IGF1–PI3K-induced physiological cardiac hypertrophy: Implications for new heart failure therapies,biomarkers, and predicting cardiotoxicity

Heart failure represents the end point of a variety of cardiovascular diseases. It is a growing health burden and a leading cause of death worldwide. To date, limited treatment options exist for the treatment of heart failure, but exercise has been well-established as one of the few safe and effective interventions, leading to improved outcomes in patients. However, a lack of patient adherence remains a significant barrier in the implementation of exercise-based therapy for the treatment of heart failure. The insulin-like growth factor 1 (IGF1)–phosphoinositide 3-kinase (PI3K) pathway has been recognized as perhaps the most critical pathway for mediating exercised-induced heart growth and protection. Here, we discuss how modulating activity of the IGF1–PI3K pathway may be a valuable approach for the development of therapies that mimic the protective effects of exercise on the heart. We outline some of the promising approaches being investigated that utilize PI3K-based therapy for the treatment of heart failure. We discuss the implications for cardiac pathology and cardiotoxicity that arise in a setting of reduced PI3K activity. Finally, we discuss the use of animal models of cardiac health and disease, and genetic mice with increased or decreased cardiac PI3K activity for the discovery of novel drug targets and biomarkers of cardiovascular disease.     

Actors who can’t play in the sports film: exploring the cinematic construction of sports performance

The sports film often focuses upon character psychology and narrative in the cinematic capturing and construction of sport and sports performance. However, the limited attention given to the role of the actor’s body threatens to compromise this seamless dramatic structure of the narrative, not to mention viewer identification with the protagonist, thus leading to inadequate sporting technique that fails to achieve verisimilitude. This paper looks to address the limitations in the actor’s bodily performance, by rethinking the relationship between the actor’s physical portrayal and their cinematic construction. I argue that cinematic techniques should function as an extension of the actor’s body, thus creating a more seamless fusion between the two. Adopting such a method would facilitate a more heightened representation of sports performance, while contributing to the unfolding of the plot through the bodily interactions between the actors during the spectacle of sports sequences.     

A sudden creatinine increase: A case report

Creatinine and estimated glomerular filtration rate (eGFR) are first-line laboratory parameters in the diagnosis of various renal diseases. In recent decades, cystatin C (cysC) has furthered the laboratory repertoire regarding renal status assessment and has been implemented in many clinical guidelines. Accordingly, with the establishment of cysC as a renal routine biomarker, further opportunities for assessing eGFR have been attained. Nevertheless, various limitations are still associated with cysC and creatinine analysis. Preanalytical errors could cause false results in both biomarkers. In our case, we were confronted with implausibly elevated creatinine levels due to preanalytical errors.     

Correlates of health in adolescent elite athletes and adolescents: A cross-sectional study of 1016 adolescents

The primary aim of this cross-sectional study was to compare subjective correlates of health, such as nutrition, self-esteem, sleep and stress, between adolescent elite athletes (n?=?625) and a reference group of adolescents (n?=?391) not involved in elite sports. A secondary aim was to study predictors for self-perceived stress. A questionnaire was e-mailed to all participants containing valid questions about competence-based self-esteem, nutrition, self-perceived stress and sleep. Our results show that adolescent elite athletes reported significantly (p?p?相似文献   

Automated vehicles and the morality of post-collision behavior

Ethics and Information Technology - We address the considerations of the European Commission Expert Group on the ethics of connected and automated vehicles regarding data provision in the event of...     

Sport activities differentiating match-play improvement in elite youth footballers – a 2-year longitudinal study

This study examined contributions of different types of sport activities to the development of elite youth soccer performance. Match-play performance of 44 German male players was assessed by expert coaches twice, 24 months apart (age 11.1–13.1 years), based on videotaped 5v5 matches. Player pairs were matched by identical age and initial performance at t₁. Each player was assigned to a group of either “Strong” or “Weak Responders” based on a higher or lower subsequent performance improvement at t₂ within each pair (mean Δperformance 29% vs. 7%). A questionnaire recorded current and earlier amounts of organised practice/training and non-organised sporting play, in soccer and other sports, respectively. Group comparison revealed that “Strong Responders” accumulated more non-organised soccer play and organised practice/training in other sports, but not more organised soccer practice/training. Subsequent multivariate analyses (multiple linear regression analyses (MLR)) highlighted that higher resultant match-play performance at t₂ was accounted for R²_adj = 0.65 by performance at t₁, together with more non-organised soccer play and organised engagement in other sports, respectively, and greater current, but less earlier volume of organised soccer. The findings suggest that variable early sporting experience facilitates subsequent soccer performance development in German elite youth footballers.