Lipids changes in liver cancer

Liver is one of the most important organs in energy metabolism. Most plasma apolipoproteins and endogenous lipids and lipoproteins are synthesized in the liver. It depends on the integrity of liver cellular function, which ensures homeostasis of lipid and lipoprotein metabolism. When liver cancer occurs, these processes are impaired and the plasma lipid and lipoprotein patterns may be changed. Liver cancer is the fifth common malignant tumor worldwide, and is closely related to the infections of hepatitis B virus （HBV） and hepatitis C virus （HCV）. HBV and HCV infections are quite common in China and other Southeast Asian countries. In addition, liver cancer is often followed by a procession of chronic hepatitis or cirrhosis, so that hepatic function is damaged obviously on these bases, which may significantly influence lipid and lipoprotein metabolism in vivo. In this review we summarize the clinical significance of lipid and lipoprotein metabolism under liver cancer.     

Novel distribution pattern of fibrinolytic components in rabbit tissues extract： a preliminary study

Objective: The purpose of this work was to investigate the distribution pattern of fibrinolytic factors and their inhibitors in rabbit tissues. Methods: The components of the fibrinolytic system in extracts from a variety of rabbit tissues, including tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), plasminogen (Plg), plasmin (Pl) and α2 plasmin inhibitor (α2PI), were determined by colorimetric assay. Results: The tissue extracts in renal, small intestine, lung, brain and spleen demonstrated strong fibrinolytic function, in which high activity of tPA, Plg and Pl was manifested; whereas in skeletal muscle, tongue and stomach, higher activity of PAI-1 and α2PI showed obviously. Also excellent linear correlations were found between levels of tPA and PAI-1, Pl and α2PI, Plg and Pl. In related tissues, renal cortex and renal marrow showed distinctly higher activity of tPA and lower activity of PAI-1, with the levels of Plg and Pl in renal cortex being higher than those in renal marrow, where the α2PI level was higher than that in renal cortex. Similarly, the levels of tPA, Plg and Pl in small intestine were higher than those in large intestine, but with respect to PAI-1 and α2PI, the matter was reverse. In addition, the fibrinolytic activity in muscle tissue was lower, however, the levels of tPA, Plg, and Pl in cardiac muscle were obviously higher than those in skeletal muscles, and the levels of PAI-1 and α2PI were significantly lower than those in skeletal muscle. Conclusion: Our data demonstrate that a remarkable difference of the fibrinolytic patterns exists in rabbit tissues, which has probable profound significance in understanding the relationship between the function of haemostasis or thrombosis and the physiologic function in tissues.     

CDIO理念在计算机硬件实践课程教学改革中的应用

以实例方式介绍了如何在CDIO工程教育理念的指导下对计算机硬件实践课程的教学目标、教学内容、教学方法、实践手段以及考核方式等方面进行设置、实施和运作的尝试过程,达到在教学改革中实现CDIO模式,进一步提升本科课程教学质量,提高学生综合素质的目的,以期为同类实践课程实施CDIO教学改革提供思路和借鉴.     

中南大学信息技术服务实践

我国大部分重点高校的信息化建设已经进入了数字化校园建设阶段,许多高校都在探索适合于本校的信息化建设之路。中南大学近几年以信息技术服务的思路推进信息化建设,在公共数据库平台上建设跨部门应用系统,取得了良好的信息化建设效果。该文结合中南大学信息化建设实践的具体成果,说明了信息技术服务的特点和优势,实践证明信息技术服务是建设数字化校园的有效途径。     

远程实验系统管理机制的研究与实现

以基于实验硬件设备的远程实验系统为对象,提出了一种适用于实验人数和实验设备数不匹配情况下关于实验权限分配的管理机制。在该管理机制下,远程实验系统由现场部分、管理机以及若干远程终端组成,以共享变量网络编程技术,实现系统中三方实验信息的互通。以传感器实验对该管理机制进行了测试,结果表明,多人同时参与远程实验时,远程实验者能获得相应实验权限,在实验人数大于实验平台数的情况下,远程实验系统能正常有序运行。     

分析化学省级精品课程建设模式探索

通过介绍分析化学课程的改革发展与具体实践,探讨了分析化学省级精品课程的建设模式,提出了分析化学省级精品课程的定位和目标,从课程的教学重点和难点中找出好的解决办法,同时提出了加强实践教学的设计思想,通过改进组织形式和指导方法,发展新的分析化学实验考核内容、实验成绩和综合训练考评方法,提高了教学效果和管理质量,使学生达到综合运用基本知识和发展实验技能的目的.     

地方高校心理学实验室建设的思考与实践

从地方高校的实际出发,提出心理学实验室建设的三项重要原则,详细介绍了韩山师范学院的心理学实验室建设情况,以期为地方高校心理学实验室的建设提供参考.     

基于产学研一体化的综合化学实验教学研究与实践

产学研一体化是根据企业发展需要,将实验教学与科学研究和成果转化相融合,达到培养学生能力和服务地方经济的目的.该文从能力培养层面分析了开设综合化学实验的必要性,提出了明确的综合化学实验教学改革目标和思路,并从教学内容、教学方法和运行机制等方面探讨了产学研一体化的综合化学实验教学改革对策.     

两种取向的教学论与有效教学研究

教学论可分为哲学取向与科学取向两个范畴,它们各有长处和短处。这两观种的取争向论的。教在学中论国的,随争着论新在课20改世实纪施9和0年对代课美改国成表效现的为反建思构,类主似义的教争学论观也与在科进学行取中向。教学将有效教学置于两种取向的教学理论中考察可发现,相对科学取向的教学观而言,属于哲学取向的建构主义教学观较少关心教学效率。教学的有效性研究本是科学取向教学论这根藤上结出的果。如今,在研究有效教学时,却期待不关心教学效率的建构主义教学观这棵树结出有效教学的果来。     

新课标下高中作文质量教学有效策略探析

信息社会,提高写作能力,已成为一种迫切的需要。以新课标为依据,学会多角度地观察生活、以真情实感为突破口、进一步提高＂综合运用多种表达方式＂的能力、培养学生的创造性思维、倡导学生＂有个性地表达、有创意地表达＂、在＂写作时代＂寻求动力和以提高教师的写作水平为抓手等有效策略,有助于提高高中学生的作文质量。