汉代《诗经》解释学中的哲学机制管窥

汉代《诗经》解释学与阴阳气论哲学、感应哲学密不可分。以汉儒解释《旱麓》《灵台》二诗诗句时所言君王"德及鸟兽鱼鳖"为例,其意义与《吕氏春秋》中言商汤"德及禽兽"而"网开一面"不同,非指君王某一具体行为惠及鸟兽,而是指在天地人同具阴阳之气的基础上,君王之德与自然之气同类相感,在此意义上泽及鸟兽鱼鳖。     

论知识产权的反垄断规制

知识产权强国利用其知识产权的绝对优势占领我国市场,并以此形成垄断格局。本文在剖析了知识产权与反垄断法关系的基础上,对我国知识产权滥用进行反垄断规制的重要性和必要性有了进一步阐明,并对如何构建中国知识产权反垄断体系进行了探讨。     

反腐成本论

本文认为我国腐败滋生的一个主要原因就是由于腐败的制约成本、经济成本和心理成本太低造成的。通过加大监督机制的制约成本、提高破案率,加大处罚成本、从重处罚,增加经济成本和强化思想道德建设,美化养廉的“生态环境”,提高心理成本等措施来提升腐败成本,从而有效地制约腐败行为。     

An integrated microfluidic system for screening of phage-displayed peptides specific to colon cancer cells and colon cancer stem cells

Affinity reagents recognizing biomarkers specifically are essential components of clinical diagnostics and target therapeutics. However, conventional methods for screening of these reagents often have drawbacks such as large reagent consumption, the labor-intensive or time-consuming procedures, and the involvement of bulky or expensive equipment. Alternatively, microfluidic platforms could potentially automate the screening process within a shorter period of time and reduce reagent and sample consumption dramatically. It has been demonstrated recently that a subpopulation of tumor cells known as cancer stem cells possess high drug resistance and proliferation potential and are regarded as the main cause of metastasis. Therefore, a peptide that recognizes cancer stem cells and differentiates them from other cancer cells will be extremely useful in early diagnosis and target therapy. This study utilized M13 phage display technology to identify peptides that bind, respectively, to colon cancer cells and colon cancer stem cells using an integrated microfluidic system. In addition to positive selection, a negative selection process was integrated on the chip to achieve the selection of peptides of high affinity and specificity. We successfully screened three peptides specific to colon cancer cells and colon cancer stem cells, namely, HOLC-1, HOLC-2, and COLC-1, respectively, and their specificity was measured by the capture rate between target, control, and other cell lines. The capture rates are 43.40 ± 7.23%, 45.16 ± 7.12%, and 49.79 ± 5.34% for colon cancer cells and colon cancer stem cells, respectively, showing a higher specificity on target cells than on control and other cell lines. The developed technique may be promising for early diagnosis of cancer cells and target therapeutics.     

低压配电系统无功补偿柜的设计

无功功率补偿将降低供电系统的功率损耗和电能损耗,减少变压器和线路中的电压损失和提高供电设备利用率。试通过鸡西赫阳燃气有限公司低压配电系统无功补偿柜的设计过程来阐述低压配电系统无功补偿方式选择及无功补偿容量的确定。     

“双减”政策背景下青少年体育活动开展策略研究

为了在“双减”政策背景下进一步推进青少年体育活动的开展,通过文献资料法、综合分析法等研究方法,分析了目前青少年体育活动面临的一些问题,并提出如下对策:树立正确的体育价值观,强化体育意识的培养;扩大资源的有效供给,推动青少年体育活动的开展;发挥“家、校、社”主导作用,切实建设联动共同体;建立长效保障机制和治理监管体系,有效防范化解各类风险。     

知识考古与历史重诂:编撰《林纾年谱长编》的构想

论述编撰《林纾年谱长编》的总体构想。课题尝试运用现代史学方法对近代闽籍历史名人林纾进行知识考古和重诂,涉及谱主一生四个不同特质的时期。介绍这项课题的选题背景、动机和主要任务,同时提出年谱编撰方法方面的新观点。研究的目的是以新的历史观重构特定时期的历史人物。     

“数字中国”布局下我国城建档案馆数字化转型之思考

"数字中国"布局下,城建档案馆将为智慧城市规划与建设提供可靠的档案数据支持。城建档案馆行政执法过程中面临缺少上位法、缺少行政许可、与上级行政主管部门职能交叉等问题,亟待解决。在数字化城建档案馆建设的进程中,受"放管服"行政指引,城建档案馆应通过削减前置审批、强制归档、智能+创新服务三个方面构建数字化管理新机制,实现智慧化活态城建档案馆的整体目标。通过完善依法行政、对接征信体系、技术迭代推进数字化进程,将智能化行政与智慧化服务并行,最终接入国家政务服务平台,实现全国"一网通办"的政务目标。     

The neutrophil-lymphocyte ratio to predict poor prognosis of critical acute myocardial infarction patients: a retrospective cohort study

IntroductionInflammation is closely related to adverse outcomes of acute myocardial infarction (AMI). This study aimed to evaluate whether neutrophil-lymphocyte ratio (NLR) can predict poor prognosis of critical AMI patients.Materials and methodsWe designed a retrospective cohort study and extracted AMI patients from the “Medical Information Mart for Intensive Care-III” database. The primary outcome was 1-year all-cause mortality. The secondary outcomes were 90-day and in-hospital all-cause mortalities, and acute kidney injury (AKI) incidence. The optimal cut-offs of NLR were picked by X-tile software according to the 1-year mortality and patient groups were created: low-NLR (< 4.8), high-NLR (4.8 - 21.1), and very high-NLR (> 21.1). Cox and modified Poisson regression models were used to evaluate the effect of NLR on outcomes in critically AMI patients.ResultsFinally, 782 critical AMI patients were enrolled in this study, and the 1-year mortality was 32% (249/782). The high- and very high-NLR groups had a higher incidence of outcomes than the low-NLR group (P < 0.05). The multivariate regression analyses found that the high- and very high-NLR groups had a higher risk of 1-year mortality (Hazard ratio (HR) = 1.59, 95% CI: 1.12 to 2.24, P = 0.009 and HR = 1.73, 95% CI: 1.09 to 2.73, P = 0.020), 90-day mortality (HR = 1.69, 95% CI: 1.13 to 2.54, P = 0.011 and HR = 1.90, 95% CI: 1.13 to 3.20, P = 0.016), in-hospital mortality (Relative risk (RR) = 1.77, 95% CI: 1.14 to 2.74, P = 0.010 and RR = 2.10, 95% CI: 1.23 to 3.58, P = 0.007), and AKI incidence (RR = 1.44, 95% CI: 1.06 to 1.95, P = 0.018 and RR = 1.34, 95% CI: 0.87 to 2.07, P = 0.180) compared with low-NLR group. NLR retained stable predictive ability in sensitivity analyses.ConclusionBaseline NLR is an independent risk factor for 1-year mortality, 90-day mortality, in-hospital mortality, and AKI incidence in AMI patients.