Some biochemical markers in various neoplasms: A multivariate analysis

The analysis of biochemical parameters in 162 patients with various neoplastic disorders along with 50 normal subjects showed significant rise in serum alkaline phosphatase and lactate dehydrogenase as compared to normal subjects. 21 patients with other monoclonal gammopathies which include infection and immunological diseases were also studied. Parameters such as serum calcium, uric acid, total protein, albumin and globulin were also analyzed in 42 (26%) cases of multiple myeloma, 27 (17%) cases of gastro-intestinal malignancies, 22 (14%) cases of urogenital malignancies, 11 (6%) cases of carcinoma breast, 4 (2%) cases of bone tumors, 21 (12%) cases of other monoclonal gammopathies, including 7 (4%) cases of infection and 14 (8%) cases of immunological diseases. The results indicate use of enzymes alkaline phosphatase and lactate dehydrogenase in neoplastic disorders.     

Breast cancer in developing population: A nutrition caveat

From January 1992-January 1998, 1404 patients attended the “Breast Clinic” of R.N.T. Medical College M.B. Hospital, Udaipur. Out of these, 11% and 81% patients had breast cancer (B.C.) and benign breast cancer (B.B.D.) respectively. The oxidative load in B.C. was 2.32 times higher than controls, but comparable to B.B.D. β-Carotene deficiency was uncommon in patients, whereas vitamin A deficiency was almost equally common in both B.C. and controls. Most of the patients had almost depleted levels of α-tocopherol and ascorbic acid but their TBAR levels were in normal range. The data in the present study when compared with B.B.D. and other local normal subjects point out: a) oxidative burden in B.C. is a consequence and not the cause of the disease, (b) oxidative stress could be one of the etiological factors in tumor expression, which need not to be malignant and c) α-tocopherol and ascorbic acid are not importantly responsible for higher oxidative burden in B.C.     

Sexuality education in India: examining the rhetoric,rethinking the future

Comprehensive sexuality education (CSE) has been recognised globally as key to helping young people assert their sexual and reproductive rights. In India too, there is growing awareness of the importance of providing CSE not only to reduce sexually transmitted infections, unintended pregnancies and abortions but also to teach important life skills. Simultaneously, lack of political will and conflicting interests among certain religious and political factions have ensured that no uniform CSE curriculum has been implemented throughout the country. This paper analyses the Adolescent Education Programme teacher curriculum as revised in 2009–2010 by the National Council of Educational Research and Training and the United Nations Population Fund. It highlights some of the opportunities presented by the curriculum and argues that despite its intent of providing relevant sexuality education for young people, the language of the curriculum is vague, thus potentially exacerbating confusion, and excluding people who do not conform to societal stereotypes of sex, gender, and ability. In order to be holistic, any CSE programme must be inclusive, cater to diverse needs and present content in a rights-based language without adding to the socio-cultural context of mystery and shame attached to sexuality.     

Cognitive performance of dysphasic students

The cognitive abilities of a group of dysphasic children in a special school in Finland were examined in this study to answer the following questions: Can we categorize their cognitive processing as planning, arousal-attention, simultaneous and successive processing (PASS)? The second question was concerned with detecting subgroups within the dysphasic sample in terms of PASS processes. The subjects were 60 dysphasic children in a special school. Their ages ranged from 7 to 19 years. All subjects were administered tests of planning, arousal-attention as well as simultaneous and successive processing. They were also administered the Wechsler test of intelligence for children and adults according to their ages, two sub-scales of Wechsler memory scale, as well as three ad hoc tests, cancellation task, KS persons and Rey Osterrieth copy task. The results of the factor analysis generally confirmed the emergence of the four PASS factors. As a results of cluster analysis, two subtypes of dysphasics emerged categorized as clearly high and low in the successive factor as well as relatively high and low on the simultaneous factor scores. The low-simultaneous/low-successive group was significantly lower in WISC verbal IQ the Wechsler memory scale for logical memory, and the ad hoc test of KS persons. The results were discussed, in terms of the importance of understanding the language problems typically associated with the two subtypes as well as the remedial program which will take into account their cognitive differences in spite of the fact that both groups had significant language impairment.     

Young children's causal inferences

We report 2 experiments that show a striking development between the ages of 3 and 4 years in children's ability to make causal inferences about sequences of events. The task in the first experiment was to work out what had caused the change to an object that started out as odd (noncanonical) in 1 way and ended up as odd in 2 ways--starting, for example, as a broken cup and ending as a wet and broken cup. When asked to choose the instrument that had caused the change, 3-year-olds often selected the instrument that could have caused the initial state (a hammer, in our example) and not the instrument that would produce the change. 4-year-olds hardly ever made this mistake. In the second experiment, the 3-year-olds were able to make the correct choice when the change was from a canonical to a noncanonical state (cup-wet cup) but had much more difficulty when the change was from noncanonical to canonical (wet cup-dry cup). The difference was much smaller in the older group. The first of these tasks can be solved simply on the basis of knowledge that a particular instrument can cause a particular effect without reference to the initial state. The second task requires attention to the differences between initial and final state. We conclude that the ability to make genuine causal inferences develops between the ages of 3 and 4 years.     

The madelung constant of the sodium chloride crystal lattice

An analysis of the Madelung constant of the sodium chloride crystal lattice has been made, in an effort to supplement information available in undergraduate textbooks. A method of approximation of the constant using the personal computer is presented. An erratum to this article is available at .     

What is a Species? An endless debate

Everybody is familiar with the ubiquitous term ‘species’. But what is a species? Undeniably, this is one of the most complex dilemmas in the history of biology. There is no other concept in biology as elementary yet controversial as the concept of species. In practice, a species is regarded as the fundamental unit of comparison in all biological disciplines like systematics, evolution, ecology, ethology, physiology, and genetics. However, little agreement exists in the scientific community regarding the nature of species, whether it is a real entity or a cultural artifact, its biological significance or how to delineate a species. This article is a review of the seemingly endless debate on the species concept and its implications.