Electron-hole hybridization in bilayer graphene

Band structure determines the motion of electrons in a solid, giving rise to exotic phenomena when properly engineered. Drawing an analogy between electrons and photons, artificially designed optical lattices indicate the possibility of a similar band modulation effect in graphene systems. Yet due to the fermionic nature of electrons, modulated electronic systems promise far richer categories of behaviors than those found in optical lattices. Here, we uncovered a strong modulation of electronic states in bilayer graphene subject to periodic potentials. We observed for the first time the hybridization of electron and hole sub-bands, resulting in local band gaps at both primary and secondary charge neutrality points. Such hybridization leads to the formation of flat bands, enabling the study of correlated effects in graphene systems. This work may provide a novel way to manipulate electronic states in layered systems, which is important to both fundamental research and application.     

HLA Gene in 5 Cases of Liver Injury Related to Baikal Skullcap

HLA association with drug-induced liver injury has recently been pointed out about multiple medicines. The aim of this study was to evaluate relationship between HLA gene and liver injury related to Baikal skullcap-containing Kampo medicines (BSCK). We previously examined HLA genes in 3 cases of BSCK-induced liver injury. Recently we could encounter 2 cases diagnosed as “definitely-related case” of BSCK-induced liver injury. HLA genes of the 2 cases were analyzed by Sequencing Based Typing method with Next Generation Sequencer at HLA Laboratory in Kyoto. HLA-DPA1*02:02:02 and DPB1*05:01:01 were observed in the 2 cases: concordance was not observed in HLA-A, B, C, DRB1, DRB4, DQA1, or DQB1. The previous 3 cases of BSCK-induced liver injury had the same allele type to the 2 cases only in HLA-DPA1. Putting all these together, HLA-DPA1*02:02:02 was observed in common among 5 cases of BSCK-induced liver injury. HLA-DPA1*02:02:02 is possibly associated with BSCK-induced liver injury.     

On simplified Hurwitz stability conditions for low-degree weighted diamond polynomials

In this paper, the results on the stability of a weighted diamond of polynomials which was studied by Kharitonov and Tempo (Systems Control Lett. 22 (1994)) are simplified for low-order polynomials. Specifically, for n=3 and 4, the number of polynomials required to check the stability is four and six, respectively, instead of eight. Further, diamond of polynomials which were studied by Barmish et al. (IEEE Trans. Automat. Control AC-37 (9) (1992)) are also investigated.     

Stabilization irrespective of bounds of uncertain variations for linear uncertain systems with delays

In this study, the stabilizability irrespective of the bounds of uncertain parameters and time delays is investigated for linear uncertain delay systems. For uncertain systems without delays, a linear time-varying or time-invariant uncertain system has been shown to be stabilizable independent of the bounds of uncertain variations if and only if the system has a particular geometric configuration called an antisymmetric stepwise configuration (ASC) or a generalized antisymmetric stepwise configuration (GASC), respectively. In this study, fundamental approaches to investigating the stabilizability of delay systems with specific uncertainty structures such as ASCs or GASCs are presented. For a class of 3-dimensional systems, it is shown here that if a linear time-varying or time-invariant uncertain delay system has an ASC or a GASC, respectively, then the system can be stabilized, however large the given bounds of delays and uncertain parameters might be.     

Adverse effects of energy restriction on myogenic enzymes in judoists

In this study, we examined the effects of weight reduction by restricting energy intake on muscle function and serum concentrations of myogenic enzymes in judoists. Twenty-seven male judoists aged 19.3±0.6 years (mean±s) were divided into three groups based on the extent of body weight reduction: high weight reduction (height 1.70±0.05?m, body mass 78.5 ±13.6?kg), low weight reduction (height 1.70±0.05?m, body mass 80.7±13.1?kg) and a group that maintained body weight while continuing to perform exercise training (height 1.78± 0.07?m, body mass 78.7±8.8?kg). Body composition, blood biochemistry, energy intake and anaerobic power were assessed on four occasions: 20 days (baseline data), 4 days and 1 day before and 7 days after competition. Compared with baseline, body mass and fat-free mass were significantly lower 1 day before competition in the high and low weight reduction groups (both P?<0.01); these changes persisted for 7 days after competition in the high weight reduction group. Serum creatine kinase was significantly elevated 1 day before competition in all groups (all P?<0.05), and remained higher 7 days after competition in both the high and low weight reduction groups. Compared with baseline, maximal anaerobic power was significantly lower 1 day before competition only in the high weight reduction group (P?<0.01). Our results suggest that energy restriction in addition to intense exercise training before major competition has an adverse effect on anaerobic power and elevates serum creatine kinase concentration, leading to an impairment of muscular function and an increased susceptibility of muscle tissue to injury.     

The effects of resistance exercise with and without different degrees of blood-flow restriction on perceptual responses

The aim was to compare exercise with and without different degrees of blood-flow restriction on perceived exertion (RPE) and discomfort. Participants were assigned to Experiment 1, 2, or 3. Each completed protocols differing by pressure, load, and/or volume. RPE and discomfort were taken before and after each set. For pressure and RPE, the 20% one repetition maximum (1RM) blood-flow restriction conditions were affected by increasing the pressure from 40% to 50% blood-flow restriction (~12 vs. ~14). This did not appear to happen within the 30% 1RM blood-flow restriction conditions or the higher pressures in the 20% 1RM conditions. The similar RPE between 20% and 30% 1RM to failure was expected given both were to failure. For discomfort, ratings were primarily affected by load at the lowest pressure. Increasing pressure to 50% blood-flow restriction increased discomfort at 20% 1RM (~2.6 vs. ~4). There was a further increase when increasing to 60% blood-flow restriction (~4 vs. ~4.8). The high-load condition had the lowest discomfort, while ratings were highest with 20% 1RM to failure. In conclusion, exercise with blood-flow restriction does not appear to augment the perceptual response observed with low-load exercise to failure.     

软开关脉宽调制变频技术

In this paper, a new soft-switching inverter using a minimum number of devices, and a new PWM (pulse-width modulation) method suitable for 3-phase soft-switching inverters are proposed. The circuit is used as an interface between the DC supply and the conventional voltage source of a PWM inverter. The number of switching operations can be reduced by using the PWM strategy. Increasing the amplitude of the fundamental component contained in the output waveform results in an effective utilization of the DC supply, a reduction of nominated capacity of the inverter elements, and a reduction of switching loss in the switching devices. Supported by National Natural Science Foundation of China (59977012)     

Combined effects of pre-cooling and water ingestion on thermoregulation and physical capacity during exercise in a hot environment

The aim of the present study was to determine the combined effects of pre-cooling and water ingestion on thermoregulatory responses and exercise capacity at 32 degrees C and 80% relative humidity. Nine untrained males exercised for 60 min on a cycle ergometer at 60% maximal oxygen uptake (VO2max) (first exercise bout) under four separate conditions: No Water intake, Pre-cooling, Water ingestion, and a combination of pre-cooling and water ingestion (Combined). To evaluate the efficacy of these conditions on exercise capacity, the participants exercised to exhaustion at 80% VO2max (second exercise bout) following the first exercise bout. Rectal and mean skin temperatures before the first exercise bout in the Pre-cooling and Combined conditions were significantly lower than in the No Water and Water conditions. At the end of the first exercise bout, rectal temperature was lower in the Combined condition (38.5 +/- 0.1 degrees C) than in the other conditions (No Water: 39.1 +/- 0.1 degrees C; Pre-cooling: 38.7 +/- 0.1 degrees C; Water: 38.8 +/- 0.1 degrees C) (P < 0.05). Heat storage was higher following pre-cooling than when there was no pre-cooling (P < 0.05). The final rectal temperature in the second exercise bout was similar between the four conditions (39.1 +/- 0.1 degrees C). However, exercise time to exhaustion was longer (P < 0.05) in the Combined condition than in the other conditions. Total sweat loss was less following pre-cooling than when there was no pre-cooling (P < 0.001). Evaporative sweat loss in the Water and Combined conditions was greater (P < 0.01) than in the No Water and Pre-cooling conditions. Our results suggest that the combination of pre-cooling and water ingestion increases exercise endurance in a hot environment through enhanced heat storage and decreased thermoregulatory and cardiovascular strain.