高校图书馆数字资源的安全问题及管理策略

分析了数字资源的特点和当前威胁高校图书馆数字资源安全的隐患,并结合本校图书馆的做法,探讨了数字资源安全管理的策略。     

A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2

The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying asymptomatic and presymptomatic carriers of the virus, and thus highlights a strong motivation for diagnostics with high sensitivity that can be rapidly deployed. On the other hand, several concerning SARS-CoV-2 variants, including Omicron, are required to be identified as soon as the samples are identified as ‘positive’. Unfortunately, a traditional PCR test does not allow their specific identification. Herein, for the first time, we have developed MOPCS (Methodologies of Photonic CRISPR Sensing), which combines an optical sensing technology-surface plasmon resonance (SPR) with the ‘gene scissors’ clustered regularly interspaced short palindromic repeat (CRISPR) technique to achieve both high sensitivity and specificity when it comes to measurement of viral variants. MOPCS is a low-cost, CRISPR/Cas12a-system-empowered SPR gene-detecting platform that can analyze viral RNA, without the need for amplification, within 38 min from sample input to results output, and achieve a limit of detection of 15 fM. MOPCS achieves a highly sensitive analysis of SARS-CoV-2, and mutations appear in variants B.1.617.2 (Delta), B.1.1.529 (Omicron) and BA.1 (a subtype of Omicron). This platform was also used to analyze some recently collected patient samples from a local outbreak in China, identified by the Centers for Disease Control and Prevention. This innovative CRISPR-empowered SPR platform will further contribute to the fast, sensitive and accurate detection of target nucleic acid sequences with single-base mutations.     

培育时空观念素养的历史教学逻辑

将学科核心素养与学生的认知逻辑相结合,转化成切实的教学逻辑,培育学科核心素养才有可循路径。时空观念是高中历史学科五大核心素养之一,基于历史学科的特点和功能,可将时空观念素养概括为"知道时空事实""建立时空关联""建构时空解释""运用时空思维"四个层面。与学生的认知逻辑相结合,历史教学以创设教学情境促进学生感知时空特征,以教学问题的探究来建构时空关联,通过问题的拓展引导学生在不同时空框架下理解和解释史事,并在此过程中实现知识与素养的辩证促进,培育学生深层的时空思维,启迪学生生命的成长。     

区块链技术在网络舆情风险管理体系的应用研究

[目的/意义]挖掘弹性管理和区块链理论在网络舆情风险管理体系建设的应用价值,克服传统管理体系的技术弊端,突破现有网络舆情风险管理的难点和痛点,提高网络舆情风险管理效率。[方法/过程]基于网络舆情风险管理、弹性管理理论,确立网络舆情弹性风险管理的理论框架,进而应用区块链技术提出网络舆情风险管理系统体系,并对网络舆情风险识别和感知智慧分类账本、风险关联树以及智能合约进行详尽阐述。[结果/结论]构建的舆情风险管理系统、区块链数据保障系统体系,及应用区块链技术的网络舆情风险识别和感知智慧分类账本、风险关联树、智能合约,使得舆情风险管理数据更安全、数据可追溯、组织弹性适应性更强,能有效指引有关系统开发,并增强网络舆情风险管理可控性、提高网络舆情风险管理效率。     

合作素养:21世纪核心素养5C模型之五

合作是21世纪公民的必备素养,关注合作素养具有重要的现实意义。合作素养是一系列合作技能与态度的集合,涵盖愿景认同、责任分担与协商共进三个要素。愿景认同是基础,责任分担是关键,协商共进是保障。三要素相辅相成,有机融合。合作素养可以培养,如何结合中国语境,深入推进合作素养培养与评价是当前和今后的重要研究任务。     

大学课程设计自学指南:如何设计课程以促进意义深远的学习(续)

作为大学老师,为了达到好的教学效果,我们必须能够做好两项活动,既要做好课程设计,又要做好师生互动。就这两项活动而言,我们的课程设计能力常常是制约因素。《创造意义深远的学习经历:大学课程整合设计方案》一书作者,美国奥克拉荷马大学教学发展项目部主任迪.芬克博士撰写了一份大学课程设计的自学指南,旨在给大家介绍一套系统有效的课程设计程式,帮助大家学会怎样进行课程设计。指南包括课程整合设计的三个主要阶段,每阶段包括开篇的介绍性评价,读者可以加以使用的工作簿,以及读者在课程设计过程中可以对自己提出的一些问题,以对自己的设计实践进行推敲。     

High-entropy-alloy nanoparticles with 21 ultra-mixed elements for efficient photothermal conversionOA

Multi-metallic nanoparticles have been proven to be an efficient photothermal conversion material, for which the optical absorption can be broadened through the interband transitions(IBTs), but it remains a challenge due to the strong immiscibility among the repelling combinations. Here, assisted by an extremely high evaporation temperature, ultra-fast cooling and vapor-pressure strategy, the arc-discharged plasma method was employed to synthesize ultra-mixed multi-metallic nanoparticles compose...     

中小企业的技术创新策略——桑塔纳轿车国产化的启示

从桑塔纳轿车国产化的成功经验中得出：加盟到大企业的供应链中进行技术创新是众多零配件中小企业技术创新成功的重要原因;并通过对零配件中小企业四种技术创新模式的分析,总结出中小企业在技术创新过程中应结合本企业自身情况,选择适合企业实昧的技术创新模式,探索具有自己特色的技术创新之路。