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Eric R. Muoz Jaclyn B. Caccese Brittany E. Wilson Kyle T. Shuler Fernando V. Santos Carolina T. Cabn John J. Jeka Dianne Langford Matthew B. Hudson 《运动与健康科学(英文)》2021,10(2):122-130
BackgroundConsidering the potential cumulative effects of repetitive head impact (HI) exposure, we need sensitive biomarkers to track short- and long-term effects. Circulating small extracellular vesicles (sEVs) (<200 nm) traffic biological molecules throughout the body and may have diagnostic value as biomarkers for disease. The purpose of this study was to identify the microRNA (miRNA) profile in circulating sEVs derived from human plasma following repetitive HI exposure.MethodsHealthy adult (aged 18–35 years) soccer players were randomly assigned to one of 3 groups: the HI group performed 10 standing headers, the leg impact group performed 10 soccer ball trapping maneuvers over 10 min, and the control group did not participate in any soccer drills. Plasma was collected before testing and 24 h afterward, and sEVs were isolated and characterized via nanoparticle tracking analysis. Next-generation sequencing was utilized to identify candidate miRNAs isolated from sEVs, and candidate microRNAs were analyzed via quantitative polymerase chain reaction. In silico target prediction was performed using TargetScan (Version 7.0; targetscan.org) and miRWalk (http://mirwalk.umm.uni-heidelberg.de/) programs, and target validation was performed using luciferase reporter vectors with a miR-7844-5p mimic in human embryonic kidney (HEK) 293T/17 cells.ResultsPlasma sEV concentration and size were not affected across time and group following repetitive HI exposure. After 24 h, the HI read count from next-generation sequencing showed a 4-fold or greater increase in miR-92b-5p, miR-423-5p, and miR-24-3p and a 3-fold or greater decrease in miR-7844-5p, miR-144-5p, miR-221-5p, and miR-22-3p. Analysis of quantitative polymerase chain reaction revealed that leg impact did not alter the candidate miRNA levels. To our knowledge, miR-7844-5p is a previously unknown miRNA. We identified 8 miR-7844-5p mRNA targets: protein phosphatase 1 regulatory inhibitor subunit 1B (PPP1R1B), LIM and senescent cell antigen-like domains 1 (LIMS1), autophagy-related 12 (ATG12), microtubule-associated protein 1 light chain 3 beta (MAP1LC3B), integrin subunit alpha-1 (ITGA1), mitogen-activated protein kinase 1 (MAPK1), glycogen synthase kinase 3β (GSK3β), and mitogen-activated protein kinase 8 (MAPK8).ConclusionCollectively, these data indicate repetitive HI exposure alters plasma sEV miRNA content, but not sEV size or number. Furthermore, for the first time we demonstrate that previously unknown miR-7844-5p targets mRNAs known to be involved in mitochondrial apoptosis, autophagy regulation, mood disorders, and neurodegenerative disease. 相似文献
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The case is considered in which, during the operation of an optimal control system, the optimizer, in addition to applying his usual control, may switch structures. Necessary and sufficient conditions are derived and emphasis is placed on the special characteristics of this problem. Continuous and discrete time set-ups are considered and the separation principle is shown not to hold for the linear quadratic case in the presence of noise. 相似文献
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Dynamic retinoscopy has suggested that near vision may be more acute than far vision during early infancy. To test this, acuity thresholds were determined by presenting square wave gratings in a preference paradigm to 1- and 2-month-old human infants at 4 viewing distances. Gratings were paired with unpatterned fields; direction of first fixation was the dependent measure. Infants exhibited the same acuity at each of the distances at which gratings were presented. The results were interpreted as compatible with the fact that considerable optical defocusing does not seriously affect a visual system, such as the infant's, that is sensitive only to low spatial frequencies. 相似文献
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P. Hammond 《Journal of The Franklin Institute》1978,306(2):133-157
Electromagnetic fields can be treated as systems in which the field equations are the equations of equilibrium. This formulation draws the subject into the unified approach of mechanics. Close analogies to potential and kinetic energy exist and these can be used to provide double bounds to the electromagnetic energy. 相似文献
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This paper introduces a polynomial operator called the DT-polynomial as a novel approach to network flow problems. The class of networks dealt with is time-varying in the sense that the capacity, cost, and travel-time of each edge may vary in discrete time. The Dt-polynomial is a polynomial in two operators, D (delay) and T (time), which is used for describing the time-varying transmission characteristics. The paper starts with the mathematics involving the DT-polynomials. A new shortest arrival route algorithm is presented, and its computational complexity is found to be favorable in comparison with others such as Dijkstra's method and the potential method derived from Ford-Fulkerson's technique. Furthermore, a dynamic flow problem is formulated and analyzed in terms of DT-polynomials, and a latest-departure earliest-arrival schedule is given. Finally, a modified DT-polynomial is applied to digital filter networks. 相似文献
70.
It is often desirable to represent carrier distribution systems by networks so that analysis can be made to predict the behavior of these systems. Modeling of two canonical carrier distribution systems, the star-shaped system and the parallel-wire system by networks was carried out in this paper. The representation is given in terms of lumped parameters when the lengths of the carrier lines are short and it is given in terms of lumped and distributed parameters when the lengths of the carrier lines are long. 相似文献