物理学家的思维方法系列谈(三)

每一科学原理的真理的界限都是相对的 ,它随着知识的增加时而扩张、时而缩小。———列宁8　划清真理的适用范围一条科学真理被揭示出来 ,它在多大范围内是适用的 ?起初往往弄不清楚。有时候 ,人们把它的适用范围划得很窄 ,经过一番扩大和推广 ,它才在广阔的领域里发挥作用。可     

数学大师吴文俊的科学成就

全面评价了当代著名数学家吴文俊先生的科学成就，并主要介绍了吴文俊在拓扑学、中国数学史与数学机械化方面的卓越贡献。     

满纸荒唐言谁知其中味--论新写实小说的悲剧意味

本文拟从压抑、扭曲、孤独、荒谬和异化这些精神困惑排斥人类最深层悲剧的理性认识,去体味并剖析新写实小说中小人物生命的失重与尴尬,以及掩藏在作者"零度情感"与"生命本相"叙述语境中的悲剧意味.     

论培养体育兴趣、形成锻炼习惯是学生终身体育教育的关键

培养学生从事体育活动的兴趣、养成体育锻炼的习惯，是体育教育成功的一个主要标志。忽视学生对体育的兴趣、爱好和习惯培养就不能莫定学生终身体育教育的基础。     

用改进的元胞自动化模型模拟不同信号灯控制策略下的交通流

Traffic flows controlled by traffic light strategies were investigated via a cellular automaton model with anticipation, which is suitable for describing urban traffic. Three kinds of strategies, i. e., synchronized, green-wave and random switching lights, were designed, simulated and compared with each other. It is shown that the green-wave strategy is only valid at lower density and there is not an effective way with the three strategies to improve the efficiency of traffic flow at high density.     

进一步规范和完善大学生就业服务体系

高校毕业生就业所面临的形势日趋严峻,已引起各级政府和各类高校的普遍重视,如何进一步规范和完善大学生就业服务体系具有重大的现实意义,通过加快高校就业信息网的建设,建立完善法律法规教育咨询服务体系,加强诚信教育等来进一步拓展大学生就业指导工作。     

西方视角下的东方神话——解读赛珍珠的《大地》

赛珍珠的《大地》是一个独特的文化现象。它是西方视角与中国精神的奇妙结合，作者采用了适度“神话”的方式来对待中国历史。同时，在小说艺术手法上，赛珍珠采用“奇迹”的写作方式和与生活真实适当疏离的方法营造一种传奇色彩，曲折地反映了作者的审美理想。这种写作态度集中体现在对主人公王龙三次婚姻生活的描写上。     

The relationship between parental bonding and peer victimization: examining child stress and hopelessness as mediators

The purpose of the current study was to investigate a two-stage model in which parent-related stress and hopelessness each served as mediators of the relationship between perceived parental bonding and South Korean adolescent peer victimization. This study also examined whether the mediating relationships differed by the gender of parents and adolescents. A casual chain with three links and four sets of variables were analyzed using structural equation modeling. Data were collected from 800 adolescents attending 10 middle schools in the Busan region of South Korea. Results indicated that both maternal and paternal parental bonding were negatively associated with stress, stress was positively associated with hopelessness, and hopelessness was positively associated with South Korean adolescent peer victimization. Most importantly, the significant negative associations between both maternal and paternal parental bonding and peer victimization were mediated by both stress and hopelessness. Furthermore, gender differences in these relationships existed for both parents and adolescents. Limitations and implications to practice were discussed.     

Kinesin KIF4A is associated with chemotherapeutic drug resistance by regulating intracellular trafficking of lung resistance-related protein

Multidrug resistance (MDR) is the major impediment to cancer chemotherapy. The expression of lung resistance-related protein (LRP), a non-ATP-binding cassette (ABC) transporter, is high in tumor cells, resulting in their resistance to a variety of cytotoxic drugs. However, the function of LRP in tumor drug resistance is not yet explicit. Our previous studies had shown that Kinesin KIF4A was overexpressed in cisplatin (DDP)-resistant human lung adenocarcinoma cells (A549/DDP cells) compared with A549 cells. The expression of KIF4A in A549 or A549/DDP cells significantly affects cisplatin resistance but the detailed mechanisms remain unclear. Here, we performed co-immunoprecipitation experiments to show that the tail domain of KIF4A interacted with the N-terminal of LRP. Immunofluorescence images showed that both the ability of binding to LRP and the motility of KIF4A were essential for the dispersed cytoplasm distribution of LRP. Altogether, our results shed light on a potential mechanism in that motor protein KIF4A promotes drug resistance of lung adenocarcinoma cells through transporting LRP-based vaults along microtubules towards the cell membrane. Thus KIF4A might be a cisplatin resistance-associated protein and serves as a potential target for chemotherapeutic drug resistance in lung cancer.     

谈谈投标的施工组织设计

通过对投标施工组织设计作用及特点的分析，阐述了投标施工组织设计在招投标过程中的重要性并指出了投标施工组织设计编制过程中一些经常易被忽视的重要问题。目的在于引导读者如何编制好投标施工组织设计文件。