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41.
Rama Devi Mittal Amita Pandey Balraj Mittal Kailash Nath Agarwal 《Indian journal of clinical biochemistry : IJCB》2003,18(1):111-116
Eight weeks of latent iron deficiency in weaned female rats of Sprague Dawley strain maintained on experimental low-iron diet
(18–20 mg/kg) did not significantly change the gross body, weight and tissue weights of brain and liver. Packed cell volume
(PCV) and hemoglobin concentration remained unaltered. However, non-heme iron content in liver and brain decreased significantly
(p<0.001). The activities of glutamate dehydrogenase, glutamic acid decarboxylase, and GABA-transaminase (GABA-T) in brain
decreased by 15%, 11.4% and 25.7% respectively. However, this decrease was not statistically significant. Binding of3H Muscimol at pH 7.5 and 1 mg protein/assay increased by 143% (p<0.001) in synaptic vesicular membranes from iron-deficient
rats as compared to the controls.3H glutamate binding to the synaptic vesicles was also carried out under similar condition. However, the L-glutamate binding
was reduced by 63% in the vesicular membranes of iron deficient animals. These studies indicate that iron plays important
functional role in both excitatory and inhibitory neurotransmitter receptors. 相似文献
42.
Chhillar N Khurana S Agarwal R Singh NK 《Indian journal of clinical biochemistry : IJCB》2011,26(1):46-49
Advances in instrument technology and automation have simplified tasks in laboratory diagnostics reducing errors during analysis
thereby improving the quality of test results. However studies show that most laboratory errors occur in the pre-analytical
phase. In view of the paucity of studies examining pre-analytical errors, we examined a total of 1513 request forms received
at our laboratory during a 3 month period. The forms were scrutinized for the presence of specific parameters to assess the
pre-analytical errors affecting the laboratory results. No diagnosis was provided on 61.20% of forms. Type of specimen was
not mentioned in 61.60% of the forms and 89.25% of all forms were illegible. Critical results were encountered in 17.30% of
patients, and of these 76.60% were not communicated due to incomplete forms. Thus, by following standard operating procedures
vigorously from patient preparation to sample processing the laboratory results can be significantly improved without any
extra cost. 相似文献
43.
Srivastava N Prakash J Lakhan R Agarwal CG Pant DC Mittal B 《Indian journal of clinical biochemistry : IJCB》2011,26(2):125-130
Glucocorticoids and its receptor are known to be involved in the dysregulation of hormone and lipid levels. Therefore, we
evaluated the association of Bcl1 gene polymorphism of glucocorticoids receptor (GCR) gene variant with hormone and lipid levels in Northern Indians obese. A total of 435 obese and non-obese age matched subjects
were included in the case–control study. Lipid and hormonal levels were estimated using standard protocols. Analysis of +646
C>G NR3C1 gene polymorphism was done using PCR–RFLP. The frequencies of GR Bcl1, C>G genotypes and alleles did not differ significantly (P > 0.05) between obese and non-obese. The +646 G allele carriers had higher waist to hip ratio, blood pressure, insulin and
glucose levels than non-carriers in obese subjects while diastolic blood pressure and glucose in non-obese. The NR3C1, +646 C>G polymorphism did not associate with obesity. However, the GG genotype may modulate blood pressure, blood glucose
and hormonal levels in northern Indians. 相似文献
44.
Sanaz Farhangi 《Cultural Studies of Science Education》2012,7(4):1037-1044
This paper presents a review of Jane McGonigal’s book, “Reality is broken” (Reality is broken: why games make us better and how they can change the world. Penguin Press, New York, 2011). As the book subtitle suggests it is a book about “why games make us better and how they can change the world”, written by a specialist in computer game design. I will try to show the relevance this book might have to science educators through emphasizing the points that the author offers as the fixes to rebuild reality on the image of gaming world. Using cultural-historical activity theory, I will explore how taking up a gamer mindset can challenge one to consider shortcomings in current approaches to the activity of teaching–learning science and how using this mindset can open our minds to think of new ways of engaging in the activity of doing science. I hope this review will encourage educators to explore the worldview presented in the book and use it to transform our thinking about science education. 相似文献
45.
Subhash C. Arya Nirmala Agarwal Beena Michael 《Indian journal of clinical biochemistry : IJCB》2014,29(4):510-513
Analytical functioning of a point-of-care analyzer, i-Smart 30 (i-sens: Seoul, South Korea), for electrolyte quantification was investigated at Sant Parmanand Hospital, a tertiary-care hospital in Delhi, India. Samples that were received for electrolyte assay were assayed, double-blinded for their Na and K level using the arterial blood gas analyzer, the ABL 555 (Radiometer, Copenhagen) and the i-Smart 30 electrolyte analyzer. There was satisfactory correlation between the results obtained with the two analyzers with an encouraging bias, standard deviation and the 95 % limits of agreement between the data generated for Na and K levels. The performance of the i-Smart 30 would be satisfactory during the point-of-care measurements of Na and K levels in emergency rooms and clinical laboratories with inadequate infrastructure only if its day-to-day performance was monitored to ensure reliability of the generated reports. 相似文献
46.
47.
Afzal Ahmad Benedicta D’Souza Charu Yadav Ashish Agarwal Anand Kumar M. Nandini Vivian D’Souza A. M. Poornima Nutan Kamath 《Indian journal of clinical biochemistry : IJCB》2016,31(4):480-482
Alstrom’s syndrome (AS) is a rare autosomal recessive ciliopathic condition affecting 1:10,00,000 children. It’s a single gene disorder of ALMS1 on chromosome 2 with multisystem involvement with cone-rod retinal dystrophy causing juvenile blindness, obesity, insulin resistance, type 2 Diabetes mellitus, hypogonadism and sensorineural hearing loss. Till now only 800 patients with this disorder has been identified so far. In this report, we describe the case of a 9-year old male boy from south India. He had been initially referred for polyphagia, polyuria, polydipsia, generalized weakness from 1 weeks. On examination he was demonstrated features suggestive of AS, including blindness, obesity, type 2 diabetes, altered lipid profile, hypogonadism, acanthosis nigricans, seborrheic dermatitis, right ear discharge and episodes of respiratory tract infections. So, diagnosis of AS is critical as it can easily be overlooked because of the many features associated with metabolic syndrome starting at age 7, a relatively early age. 相似文献
48.
49.
S. Chhabra D. P. Agarwal S. Vasisht K. Luthra R. Narang S. C. Manchanda L. M. Srivastava N. Das 《Indian journal of clinical biochemistry : IJCB》2003,18(2):34-38
Several studies including a small case-control (hypertriglyceridemic/normotriglyceridemic individuals) study by us revealed
close association between rare S2 allele ofAPOC3 Sstl polymorphism and hypertriglyceridemia. With the understanding that Asian Indians are highly vulnerable to the adverse
effects of hypertriglyceridemia, we extended the investigation and studied the frequency distribution of this polymorphism
in 216 healthy volunteers from Northern plains of India. We found that more than 50% of the study population had one or two
S2 allele. This may suggest that a larger fraction of this population is genetically predisposed to hypertriglyceridemia. 相似文献
50.
Rama Devi Mittal Amita Pandey Balraj Mittal Kailash Nath Agarwal 《Indian journal of clinical biochemistry : IJCB》2002,17(2):1-6
Eight weeks of latent iron deficiency in weaned female rats of Sprague Dawley strain maintained on experimental low-iron diet
(18–20 mg/Kg) did not significantly change the gross body weight and tissue weights of brain and liver. Packed cell volume
(PCV) and hemoglobin concentration remained unaltered. However, non-heme iron content in liver and brain decreased significantly
(P<0.001). The activities of glutamate dehydrogenase, glutamic acid decarboxylase, and GABA-transaminase (GABA-T) in brain
decreased by 15%, 11.4% and 25.7% respectively. However, this decrease was not statistically significant. Binding of3H Muscimol at pH 7.5 and 1 mg protein/assay increased by 143% (P<0.001) in synaptic vesicular membranes from iron-deficient
rats as compared to the controls.3H glutamate binding to the synaptic vesicles was also carried out under similar condition. However, the L-glutamate binding
was reduced by 63% in the vesicular membranes of iron deficient animals. These studies in dicate that iron plays an important
functional role in both excitatory and inhibitory neurotransmitter receptors. 相似文献