显微网络互动多媒体系统在遗传学实验教学中的应用效果

在遗传学实验教学中运用显微网络互动多媒体系统,弥补了单纯使用显微镜的不足;教师的演示、学生的反馈更及时,教师的指导更具有针对性,并加强了信息沟通和互动;强大的图片采集、保存与处理功能,有利于激发学生的实验兴趣,有利于加深对理论知识的理解;多画面的监控转播功能,可控制教学进度,提高实验课程效率和教学效果。     

论中外合作办学的可持续发展

当前,中外合作办学面临新的机遇与挑战。要实现中外合作办学可持续发展,必须遵循中外合作办学的基本规律,坚持引进优质教育资源的原则,坚持公益性原则,完善评估机制,加强质量监控与管理,坚持规范办学,严格依法管理。     

高职电子类专业“CDIO实践教学模式”探索

分析了传统高职电子类专业实践教学存在的主要问题,建立并实施了CDIO实践教学模式。结果表明：＂CDIO实践教学模式＂能够以接近电子工程实际所涉及的综合设计项目为主要载体,结合电子类实践环节的教学,使学生在CDIO的全过程中不断地在电子工程基础知识、个人能力、团队能力和工程系统能力4个方面得到全面的训练和提高。     

Convergent genomic signatures of high-altitude adaptation among domestic mammals

Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10orf67, which underwent positive selection in three of the domestic mammals. Our data provide an insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway.     

基于GIS的横断山区地形起伏度与人口和经济的关系

地形起伏度是影响山区人口分布和经济发展的关键因素。以横断山区大尺度ASTER GDEM为数据源,基于GIS的窗口递增分析原理,采用均值变点法科学分析平均地形起伏度的最佳统计面积并对其进行分级和相关性分析,得出实验区最佳分析窗口面积为0。202 5 km²,省域之间地形起伏度差异明显,省内差异不明显,相关性较高。同时,采用空间分析技术、统计学方法以及PCA排序法,分析地形起伏度与人口、经济的关系。研究结果表明：随着地形起伏度的增大,人口密度逐渐降低,当达到3。7以后人口密度趋于一个固定值;地形起伏度与第三产业占GDP比重的负相关性最大,与城镇化率的负相关性较小,与人均GDP的负相关性最小。     

Injectable hybrid inorganic nanoscaffold as rapid stem cell assembly template for cartilage repair

Cartilage injuries are often devastating and most cannot be cured because of the intrinsically low regenerative capacity of cartilage tissues. Although stem-cell therapy has shown enormous potential for cartilage repair, the therapeutic outcome has been restricted by low survival rates and poor chondrocyte differentiation in vivo. Here, we report an injectable hybrid inorganic (IHI) nanoscaffold that facilitates fast assembly, enhances survival and regulates chondrogenic differentiation of stem cells. IHI nanoscaffolds that strongly bind to extracellular matrix (ECM) proteins assemble stem cells through synergistic 3D cell–cell and cell–matrix interactions, creating a favorable physical microenvironment for stem-cell survival and differentiation in vitro and in vivo. Additionally, chondrogenic factors can be loaded into nanoscaffolds with a high capacity, which allows deep, homogenous drug delivery into assembled 3D stem-cell-derived tissues for effective control over the soluble microenvironment of stem cells. The developed IHI nanoscaffolds that assemble with stem cells are injectable. They also scavenge reactive oxygen species and timely biodegrade for proper integration into injured cartilage tissues. Implantation of stem-cell-assembled IHI nanoscaffolds into injured cartilage results in accelerated tissue regeneration and functional recovery. By establishing our IHI nanoscaffold-templated 3D stem-cell assembly method, we provide a promising approach to better overcoming the inhibitory microenvironment associated with cartilage injuries and to advance current stem-cell-based tissue engineering.     

区域一体化对城市创新能力驱动研究——基于长三角的实证分析

长三角更高质量一体化发展标志着各种资源要素在长三角区域内的配置效率将进一步提升,有利于形成更强的区域创新能力。本文基于2005—2017年长三角城市统计数据,考察了区域一体化对城市创新能力的驱动作用,并对其中的影响机制和异质性进行了深入分析。结果显示：(1)区域一体化对长三角城市创新能力具有显著的促进作用。(2)机制分析发现,一体化伴随的产业集聚并未形成创新能力提升机制,但一体化推动的区域内部产业转移机制有效提升了城市创新能力。(3)异质性分析表明,长三角区域一体化对非核心城市、欠发达城市、低财政分权城市具有更为显著的城市创新能力驱动作用。     

Water molecules bonded to the carboxylate groups at the inorganic–organic interface of an inorganic nanocrystal coated with alkanoate ligands

High-quality colloidal nanocrystals are commonly synthesized in hydrocarbon solvents with alkanoates as the most common organic ligand. Water molecules with an approximately equal number of surface alkanoate ligands are identified at the inorganic–organic interface for all types of colloidal nanocrystals studied, and investigated quantitatively using CdSe nanocrystals as the model system. Carboxylate ligands are coordinated to the surface metal ions and the first monolayer of water molecules is found to bond to the carboxylate groups of alkanoate ligands through hydrogen bonds. Additional monolayer(s) of water molecules can further be adsorbed through hydrogen bonds to the first monolayer of water molecules. The nearly ideal environment for hydrogen bonding at the inorganic–organic interface of alkanoate-coated nanocrystals helps to rapidly and stably enrich the interface-bonded water molecules, most of which are difficult to remove through vacuum treatment, thermal annealing and chemical drying. The water-enriched structure of the inorganic–organic interface of high-quality colloidal nanocrystals must be taken into account in order to understand the synthesis, processing and properties of these novel materials.     

网络舆论对伊朗突发新闻关注热点分析——以少将遇袭和导弹袭击事件中的微博为基础

本文探究网络舆论对伊朗突发新闻的关注热点,进而透过社交媒体分析网络舆论对国际热点事件的关注倾向.以含有关键词"伊朗少将遇袭"、"伊朗导弹袭击"和"伊朗"的所有微博作为研究数据,基于词频统计和LDA主题模型提取主题,从文本特征角度分析网络舆论对伊朗局势的关注热点.本研究对基于新浪微博数据检索到的文本内容进行分析发现,网络...     

对创建节约型大学的几点思考

建设节约型大学是建设节约型社会的重要组成部分。本文借鉴新公共管理学和新制度经济学理论,针对我国高等教育发展仍未从根本上改变高投入、高消耗、低效率的粗放型增长方式,稀缺高等教育资源一直存在显性和隐性浪费等问题,对创建节约型大学进行了深层次思考;创建节约型大学是高等教育资源优化配置的必然选择;排除教育产权体制性障碍是解决高等教育资源浪费问题的核心;创建节约型大学必须转变观念,为建设节约性社会作贡献。