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151.
S. Chhabra D. P. Agarwal S. Vasisht K. Luthra R. Narang S. C. Manchanda L. M. Srivastava N. Das 《Indian journal of clinical biochemistry : IJCB》2003,18(2):34-38
Several studies including a small case-control (hypertriglyceridemic/normotriglyceridemic individuals) study by us revealed
close association between rare S2 allele ofAPOC3 Sstl polymorphism and hypertriglyceridemia. With the understanding that Asian Indians are highly vulnerable to the adverse
effects of hypertriglyceridemia, we extended the investigation and studied the frequency distribution of this polymorphism
in 216 healthy volunteers from Northern plains of India. We found that more than 50% of the study population had one or two
S2 allele. This may suggest that a larger fraction of this population is genetically predisposed to hypertriglyceridemia. 相似文献
152.
Rachita Nanda Pramila K. Mishra U. K. Das S. B. Rout P. C. Mohapatra A. Panda 《Indian journal of clinical biochemistry : IJCB》2004,19(1):93-96
Serum malondialdehyde was measured in sixty-one falciparum malaria cases, which include thirty uncomplicated, and thirty-one
complicated with acute renal failure. Twenty-six healthy individuals were also studied as controls. Serum malondialdehyde
level was found to be significantly elevated in falciparum malaria induced acute renal failure cases when compared with uncomplicated
falciparum malaria (p<0.001) and healthy controls (p<0.001). A positive correlation with the raised urea, creatinine and bilirubin
levels were significant (r=0.62, p<0.025; r=0.65, p<0.05 and r=0.72, p<0.001 respectively) indicating the severity of complication
with rise of lipid peroxides in falciparum malaria induced acute renal failure cases. 相似文献
153.
Saroj Kant Sinha Satya Vati Rana Deepak Kumar Bhasin Kusum Joshi 《Indian journal of clinical biochemistry : IJCB》2005,20(1):169-172
Duodenal ulcer is a common disease and is considered acid-peptic disease. Duodenal ulcer patients are known to have higher
incidence of antral gastritis and duodentitis than general population. Thus one can expect some alteration in the enzyme products
of mucosal cells of antrum and duodenum in this condition. The present study was planned in 30 patients of duodenal ulcer
and 30 of non-ulcer dyspepsia. After overnight fast, upper gastrointestinal endoscopy was done using forward viewing fibreoptic
endoscope. Two pairs of biopsies were taken from the antrum and two from the descending duodenum using standard biopsy forceps.
One pair of biopsy from each site was taken in 10% formal saline for histopathological examination. One pair of biopsies from
each site was collected in saline for the measurement of disaccharidases by Dahlquist method. Activities of lactase, sucrase
and maltase were significantly higher in descending duodenum mucosa as compared to antral mucosa in both groups. Activities
of these enzymes in antrum and duodenum of both groups did not differ significantly. No significant difference was found in
disaccharidases in antrum and descending duodenum in patients with or without histological gastritis. This study suggests
that the disaccharidases do not change in antrum and duodenum of ulcer patients as compared to the patients with non-ulcer
dyspepsia. 相似文献
154.
155.
Ethanol-induced liver injury may be linked, at least partly, to an oxidative stress resulting from increased free radical
production and/or decreased antioxidant defence. Distinguishing alcoholic and non-alcoholic liver disease has important implications.
This study looked at the possible changes between alcoholic and non-alcoholic liver diseases by examining the presence of
oxidative damage, as monitored by several parameters relating to oxidative stress. Lipid peroxides concentration, superoxide
dismutase activity and glutathione S-transferase activity increased, where as glutathione content, glutathione peroxidase
activity and glutathione reductase activity decreased among the tested subjects in comparison to normal healthy group. Determination
of these parameters may be valuable in the evaluation of liver disease. However, oxidative stress related enzymes and non-enzymes
can not be utilized as a marker for alcoholic liver diseases, as these parameters responded in the same way after liver is
damaged irrespective of their cause. Their level may help in determining the degree of liver damage. Degree of oxidative injury
was similar in patients with non-alcoholic liver disease and in moderate drinkers; while significantly higher in heavy drinkers.
The differences between the groups might be based on the type of liver pathological condition rather than its etiology (i.e.
alcohol and non alcohol related causes). 相似文献
156.
M. Banerjee S. Bhattacharyya C. Das 《Indian journal of clinical biochemistry : IJCB》1999,14(1):19-25
A simple, highly sensitive, direct, competitive ELISA for human serum testosterone has been indigenously developed. Specific
antisera against testosterone were raised in rabbits using testosterone—3carboxymethyl oxime (CMO)—bovine serum albumin (BSA)
as the antigen. For the enzyme conjugate, testoterone—3CMO was coupled with horse raddish peroxidase by the active ester method.
The standard curve covered a wide range from 3.9 pg/ml to 500 pg/ml. The inter and intra-assay variation were found to be
low and within the acceptable limits. Specificity and accuracy for the assay was established by having negligible crossreactivity
with the related steroids and an excellent parallelism between the sample and standard dilution curve. Samples measured by
RIA and ELISA showed very high degree of correlation (r=0.991). 相似文献
157.
B. Sivasankar K. R. Raju V. Anand S. Malu S. Padmanabhan S. C. Tiwari Nibhriti Das L. M. Srivastava 《Indian journal of clinical biochemistry : IJCB》1999,14(2):237-240
A decrease in the membrane anchored erythrocyte complement receptor 1 (CR1) is reported as an acquired phenomenon in a number
of inflammatory and autoimmune diseases with concomitant rise in soluble CR1 (sCR1) levels in plasma. There is a need to establish
the normal range of sCR1 in Indian adults to assess the function and disease association of this protein. The plasma sCR1
levels of 50 healthy individuals have been estimated by an indigenously developed sandwich ELISA. sCR1 levels from 26 patients
suffering from nephropathies had also been assayed which was much higher than the normal controls. This observation suggests
sCR1 as a potential market for the assessment of disease activity in nephropathies. 相似文献
158.
Alcohol induced effects on kidney 总被引:1,自引:1,他引:0
After administration ethanol and its metabolites go through kidneys and are excreted into urine, and its content in the urine
is higher than that of the blood and the liver. Chronic ethanol administration decreases the renal tubular reabsorption and
reduces renal function. Multiple functional abnormalities of renal tubules may be associated with ethanol-induced changes
in membrane composition and lipid peroxidation. The vulnerability of the kidney to oxidative damage has been partly attributed
to its high content of long-chain polyunsaturated fatty acids. Renal ultra structural abnormalities due to ethanol exposure
may be important in the genesis of functional disturbances. Increased oxidative stress and endothelial dysfunction with their
complex interrelationships are relevant aspects of atherogenesis in chronic renal failure. Antioxidants, particularly polyphenols
are expected to decrease the vulnerability of the kidney to oxidative challenges. 相似文献
159.
160.
Purba Das 《Journal of Intercultural Communication Research》2014,43(3):264-282
This paper investigates how the official discourse of race and caste are constructed in response to the Dalits’ claims that casteism is racism and caste should be included in the World Conference against Racism, Racial Discrimination, and Xenophobia (WCAR held in Durban in 2001). The research question driving this project probes into discursive strategies and logics, which deny any association of caste with race in the Indian context and the significance of race denial. The paper also questions whether the denial of association of race and caste is indicative of racial Indianization. I argue that in India, race lives through the category of caste as a form of racial Indianization. 相似文献