms of neutralizing antibody expression upon vaccination. This study is focused on profiling of neutralizing antibody expression during and after the Covishield two shot vaccination and observing COVID-19 infection in vaccinated participants during the period. SARS CoV-2 neutralizing antibody concentrations in samples were estimated using electrochemiluminescence immunoassay kit for Lifotronics eCL8000. The sampling had been done sequentially at 45th, 85th day after 1st dose and 15th day after 2nd dose Covishield vaccination. Parallelly, in order to confirm the total SARS CoV-2 IgG response in COVID-19 infection, measured the IgG using SARS CoV-2 IgG lateral flow immunoassay test kit. The subjects previously infected with COVID-19 before 1st dose vaccination demonstrated high neutralizing antibody (> 10AU/ml). In COVID-19 uninfected subjects, there was a sudden incline in neutralizing antibody after the 2nd dose. Infection with SARS CoV-2 between 1st and 2nd dose of Covishield vaccination implicate that the level of neutralizing antibody in serum after 1st dose was not adequate to combat the virus and prevent infection. We observed COVID-19 infection in participants even after 2nd dose of vaccination. Interestingly, there was no protection against SARS CoV-2 even with a high neutralizing antibody expression of 188.5 AU/mL after the 2nd dose. Findings of Covishield efficacy in different cohort samples before and after 2 doses of Covishield vaccination provide impetus for improvement or development of next generation vaccines. 相似文献
144.
Sanjib Kumar Ghosh 《Anatomical sciences education》2017,10(3):286-299
Anatomical education has been undergoing reforms in line with the demands of medical profession. The aim of the present study is to assess the impact of a traditional method like cadaveric dissection in teaching/learning anatomy at present times when medical schools are inclining towards student‐centered, integrated, clinical application models. The article undertakes a review of literature and analyzes the observations made therein reflecting on the relevance of cadaveric dissection in anatomical education of 21st century. Despite the advent of modern technology and evolved teaching methods, dissection continues to remain a cornerstone of anatomy curriculum. Medical professionals of all levels believe that dissection enables learning anatomy with relevant clinical correlates. Moreover dissection helps to build discipline independent skills which are essential requirements of modern health care setup. It has been supplemented by other teaching/learning methods due to limited availability of cadavers in some countries. However, in the developing world due to good access to cadavers, dissection based teaching is central to anatomy education till date. Its utility is also reflected in the perception of students who are of the opinion that dissection provides them with a foundation critical to development of clinical skills. Researchers have even suggested that time has come to reinstate dissection as the core method of teaching gross anatomy to ensure safe medical practice. Nevertheless, as dissection alone cannot provide uniform learning experience hence needs to be complemented with other innovative learning methods in the future education model of anatomy. Anat Sci Educ 10: 286–299. © 2016 American Association of Anatomists. 相似文献
145.
Alistair McCulloch Vijay Kumar Susan van Schalkwyk Gina Wisker 《Quality in Higher Education》2016,22(1):64-77
Supervision is generally recognised as playing a crucial role in the quality of a research student’s doctoral experience and their academic outcomes and, in common with most areas of higher education, there is an oft-stated desire to pursue excellence in this important area. Excellence in research degree supervision is, however, an elusive concept and on close scrutiny most of the discussions of high-quality supervision, even those that purport to be identifying excellence, refer to competence rather than excellence. This paper examines two potentially national authoritative perspectives from which excellence in research degree supervision might be explicated (codes of practice and learning and teaching awards) from Australia, New Zealand, South Africa and the United Kingdom but concludes that the complex nature of the activity and the complexity of the concept itself mean that rather than identifying excellence in supervision we can only respond to claims for excellence. 相似文献
146.
Wei-Kai?Liou Kaushal?Kumar?Bhagat Chun-Yen?ChangEmail authorView authors OrcID profile 《Educational technology research and development : ETR & D》2018,66(2):545-561
The aim of this study is to design and implement a digital interactive globe system (DIGS), by integrating low-cost equipment to make DIGS cost-effective. DIGS includes a data processing unit, a wireless control unit, an image-capturing unit, a laser emission unit, and a three-dimensional hemispheric body-imaging screen. A quasi-experimental study was conducted to evaluate the learning effectiveness of our system. A total of 105 junior high-school students from Taiwan participated in this 8-week experiment. The students were divided into three individual groups of 35 students each, with one control group and two experimental groups (EG1 and EG2). The results of one-way mixed design ANOVA indicated that participants in the experimental group, who used the DIGS, outperformed the other two groups, in the post-test as well as in the delayed test. These findings demonstrate that the proposed DIGS can effectively enhance the performance of the learners in an Earth Science course. 相似文献
147.
KHATTRI Sanjay Kumar 《浙江大学学报(A卷英文版)》2006,7(12):2018-2021
INTRODUCTION Adaptive grids are desired for solving partial differential equations (PDEs) (Khattri, 2006a; 2007). There are various techniques for generating adaptive quadrilateral meshes. For example, solution of cou- pled elliptic system (Khattri, 2006d; Thompson et al., 1998), minimization of a functional or variational approach (Cao et al., 1999; 2003; Huang, 2001), etc. In this article, we present a simple and effective technique for generating adaptive quadrilateral meshes. Sever… 相似文献
148.
The Evolution of Global Positioning System (GPS) Technology 总被引:1,自引:0,他引:1
Early in the race to space in the 1950s, the U.S. Department of Defense found that tracking the position of satellites could be used to track fixed bodies on the surface of the Earth. No one realized that the NAVSTAR GPS satellite constellation program, that began its research and development in 1973 and launching its first four satellites in 1978, would change the very nature of our world in the next two decades. The system later to be known simply as the Global Positioning System (GPS) would not only provide complex navigation and timing capability to the military but, might very well, be the backbone to energize the faltering economy in 2001. A myriad of evolving GPS applications and complementary technologies may spawn new, much needed economic growth. Advances in integrated circuit technology and high-volume applications have helped to bring the price of GPS receivers down to $100–$500. The size of GPS receivers has now been considerably reduced. Prices and device sizes will continue to fall in the next decade while the applications for this technology will continue to blossom. It should be no surprise when this technology affects each of us, and, is used in every home and business in some form during this decade. 相似文献
149.
S. Sabesan G. Rajendran N. Pradeep Kumar 《Indian journal of clinical biochemistry : IJCB》1997,12(1):36-38
Three species of Mansonioides vectors viz.,Ma. annulifera, Ma. uniformis andMa. indiana were found in Cherthala taluk, Kerala which is one of the endemic areas due toB. malayi. The immatures of Mansonioides thrive mainly in association with macrophytic hydrophytes such asP. stratiotes, S. molesta andE. crassipes in perennial habitats (ponds, channels/ canals etc.,) andI. miliaceae in seasonal habitats (fallow lands etc.) Breeding potential was higher (130.19) in clean ponds withP. stratiotes, compared to that of polluted ones (40.69). However, the polluted habitats infested with the same host plants were found to be the most productive forMa. annulifera, with an average daily adult emergence rate of 601/100 sq.m.). The clean habitats played a major role in the contribution ofMa. uniformis, whereS. molesta in the perennial habitats and I. miliaceae in the seasonal fallow lands were the favourable plants contributing a daily output of 12.5/100 sq.m and 221.81/100 sq.m. respectively.E. crassipes infested polluted habitats formed the major source forMa. indiana, the emergence rate being 13.89/100 sq.m. The perennial habitats supported mainly the breeding ofMa. annulifera (70.82%), whereas the seasonal habitats contributed the major chunk ofMa. uniformis (92.54%) andMa. indiana (71.43%). The bionomics of Mansonioides mosquitoes are thus shown to be greatly influenced by the community structure of hydrophytes and also the nature of breeding habitats. 相似文献
150.
N. Pattanaik Ajita V Singh R. S. Pandey B. S. Singh Mohan Kumar S. K. Dixit Yamini B. Tripathi 《Indian journal of clinical biochemistry : IJCB》2003,18(2):181-189
Free radicals are implicated in various chronic diseases. There has always been a search for new antioxidants. In this paper
we have investigated Tamra bhasma, a metallic ayurvedic preparation. It is a time-tested medicine in Ayurveda and is in clinical
use for various ailments specifically the free radical mediated diseases. Our results show that Tamra bhasma inhibits lipid
peroxidation (LPO), prevents the rate of aerial oxidation of reduced glutathione (GSH) content and induces the activity of
superoxide dismutase (SOD) in rat liver homogenate in the bi-phasic manner. The drug was orally given for 7, 15 and 30 days
in different doses. Best protective response was found at the dose of 0.5mg/100g body weight in albino rats, although it showed
some histopathological changes at the dose of 20mg/100g body weight. The results suggest that this Ayurvedic preparation is
not merely a source of copper metal, but it is a strong anti-oxidant with no detectable adverse effect in lower doses of therapeutic
range. 相似文献