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41.
Some research within developmental psychology shows a slow period of development in children's expressive drawings during the primary school years. Developmental researchers suggest that ‘educational factors’ could contribute to this dip in development but have not explored these factors. This study explores links between educational policy – in terms of the English National Curriculum – and the development of expression in child art. A Foucauldian style analysis of interviews is presented which investigates how ten primary school teachers working in two Staffordshire schools approach art. A specific concern is to explore how different understandings of art and teaching practices are shaped and managed by the curriculum. This allows links between the demands of the curriculum and the observed dip in expressive drawing development to be investigated. 相似文献
42.
Subir Kumar Das L. Dhanya Sowmya Varadhan Sukhes Mukherjee D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2009,24(3):301-306
Alcohol consumption and health outcomes are complex and multidimensional. Ethanol (1.6g / kg body weight/ day) exposure initially
affects liver function followed by renal function of 16–18 week-old male albino rats of Wistar strain weighing 200–220 g.
Chronic ethanol ingestion increased in thiobarbituric acid reactive substances level and glutathione s-transferase activity;
while decreased reduced gluatathione content and activities of catalase, glutathione peroxidase and glutathione reductase
in a time dependent manner in the hemolysate. Though superoxide dismutase activity increased initially might be due to adaptive
response, but decreased later. Elevation of serum nitrite level and transforming growth factor-b1 activity indicated that long-term ethanol consumption may cause hepatic fibrosis and can elicit pro-angiogenic factors. However,
no alteration in vascular endothelial growth factor-C activity indicated that ethanol consumption is not associated with lymphangiogenesis.
Therefore, we conclude that long-term ethanol-induced toxicity is linked to an oxidative stress, which may aggravate to fibrosis
and elevate pro-angiogenic factors, but not associated with lymphangiogenesis. 相似文献
43.
Subir Kumar Das Sukhes Mukherjee Gaurav Pandey V. Balakrishnan D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2009,24(2):155-158
Non-alcoholic fatty liver disease and its more aggressive form, non-alcoholic steatohepatitis are entities that are becoming
more and more interesting to the medical community in general. A total of 93 Non-alcoholic fatty liver disease patients (64
male and 29 female) within the age range between 28 to 63 years were studied. All of them showed elevated alanine aminotransferase
level (104.07 ± 56.04). Aspartate aminotransferase level (58.13 ± 31.96) was elevated more than its normal level in 82% cases
and AST to ALT ratio was found 0.59 ± 0.26. Predisposing factors were diabetes mellitus (37%), obesity (13%) and hyperlipidemia
(41%). In addition, 32% of the subjects were overweight.18% of the patients had elevated serum bilirubin. Our findings recommend
a lower cutoff value than suggested by the World Health Organization for overweight and obesity among this racial-ethnic group. 相似文献
44.
Benedicta D’Souza Vivian D’Souza S. Sowmya G. Seema C. N. Hemalatha M. Anu G. Sajana 《Indian journal of clinical biochemistry : IJCB》2008,23(3):218-222
The study was conducted to find out the extent of lipid peroxidation and antioxidant status in ischemic stroke patients (ISPs)
with and without diabetes. Malondialdehyde (MDA) was studied as a marker of lipid peroxidation. Glutathione (GSH), uric acid
and ceruloplasmin were estimated to study the antioxidant potential of ISPs. Significantly higher levels of MDA were found
in both the groups of ISPs and the increase in MDA was more in ISPs without diabetes. GSH levels were decreased significantly
in both the groups of ISPs and maximum decline was found in ISPs with diabetes. Uric acid levels were significantly increased
in both the groups of ISPs. Ceruloplasmin levels were increased significantly in ISPs without diabetes, whereas its levels
were slightly decreased in ISPs with diabetes. A negative correlation was found between MDA and the antioxidants GSH, uric
acid and ceruloplasmin in ISPs with diabetes. This study suggests that there is an association between ischemic stroke and
increased oxidative stress and the antioxidant potential is impaired in both the groups of ISPs with and without diabetes. 相似文献
45.
Suman B. Sharma Seema Garg Abhinav Veerwal Sridhar Dwivedi 《Indian journal of clinical biochemistry : IJCB》2008,23(4):334-336
Premature coronary artery disease (CAD) is common in India. We, therefore, studied oxidative stress, dyslipidemia, and high
sensitivity-C reactive protein (hs-CRP) levels in young CAD patients. Present study consisted of male CAD patients below 40
years and age and sex matched healthy controls (n=30 each). Fasting blood samples were analyzed for serum lipid profile, malondialdehyde,
antioxidant enzymes and hs-CRP levels. Dyslipidemia was observed in 90% of the young CAD patients, of which 72.2% showed increased
serum triglycerides and decreased HDL-cholesterol. LDL-cholesterol levels were high in 77.8%. Serum malondialdehyde and hs-CRP
levels were increased significantly (p<0.0001) as compared to controls. hs-CRP levels were in high risk range in all the young
patients. However, glutathione peroxidase activity was reduced significantly (p<0.05). Our data suggests that elevated hs-CRP
levels along with dyslipidemia and oxidative stress adds to the predictive value of premature CAD in young Indians. 相似文献
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49.
Forty-five Grade 3 students from a reservation school in Western Canada were divided into two remedial groups and a no-risk control group. One remedial group was given a classroom-administered cognitive enhancement program (COGENT) throughout the school year. The second group received COGENT for the first half of the year followed by a pull-out cognitive-based reading enhancement program (PREP). Children were assessed across phonological awareness, rapid naming, reading, and cognitive ability at the beginning of the year, mid-term, and at the end of the school year. MANOVA results showed a significant interaction for reading measures, with students receiving classroom intervention over the school year making the greatest gains. Results are discussed in terms of group, remediation program, and individual participant improvements. 相似文献
50.
Lu XF He GQ Yu HN Ma Q Shen SR Das UN 《Journal of Zhejiang University. Science. B》2010,11(12):923-930
Polyunsaturated fatty acids (PUFAs) possess anti-cancer action both in vitro and in vivo. In the present study, we detected
cell viability with methyl thiazolyl tetrazolium (MTT) assay and cell membrane permeability with propidium iodide (PI) fluorescence
dyeing, and calculated cell membrane fluidity change as fluorescence anisotropy. Fatty acid content in cells was measured
by gas chromatography/mass spectroscopy (GC/MS), and the relationship between fatty acid composition and cell viability was
studied. We observed that n-6 PUFA linoleic acid (LA) inhibited tumor cell growth at high concentrations (≥300 μmol/L), while low concentrations (100–200
μmol/L) seemed to promote cell proliferation. Analyses of cell membrane permeability, cell membrane fluidity, and cell fatty
acid composition suggested that the anti-cancer action of LA could be related to changes in the ratio of n-6 to n-3 PUFAs. We observed that pre-incubation of cancer cells with 100 μmol/L LA for 24 h enhanced cell sensitivity to the cytotoxic
action of LA, whereas undifferentiated cell line LoVo seemed to have a distinct path in LA-induced death. These results showed
that one of the mechanisms by which supplementation of LA induces cancer cell death could be altering the ratio of n-6/n-3 PUFAs, and this may be related to cell differentiation status. 相似文献