Oxidative stress and antioxidants in tubercular meningitis

Oxidative stress is implicated in the etiopathogenesis of a variety of human diseases. Therefore, in the present study, erythrocyte lipid peroxidation, percentage hemolysis, antioxidant enzymes viz., glutathione reductase, glutathione peroxidase, superoxide dismutase and plasma antioxidants viz., ceruloplasmin, vitamins A,E and C have been determined in 19 patients with tubercular meningitis (TBM) and 50 normals. Six patients who were treated with antibiotics were considered for the follow up. The statistical analysis was carried out by Mann Whitney U test and Wilcoxon rank sum test. Lipid peroxidation (P<0.02), percentage hemolysis (P<0.001) and plasma ceruloplasmin (P<0.0001) of TBM patients were significantly higher, whereas erythrocyte glutathione reductase (P<0.05) and plasma antioxidant vitamins A, E and C (P<0.01, P<0.05 respectively) were significantly lower than those of the controls. In the follow up patients the glutathione reductase and catalase levels were significantly high (P<0.05) compared to their pre-treated condition. Vitamin C and E levels have attained normal range. This study indicated that the blood antioxidant status of TBM patients which was low compared to controls improved after treatment, suggesting the role of free radicals in TBM.     

Session - 6 December 19, 2007 Respiratory signal transduction mechanisms

In a prospective study of 47 patients of subclinical hepatic encephalopathy in cirrhosis of liver, aged between 23 and 60 years, 49% showed Helicobacter pylori positivity by rapid urease test. The baseline characters of patients (mean age, serum creatinine, sereum albumin, serum bilirubin, prothrombin time) were similar among patients with and without Helicobacter infection in all the patients. There was no statistically significant difference in blood ammonia levels in either group of patients. Blood ammonia values showed good correlation with the functional state of liver function but they did not show statistically significant difference between two groups of patients in any of Child Pugh classes. It is concluded that Helicobacter pylori does not contribute significantly to blood ammonia levels and the severity of hepatic encephalopathy.     

Maternal and fetal indicators of oxidative stress in various obstetric complications

The present study demonstrates the incidence of increased lipid peroxidation and protein oxidation in both maternal and fetal erythrocytes as markers of oxygen radical activity in different complications of pregnancy. In fetuses born after premature rupture of membranes, lipid peroxidation was significantly elevated as indicated by increased malondialdehyde levels (p<0.05) as compared to controls. Proteolytic activity in the erythrocytes of mothers in this group was also significantly high (p<0.01). In patients delivered by lower segment cesarian section, lipid peroxidation and proteolytic activity in maternal erythrocytes were significantly high (p<0.05 and p<0.001 respectively). In patients with prolonged second stage of labour, lipid peroxidation and proteolytic activity in maternal erythrocytes was significantly higher than in controls (p<0.001 and p<0.05 respectively). In this group, endogenous protein damage due to oxidative stress was significantly high both in the mother and the fetus (p<0.001 and p<0.05 respectively).     

Two cases of hereditary fructose intolerance

Hereditary fructose intolerance is a rare cause of hepatic cirrhosis in the young. The disorder has a reported frequency of 1 in 20000 live births and no case has been reported from India so far. We report two cases of hereditary fructose intolerance, both with bilateral cataracts and one with cirrhosis of the liver.     

中外合作办学宿舍文化潜在课程及学生感受的实证分析——以广东某高校为个案

以广东省某中外合作办学高校为研究个案,对宿生发放了526份问卷,并对该校相关管理部门的负责人以及个别宿生进行了访谈,力求了解中外合作高校校方设计/引导的宿舍文化蕴含的潜在课程（含宿舍的物质文化、制度文化和精神文化三个层面）及学生对其的感受。研究结果表明：学生对中外合作办学宿舍文化潜在课程的整体评价大多数是正面而积极的,只有13.5%的学生表示不喜欢小镇的生活。大多数学生认同小镇生活,认为其让他们获得了独立的生活能力并学会了人际交往技巧,学生对于三个层面潜在课程功效的认同度由高到低分别为物质、制度、精神。     

青少年网络成瘾、父母监控与其社会适应的关系

以全国2139名中学生为被试,采用问卷法考查了青少年网络使用现状,并探讨了父母监控在网络成瘾与社会适应之间的作用.结果:(1)25.5%的父母经常指导孩子上网,结交新网友是报告最多的网络潜在危险行为.(2)网络成瘾存在显著的性别、年级差异.(3)在社会适应的积极维度,网络成瘾者得分显著低于非成瘾者;消极维度则与之相反.(4)父母监控在网络成瘾与社会适应的关系中起调节作用.     

Analysis of Bcl I and Xba I polymorphism in factor VIII gene to detect carriers of haemophilia a in Andhra Pradesh

The efficacy of two intragenic polymorphic markers of factor VIII gene has been examined in Andhra Pradesh population with a view to confirm/revise the strategy for carrier detection that would be precise and economical. The haemophilia A carrier was detected using Bcl I and Xba I polymorphic sites in intron 18 and 22 respectively. The cumulative efficiency of these two sites for detection of carriers is 100% since all 15 families tested were informative for one of these polymorphisms, thus confirming their usefulness for factor VIII gene mutations found in Andhra Pradesh.     

诗歌·民众·时代——读鲍勋诗歌兼谈当代诗歌的出路

鲍勋是十堰市一位非常有影响力的诗人,其诗作内容广泛、贴近时代、生活。因此受到当发民众的喜爱。在一个诗歌逐渐被边缘化的时代,能投入了自己全部热忱进行创作,并能有这样强烈的社会反响,鲍勋的诗歌在某种程度上为我们思考新诗的发展方向,提供了一些很好的思路。     

历史下的光影:20世纪30年代民国电影文化初探

电影作为一种文化产业,必定与时代的特征,包括政治、经济、社会生活的发展相关联。外国电影对当时民国时期的电影传播和宣传产生深远的影响,体现了国际性;民族意识的觉醒,推动着民族主义在民国电影业有着深入的体现。时代因素、社会因素、民众因素,都使得民国电影体现中西交融性。中国社会逐渐呈现出了中国传统文化艺术形式与西方文化艺术形式并存的格局。     

弥合数字鸿沟促进数字包容:信息社会中图书馆的新使命

为落实联合国2030年可持续发展目标,国际图联与一些国际组织共同发起“图书馆致力数字包容”的共同承诺和“行动呼吁”,国内外图书馆界领导及知名专家学者就“图书馆与数字包容”进行了讨论。饶权指出,随着现代技术的发展,数字鸿沟问题日益突显。中国国家图书馆研究提出建设“全国智慧图书馆体系”的工作思路,以期引领带动各级公共图书馆全面实现智慧转型,在促进数字包容方面发挥更加积极的作用;克里斯汀·麦肯齐阐述了国际图联在支持联合国2030年议程和可持续发展目标方面的工作,特别是目标第16条:“构建和平与包容的社会,使人人享有公正,提高政府机构效率和能力,强调政府和图书馆必须成为数字包容的积极推动者”;杰拉德·莱特纳指出,促进数字包容的任何努力都需要考虑三个方面——互联、内容和能力。缺乏任何一个方面,都不可能完全实现数字包容。图书馆作为社区中心的公共空间、内容的储存空间和门户,以及经验丰富的信息素养教育者,在更广泛的政府战略中都可以发挥自己独特的作用;陈超指出,历史和现实、理论和实践早就告诉我们,公共图书馆肩负着促进人类社会包容性发展的义不容辞的使命。为此公共图书馆必须承担起“弥合数字鸿沟,促进数字包容”的社会责任,让每一个人有机会上网、为每一个人赋能、让每一个人能平等获取信息知识;吴建中认为,我国图书馆界应积极配合国际图联的呼吁与倡议,并发出我国图书馆界强有力的声音。第一,大力宣传我国在保障公民获取基本公共文化服务权益方面的政策及举措。第二,积极推广互联网和数字技术在图书馆的应用。第三,继续提升媒介和信息素养服务的质量;于良芝从个人信息世界的概念出发思考数字鸿沟现象及图书馆的作用,揭示了数字鸿沟的复杂性及社会包容与数字包容的互为条件性,认为这为公共图书馆参与数字包容建设开辟了更广阔的空间;肖珑表示,支持国际图联(IFLA)关于数字包容声明的提出,中国高校图书馆应清醒地认识到信息贫富分化问题的存在,并努力缩小地区差距,保护不同群体利益,促进高等教育的内涵式发展;阿曼达·里德与金·汤普森认为,当危机、变革和挑战来临之际,也是我们努力前行之时,并以一所美国图书馆为例,显示了在新冠疫情这样的危机面前,公共图书馆如何满足当地居民需要,支持社区朝着更加数字包容的社会可持续地发展;金武刚认为,图书馆应当加强科普功能,开发新媒体产品,融入公共传播平台,帮助社会民众辨别网络信息真伪,查询获取正确信息,解决数字包容深层次问题;吴丹与刘静基于技术环境变化的背景,以人与技术的交互为焦点,从“技术→人”与“人→技术”两条路径对数字包容内涵进行扩展并提出了图情领域工作的发展策略。