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71.
The correlation between antioxidant capacity and oxidative damage during aging has been reported in several tissues in different
species. Glutathione-S-transferases (GST) can metabolise endogenous and exogenous toxins and carcinogens by catalysing the
conjugation of diverse electrophiles with reduced glutathione (GSH). We observe a significant (P < 0.001) increase in plasma GST activity as a function of human age (r = 0.5675). A significant (P < 0.001) positive correlation (r = 0.8979) is observed between GST activity and total plasma antioxidant potential measured
as ferric reducing ability of the plasma (FRAP). GST activity and red cell intracellular GSH also show a significant positive
correlation (r = 0.7014). We hypothesize that the increased activity of plasma GST is a manifestation of increased generation
of ROS and a concomitant decrease in the level of plasma antioxidant capacity during aging. 相似文献
72.
Every individual should be entrusted with an internal driver to strive their best towards achieving their potential and to manifest their performance through innovative means. This can be reached only under circumstances where the abstract human values and principles are recognized and indoctrinated in the culture. The strategies discussed in this article will serve as input in proposing the areas of focus toward the practice of human governance. 相似文献
73.
74.
Ujjal Kumar Sur 《Resonance》2010,15(2):154-164
In Raman spectroscopy, inelastic scattering of photons from an atomor molecule in chemical entities is utilized to analyze
the composition of solids, liquids and gases. However, the low cross-section limits its applications. The introduction of
surface-enhancedRamanspectroscopy in 1974has attracteda lot of attention fromresearchers due to the large enhancement of weak
Raman signal,which facilitates identification in chemical and biological systems. Recently, single-molecule Raman scattering
has enhanced the detection sensitivity limit of Raman Spectroscopy. 相似文献
75.
The world of mobile communications is poised for yet another disruptive transformation – the introduction of 5G. It will change the way mobile phones communicate. New technologies at the device level and novel network architectures to manage them will be soon seen everywhere. This article explores what 5G is all about. It also talks briefly about the preparations underway across the globe to deploy 5G by 2020. 相似文献
76.
In this article, we report some experimental results on the behaviour of the flame of a candle kept at the bottom of a glass tube, which is open at the top and closed at the bottom. Thus, the supply of oxygen for the continuous burning of the flame is possible only from the top open end of the tube. We find that the candle burns steadily below a critical tube height. Above this height, the flame oscillates in size, and a further increase in tube height leads to the flame extinguishing quickly. 相似文献
77.
Rajesh Kumar Kori Manish Kumar Singh Abhishek Kumar Jain Rajesh Singh Yadav 《Indian journal of clinical biochemistry : IJCB》2018,33(4):372-381
The problem of pesticides is not new and its exposure to human due to indiscriminate use is largely associated with the health related problems including neurotoxicological alterations. High levels of pesticide residues and their metabolites in the dietary constituents, food materials, maternal blood, cord blood, placenta breast milk have been reported and linked to alterations in birth weight, crown heel length, head circumference, mid-arm circumference and ponderal index of the neonates. Epidemiological studies have suggested that exposure of pesticide to human could be a significant risk factor for neurological disorders, including Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. Cholinergic and non-cholinergic dysfunctions in pesticide exposed population, especially in children have also been frequently reported in recent years. Developmental neurotoxicity is another concern in the area where pregnant are more prone towards its exposure and which results in the abnormalities in the fetus. In view of the increasing risk of human health through pesticide exposure, the present review has been focused on the studies pertaining to pesticide induced neurochemical alterations and associated behavioral abnormalities in farm workers which could establish a possible link between the its exposure and associated health hazards. 相似文献
78.
Gaurav Chikara Pramod Kumar Sharma Pradeep Dwivedi Jaykaran Charan Sneha Ambwani Surjit Singh 《Indian journal of clinical biochemistry : IJCB》2018,33(2):121-131
Prevalence of diabetes mellitus, a chronic metabolic disease characterized by hyperglycemia, is growing worldwide. The majority of the cases belong to type 2 diabetes mellitus (T2DM). Globally, India ranks second in terms of diabetes prevalence among adults. Currently available classes of therapeutic agents are used alone or in combinations but seldom achieve treatment targets. Diverse pathophysiology and the need of therapeutic agents with more favourable pharmacokinetic-pharmacodynamics profile make newer drug discoveries in the field of T2DM essential. A large number of molecules, some with novel mechanisms, are in pipeline. The essence of this review is to track and discuss these potential agents, based on their developmental stages, especially those in phase 3 or phase 2. Unique molecules are being developed for existing drug classes like insulins, DPP-4 inhibitors, GLP-1 analogues; and under newer classes like dual/pan PPAR agonists, dual SGLT1/SGLT2 inhibitors, glimins, anti-inflammatory agents, glucokinase activators, G-protein coupled receptor agonists, hybrid peptide agonists, apical sodium-dependent bile acid transporter (ASBT) inhibitors, glucagon receptor antagonists etc. The heterogeneous clinical presentation and therapeutic outcomes in phenotypically similar patients is a clue to think beyond the standard treatment strategy. 相似文献
79.
Pragati Priyadarshinee Rakesh D. Raut Manoj Kumar Jha Sachin S. Kamble 《The Journal of High Technology Management Research》2017,28(2):221-245
The purpose of this research article is to identify the critical success criteria/factors that affect the cloud computing adoption and examine structure, reliability and validity of the criteria in the SMEs industry. This study considers nine types of criteria/factors with fifty-one sub-criteria, which have somewhat previously been used, and creates a ranking model that offers decision makers to measure the prior implementation of cloud computing adoption. A questionnaire-based survey research was used to collect data from 110 firms belonging to the SMEs industry in India. In this paper, the data collected was analysed by an integrated approach. Firstly, an Analytic Hierarchy Process approach was applied to find the significant fact of each criterion as the assessable indices of the cloud computing adoption. Secondly, an Exploratory Factor Analysis and Confirmatory Factor Analysis were used to examine structure, reliability and validity of the criteria. The data was tabulated in a Microsoft Excel sheet and then imported in SPSS (Statistical Package for the Social Sciences version 20) for analysis. The findings discovered that ‘Security and Privacy’, ‘Organizational Risk’, ‘Sharing and Collaboration’, ‘Confidentiality’, and ‘Integrity’ have a major effect on the adoption of cloud computing. The research was conducted in the SMEs industry in India, which may limit the generalizability of the findings. The findings and recommendations offer cloud computing service providers as well as users with a better understanding of what affects the cloud computing adoption feature, with a relevant understanding of the current scenario. The research aided in the application of the new technology of cloud computing adoption in the SMEs industry in India through the use of a wide range of criteria. The findings also help organizations study their information technology investments when applying cloud computing. 相似文献
80.
The present paper proposes two new schemes of sensor fault estimation for a class of nonlinear systems and investigates their performances by applying these to satellite control systems. Both of the schemes essentially transform the original system into two subsystems (subsystems 1 and 2), where subsystem-1 includes the effects of system uncertainties, but is free from sensor faults and subsystem-2 has sensor faults but without any uncertainties. Sensor faults in subsystem-2 are treated as actuator faults by using integral observer based approach. The effects of system uncertainties in subsystem-1 can be completely eliminated by a sliding mode observer (SMO). In the first scheme, the sensor faults present in subsystem-2 are estimated with arbitrary accuracy using a SMO. In the second scheme, the sensor faults are estimated by designing an adaptive observer (AO). The sufficient condition of stability of the proposed schemes has been derived and expressed as a linear matrix inequality (LMI) optimization problem and the design parameters of the observers are determined by using LMI techniques. The effectiveness of the schemes in estimating sensor faults is illustrated by considering an example of a satellite control system. The results of the simulation demonstrate that the proposed schemes can successfully estimate sensor faults even in the presence of system uncertainties. 相似文献