Biochemical Profile of Nonalcoholic Fatty Liver Disease Patients in Eastern India with Histopathological Correlation

Aminotransferase assay is often used as a screening test as well as an endpoint for resolution of disease in nonalcoholic fatty liver disease (NAFLD). Aim of the study was to evaluate the relationship of transaminase level with metabolic variables and histology in NAFLD. Single center observational study was conducted in a gastroenterology clinic at Cuttack in coastal Odisha. Subjects were consecutive patients presenting with functional bowel disease and undergoing abdominal sonography. All participants were evaluated for the presence of metabolic syndrome (MS), insulin resistance, liver function test and lipid profile. Various parameters were compared between NAFLD subjects and controls. 53.5 % of NAFLD had normal serum transaminases, whereas 20.8 % of healthy controls had transaminitis. NAFLD patients had significantly higher BMI, fasting plasma glucose, serum transaminases, serum triglycerides, serum insulin and homeostatic model assessment (HOMA) IR than controls. NAFLD patients who had transaminitis had significantly higher incidence of MS and higher mean HOMA IR than those without. There was no significant difference in histopathological features between NAFLD with and without transaminitis. To conclude, over half of NAFLD subjects do not have transaminitis while transaminitis is present in a fifth of healthy people without fatty liver. Hence serum transaminase should not be used as screening test for NAFLD. NAFLD patients with transaminitis had a higher incidence of MS and insulin resistance than those without. However, there was no significant difference in histopathological features between these two groups.     

The enigma of cosmic rays-2

Part 1¹ of the article discussed the discovery and observed properties of cosmic ray particles. These energetic particles are produced during violent astronomical events. We discuss possible sources of cosmic rays detected on Earth in this article. Supernovae explosions of dying stars are believed to produce cosmic rays with low energy. The detection of ultra-high energy cosmic rays is however difficult to explain. On one hand, they must originate outside our Galaxy and on the other, the cosmic microwave background radiation pervading the universe makes it difficult for them to travel large distances in intergalactic space. So, they must be produced in the neighbourhood of our Galaxy, but are there enough energetic phenomena taking place in this region of the universe? Biman Nath is an astrophysicist at the Raman Research Institute, Bangalore.     

A programme for future audit professionals: using action research to nurture student engagement

Professionals require decision-making skills as well as technical knowledge. One might assume that their university education prepares them for this role yet, and least for future audit professionals, traditional text – and lecture – methods dominate teaching practice. This Participation Action Research study develops with auditing students a practice-informed, computer-based and judgement-orientated learning programme. We seek to identify ways in which student engagement in such decision-making dilemmas can be created and improved. Logs, student-surveys and notes from an independent observer document the longitudinal process. Findings identify features that improve student engagement and a contribution of the project is in revealing the value of removing technical and in-class social barriers. Implications for nurturing higher-level learning and for serving professional curriculums generally conclude the study.     

Calling orientations of junior doctors and medical interns in India: cultural,occupational and relational perspectives

This study examines the factors that shape calling orientations within the Indian context. Based on the narratives of 72 junior doctors and medical interns, it is found that participants identify with harbouring a calling both prior and subsequent to occupational entry. Although factors such as self-recognition of talent and sensemaking of work as destiny play a role, familial communication is found to be particularly influential in the formation of a calling outlook. A relational view of callings associated with generativity and family legacy is thus highlighted. The study additionally compares the career stories of individuals who do (n = 29) and those who do not (n = 43) frame their occupation as a calling. Participants with a calling orientation are found to have a strong affective attachment to the profession, further influenced by familial communication and value internalization. The findings also demonstrate that the calling experience is malleable and can evolve through work/life experiences.     

Antidiabetic and antioxidant effects of <Emphasis Type="Italic">Picrorhiza kurrooa</Emphasis> rhizome extracts in diabetic rats

Picrorhiza kurrooa is mentioned in Ayurveda for the treatment of many disorders, but it has not been subjected to systematic scientific investigations to assess its antidiabetic effect. The oral administration of aqueous and methanol extracts of P. kurrooa rhizomes (250 and 500 mg / kg body weight / day) for 15 days significantly reduced blood glucose, glycosylated haemoglobin and increased total hemoglobin, plasma insulin in alloxan-induced diabetes in albino rats. The treatment also showed significant correction in the level of nitric oxide radicals, superoxide radicals, peroxynitrite radical, lipid peroxidation, glutathione, glutathione reductase, glutathione-S-transferase, glutathione peroxidase, superoxide dismutase and catalase in the pancreas of alloxan diabetic rats.     

The role of pre-school education on learning achievement at primary level in Bangladesh

This paper examines the impact of pre-school education on learning achievement at primary level in Bangladesh. Evidence from learning achievement test and household and school-related data were obtained from 7093 pupils attending 440 primary schools in Bangladesh. Findings suggest that a small proportion (15.3%) of primary school pupils attended pre-school. Pupils from educated parents and well-off families were more likely to attend. In principle, however, attendance at pre-school did not predict later learning achievement at primary level, but a range of socio-demographic, school-related and additional educational factors did have an impact. It is concluded that further research is warranted to examine the quality of pre-school provision offered in Bangladesh and the qualifications of professionals working with young children in these centres.