Convergent genomic signatures of high-altitude adaptation among domestic mammals

Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10orf67, which underwent positive selection in three of the domestic mammals. Our data provide an insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway.     

Machine learning-enabled multiplexed microfluidic sensors

High-throughput, cost-effective, and portable devices can enhance the performance of point-of-care tests. Such devices are able to acquire images from samples at a high rate in combination with microfluidic chips in point-of-care applications. However, interpreting and analyzing the large amount of acquired data is not only a labor-intensive and time-consuming process, but also prone to the bias of the user and low accuracy. Integrating machine learning (ML) with the image acquisition capability of smartphones as well as increasing computing power could address the need for high-throughput, accurate, and automatized detection, data processing, and quantification of results. Here, ML-supported diagnostic technologies are presented. These technologies include quantification of colorimetric tests, classification of biological samples (cells and sperms), soft sensors, assay type detection, and recognition of the fluid properties. Challenges regarding the implementation of ML methods, including the required number of data points, image acquisition prerequisites, and execution of data-limited experiments are also discussed.     

Towards a Model of Intercultural Communicative Competence in Iranian EFL Context: Testing the Role of International Posture,Ideal L2 Self,L2 Self-Confidence,and Metacognitive Strategies

ABSTRACT

This study aimed to present a model of intercultural communicative competence (ICC) by incorporating international posture, motivational disposition (ideal L2 self), second language (L2) self-confidence, and metacognitive learning strategies. To this end, 150 Iranian L2 learners, selected through convenience sampling procedure, took part in the research. The findings of structural equation modelling revealed that the proposed model showed adequate fit to the data, implying that the model is appropriate in Iranian English as a foreign language (EFL) context. Also, the results indicated that learners with a high level of international posture are more likely to bridge the gap between their present and ideal selves. This was, additionally, argued that internationally oriented and ideally motivated learners become confident of their abilities to get engaged in interaction with L2 target communities. Furthermore, metacognitive learning strategies were found to be directly associated with ICC, implicating that the learners who continuously reflect on their learning and evaluate their performances are more prone to have a higher level of ICC. Finally, suggestions were offered for language teachers and policy-makers to inspire their learners to be more competent in communication with people of other cultures and languages.     

Facilitators and Barriers to Movement Integration in Elementary Classrooms: A Systematic Review

Purpose: A systematic review was conducted to identify facilitators and barriers to movement integration (MI) in elementary school classrooms. Method: Online databases (Educational Resources Information Center, Google Scholar, PsycINFO, and PubMed) served as data sources for the study. Following the PRISMA guidelines, relevant published research on MI was identified and screened for inclusion in a qualitative synthesis. Content analysis of the included articles (N = 28) was used to identify themes of MI facilitators and barriers. Facilitators and barriers were then categorized using a social-ecological framework. Results: A total of 12 themes of MI facilitators and barriers were identified and categorized into two social-ecological levels: institutional factors (e.g., administrative support, resources) and intrapersonal factors (e.g., teacher confidence, ease of implementation). Conclusion: This review can inform research and practice aimed at supporting the implementation of MI in elementary classrooms.     

Identity exploration,identity confusion,and openness as predictors of multicultural ideology

Research has indicated benefits to individuals and society of holding a multicultural versus colorblind ideology. This cross-sectional study tested the association of endorsement of multiculturalism with the individual difference constructs of identity exploration, identity confusion, and openness. Participants were 188 college students who completed a survey. Multiple regression analyses indicated that identity exploration, identity confusion, and openness independently predicted multicultural ideology. Additionally, identity exploration and identity confusion interacted such that identity exploration was associated with multiculturalism when identity confusion was low, but not when identity confusion was high. These findings indicate that general individual differences in personality and identity are predictive of cultural-related attitudes, and have implications for the design of interventions aimed at increasing multiculturalism.     

The ‘Non‐dit’ in the Zenana: representations of Muslim women in Islamic canonical texts,the neo‐colonial imagination and a feminist response from Bangladesh

Abstract

This essay recognizes that representations of the ‘Muslim woman’ as the Othered ‘object’ of the ‘Western’ gaze and the domesticated ‘object’ which the Islamic apologists strive hard to defend, are both constructions and false antitheses of each other. It seeks not the ‘truth’ regarding the Muslim women in the world of social reality but to examine how various representations of the women are constructed and to what effects and consequences these representations are mobilized. The essay proceeds in three stages. The first stage shows how the patriarchy mobilizes the Qur’an and the Hadith in order to construct the woman as the negative, the inessential and the abnormal of the man so as to exert complete subordination over her. However, the very act of attempting to mute the woman in Islam is the most strident proof that she is engaged in resistance against patriarchal control and the degree of resistance must be judged by the degree of patriarchal control. The second stage demonstrates how patriarchy operates in colonial and neo‐imperial landscape: it legitimizes the appropriation of Muslim woman ‘possessed’ by the Other (as exemplified by the orientalist seduction fantasy in William Dalrymple’s The White Mughals), but, haunted by the fear of rape and anxieties regarding the sexuality of the White woman possessed by the Self, it attempts to maintain strict control over her (as in the cases of Miss Wheeler in the ‘Mutiny’ of 1857 and Private Jessica Lynch in the Iraq War). This struggle over the feminine body is perfectly in line with Islam’s hyper‐anxiousness to hide the female body and rigorously ensure monopolic possession over her. The third stage shows how Taslima Nasreen, a late‐20th century feminist from Bangladesh, speaks the unspoken and thereby attempts to subvert the normative representation of the muted women in her autobiographical novella, entitled āmār Meyebelā. In thus examining the representations of the Muslim women, this essay seeks an alternative ‘third space of enunciation’ and takes a distinct political stand located outside of the axis of the dichotomy of the ‘Western’ gaze and the construction of the Islamic theologians.     

Older Women and Lower Self-Rated Health

Several studies have found that older women report lower self-rated health than men. However, it is not clear why older women are more likely to report poor self-rated health than older men. Data for this study came from a national cross-sectional survey, Mental Health and Quality of Life of Older Malaysians (MHQoLOM). Included in the survey were 2980 respondents consisting of Malaysians aged 60 years and over, with both men (n = 1428) and women (n = 1552) represented. Results of t-tests showed older men expressed significantly higher levels of self-rated health and self-esteem than women (p < .01). Separate multivariate regression by gender revealed that age, life-threatening problems, and self-esteem were highly significant predictors of self-rated health among older men and women and explained 18.4% of variance in self-rated health for men and 18.2% for women. In the last step we examined the main effects of gender on self-rated health using General Linear Models (GLM) Univariate by adjusting for age, life-threatening problems, and self-esteem. Results showed an insignificant difference in self-rated health between older men and women (F _(1,2715) = 2.26, P = 0.13) only after adjusting for self-esteem. It can be concluded that self-esteem affects responses to self-rated health of older men and women.