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Obesity is a disease that has become an epidemic in economically developed countries,and manifests itself at increasing rates in economically developing countries.Obesity is associated with a variety of comorbidities,such as metabolic disease,diabetes,cardiovascular diseases,and musculoskeletal disorders,all resulting in tremendous costs to health care systems around the world,a reduced capacity for work,and reduced quality of life for people with obesity,coupled with physical inactivity,thereby producing a vicious circle of inactivity-induced diseases that enhances obesity. 相似文献
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Kelsey H.Collins Graham Z.MacDonald David A.Hart Ruth A.Seerattan Jaqueline L.Rios Raylene A.Reimer Walter Herzog 《运动与健康科学(英文)》2020,9(2):132-139,197
Background:Osteoarthritis is one of the leading causes of pain and disability worldwide,and a large percentage of patients with osteoarthritis are individuals who are also obese.In recent years,a series of animal models have demonstrated that obesity-inducing diets can result in synovial joint damage(both with and without the superimposition of trauma),which may be related to changes in percentage of body fat and a series of low-level systemic inflammatory mediators.Of note,there is a disparity between whether the dietary challenges commence at weaning,representing a weanling onset,or at skeletal maturity,representing an adult onset of obesity.We wished to evaluate the effect ofthe dietary exposure time and the age at which animals are exposed to a high-fat and high-sucrose(HFS) diet to determine whether these factors may result in disparate outcomes,as there is evidence suggesting that these factors result in differential metabolic disturbances.Based on dietary exposure time,we hypothesized that rats fed an HFS diet for 14 weeks from weaning(HFS Weanling) would demonstrate an increase in knee joint damage scores,whereas rats exposed to the HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult) and rats exposed to a standard chow diet(Chow)would not display an increase in knee joint damage scores.Methods:Male Sprague-Dawley rats were fed either an HFS diet for 14 weeks from weaning(HFS Weanling) or an HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult).At sacrifice,joints were scored using the modified Mankin Criteria,and serum was analyzed for a defined subset of inflammatory markers(Interleukin-6,leptin,monocyte chemoattractant protein-1,and tumor necrosis factorα).Results:When the HFS Weanling and HFS Adult groups were compared,both groups had a similar percent of body fat,although the HFS Weanling group had a significantly greater body mass than the HFS Adult group.The HFS Weanling and HFS Adult animals had a significant increase in body mass and percentage of body fat when compared to the Chow group.Although knee joint damage scores were low in all 3 groups,we found,contrary to our hypothesis,that the HFS Adult group had statistically significant greater knee joint damage scores than the Chow and HFS Weanling groups.Furthermore,we observed that the HFS Weanling group did not have significant differences in knee joint damage scores relative to the Chow group.Conclusion:These findings indicate that the HFS Weanling animals were better able to cope with the dietary challenge of an HFS diet than the HFS Adult group.Interestingly,when assessing various serum proinflammatory markers,no significant differences were detected between the HTS Adult and HFS Weanling groups.Although details regarding the mechanisms underlying an increase in knee joint damage scores in the HFS Adult group remain to be elucidated,these findings indicate that dietary exposure time maybe less important than the age at which an HFS diet is introduced.Moreover,increases in serum proinflammatory mediators do not appear to be directly linked to knee joint damage scores in the HFS Weanling group animals but may be partially responsible for the observed knee joint damage in the adults over the very short time of exposure to the HFS diet. 相似文献
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It has been several years since the concept of performance technology was introduced in the literature. This article describes how the Instructional Systems program at Florida State University has responded to the changes that are required to expand its orientation from instructional technology to performance technology. Gradual changes in several existing courses and the implementation of two new courses in performance systems analysis and electronic performance support systems are described. In the new courses, students interact with clients to determine needs, examine processes, design solutions, and determine returns on investments. Consideration is also given in the article to ways other universities might respond to the changes in the direction of the field. 相似文献
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Walter B. Pryzwansky 《Psychology in the schools》1981,18(4):460-466
Public Law 94-142, Education for All Handicapped Children Act, has had a dramatic impact on the schooling of exceptional children. Yet, rather limited attention has been directed to the one section of the law that mandates a particular decision-making approach for both the diagnosis and intervention tasks. The implications for the training and practice of applied psychologists who work with school-age children could be significant. This paper examines three areas of concern that impact the psychologist's role in working with exceptional children: (a) conditions that are considered crucial for the development of teams, (b) the literature regarding psychologists' input to school-based teams, and (c) reactions of school-based team members to such an approach. Related issues of importance to both trainers and practitioners in the field of psychology are then presented. 相似文献
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Eccentric exercise has been associated with an increase in serial sarcomere number in some studies,1 but not in others.2 Similarly,increasing excursion of muscles resulted in sarcomerogenesis in some studies using growing animals,3 but not in others using skeletally mature animals.4 However,chronic elongation and chronic shortening appears to be a strong regulator of sarcomere number increase5,6 and decrease,5,7 respectively,in animal models.Despite an abundance of research on the regulation of sarcomerogenesis under a variety of conditions,the mechanisms underlying in series sarcomere number adaptations in skeletal muscles remain a puzzle,especially in non-invasive human studies where measurements of sarcomerogenesis following interventions have not been possible to date. 相似文献
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Valdivia WD 《Minerva》2011,49(1):25-46
Evaluation studies of the Bayh-Dole Act are generally concerned with the pace of innovation or the transgressions to the independence
of research. While these concerns are important, I propose here to expand the range of public values considered in assessing
Bayh-Dole and formulating future reforms. To this end, I first examine the changes in the terms of the Bayh-Dole debate and
the drift in its design. Neoliberal ideas have had a definitive influence on U.S. innovation policy for the last thirty years,
including legislation to strengthen patent protection. Moreover, the neoliberal policy agenda is articulated and justified
in the interest of “competitiveness.” Rhetorically, this agenda equates competitiveness with economic growth and this with
the public interest. Against that backdrop, I use Public Value Failure criteria to show that values such as political equality,
transparency, and fairness in the distribution of the benefits of innovation, are worth considering to counter the “policy
drift” of Bayh-Dole. 相似文献
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