Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

The present study aims to assess and compare the biochemical oxidative stress markers in male smokers and non-smokers with chronic periodontitis. One hundred thirty-four male chronic periodontitis patients and 64 apparently healthy male volunteers were recruited for the study. The periodontal status was evaluated by measuring gingival index, plaque index, papillary bleeding index and clinical attachment loss using UNC-15 probe. The biochemical markers estimated were total antioxidant capacity, RBC-superoxide dismutase, glutathione peroxidase, vitamin C, malondialdehyde and C-reactive protein. The obtained results indicate higher oxidative stress in chronic periodontitis. Smokers with chronic periodontitis show significantly higher periodontal clinical parameters and relatively higher systemic oxidative stress. Vitamin C estimation may be an important biochemical parameter in conjunction with clinical parameters for diagnosis of chronic periodontitis in smokers.     

Science teachers accelerated programme model: a joint partnership in the Pacific region

The paper heralds a new pedagogical model known as the Science Teachers Accelerated Programme as a platform to upgrade the qualifications of secondary school science teachers throughout the Pacific region. Based on a tripartite partnership between a higher education provider, a regional government and a cohort of science teachers, the model offers an accelerated Bachelor’s degree programme to the cohort. Using this tripartite partnership model, a pilot of the Science Teachers Accelerated Programme is underway between the University of the South Pacific, the Government of Samoa and a cohort of science teachers in Samoa. The underpinning activities garnering social and academic integration are highlighted with analytics. The strengths, challenges and opportunities of the new, cohort-taught science model are presented with relevant diagnoses, interventions and adaptive works carried out in the first half of the delivery plan. While the Government of Samoa is considering the implementation of a second cycle, the University of the South Pacific is considering extending the model to other regional countries.     

Biochemical Profile of Nonalcoholic Fatty Liver Disease Patients in Eastern India with Histopathological Correlation

Aminotransferase assay is often used as a screening test as well as an endpoint for resolution of disease in nonalcoholic fatty liver disease (NAFLD). Aim of the study was to evaluate the relationship of transaminase level with metabolic variables and histology in NAFLD. Single center observational study was conducted in a gastroenterology clinic at Cuttack in coastal Odisha. Subjects were consecutive patients presenting with functional bowel disease and undergoing abdominal sonography. All participants were evaluated for the presence of metabolic syndrome (MS), insulin resistance, liver function test and lipid profile. Various parameters were compared between NAFLD subjects and controls. 53.5 % of NAFLD had normal serum transaminases, whereas 20.8 % of healthy controls had transaminitis. NAFLD patients had significantly higher BMI, fasting plasma glucose, serum transaminases, serum triglycerides, serum insulin and homeostatic model assessment (HOMA) IR than controls. NAFLD patients who had transaminitis had significantly higher incidence of MS and higher mean HOMA IR than those without. There was no significant difference in histopathological features between NAFLD with and without transaminitis. To conclude, over half of NAFLD subjects do not have transaminitis while transaminitis is present in a fifth of healthy people without fatty liver. Hence serum transaminase should not be used as screening test for NAFLD. NAFLD patients with transaminitis had a higher incidence of MS and insulin resistance than those without. However, there was no significant difference in histopathological features between these two groups.     

Poly-Detect for Quantifying the Degree of Multidimensionality of Item Response Data

This study investigated the validity of the Poly-Detect procedure to determine the approximate simple dimensionality structure and to quantify the degree of multidimensionality present in polytomous data through simulation and real data analysis. Both unidimensional and two-dimensional data were generated in the simulation study for the complete and the BIB data. The simulation results showed that the dimensionality structures were similar between the corresponding complete data and the BIB data as identified by the Poly-Detect procedure. Also, the simulation results indicated that the number of response categories of items did not affect the performance of the Poly-Detect procedure in quantifying the degree of multidimensionality of polytomous data. Based on the simulation results, a subjective scale of the degree of multidimensionality of a data set was developed. Application of the Poly-Detect procedure on the 1992 NAEP eighth-grade reading data indicated that the degree of multidimensionality of the entire 1992 NAEP eighth-grade reading item pool was moderate at most.     

Assessing Dimensionality of a Set of Item Responses-Comparison of Different Approaches

This study compares the performance of three methodologies for assessing unidi-mensionality: DIMTEST, Holland and Rosenbaum's approach, and nonlinear factor analysis. Each method is examined and compared with other methods on simulated and real data sets. Seven data sets, all with 2,000 examinees, were generated: three unidimensional and four two-dimensional data sets. Two levels of correlation between abilities were considered:ρ= 3 and ρ= . 7. Eight different real data sets were used: Four of them were expected to be unidimensional, and the other four were expected to be two-dimensional. Findings suggest that all three methods correctly confirmed unidimensionality but differed in their ability to detect lack of unidimensionality. DIMTEST showed excellent power in detecting lack of unidimensionality; Holland and Rosenbaum's and nonlinear factor analysis approaches showed good power, provided the correlation between abilities was low.     

Notable and Emerging Variants of SARS-CoV-2 Virus: A Quick Glance

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiological agent of coronavirus disease-2019 (COVID-19), is a highly contagious pathogenic coronavirus to emerge and spread in human populations. Although substantial exertions have been laid to avert spread of COVID-19 by therapeutic and preventive countermeasures, but emergence of SARS-CoV-2 variants as a result of mutations make the infection more ominous. New viral confers a higher nasopharyngeal viral load, increased viral transmissibility, higher infectiousness, immune escape, increased resistance to monoclonal/polyclonal antibodies from convalescence sera/vaccine, and an enhanced virulence. Thus, it is pertinent to monitor evolving mutations and genetic diversity of SARS-CoV-2 as it is decisive for understanding the viral variants. In this review we provide an overview of colloquial nomenclature and the genetic characteristics of different SARS-CoV-2 variants in the context of mutational changes of the circulating strains, transmissibility potential, virulence and infectivity.     

Knowledge complementarity and knowledge exchange in supply channel relationships

Existing literature on knowledge exchange in inter-organizational relationships (e.g., a supply channel) reveals two opposing forces at work: (1) collaborative behavior and (2) opportunistic behavior. A concurrent assessment of the opposing perspectives and the contingencies under which each is relevant for supply channel performance can add valuable insights about the dynamics of knowledge exchange. We juxtapose the two behavior patterns using social capital theory and transaction cost economics (TCE) respectively as the explicators and employ knowledge complementarity as the contingency to reconcile the opposing behavior patterns. The choice of knowledge complementarity in this role stems from ample theoretical and empirical support in prior literature about the criticality of this factor in inter-firm knowledge exchange.     

Attachment and Temperament in the Early Life Course: A Meta‐Analytic Review

This meta‐analytic review examines the association between early attachment (assessed at 1–5 years) and child temperament (assessed at birth–12 years), and compares the strength of this association with recently documented meta‐analytic associations between early attachment and social competence, externalizing behavior, and internalizing symptoms. Based on 109 independent samples (N = 11,440) of diverse socioeconomic and ethnic backgrounds, temperament was weakly associated with attachment (in)security (d = .14, CI [0.08, 0.19]) but modestly associated with resistant attachment (d = .30, CI [0.21, 0.40]). Temperament was not significantly associated with avoidant (d = .10, CI [?0.02, 0.19]) or disorganized (d = .11, CI [?0.03, 0.25]) attachment. Across developmental domains, early attachment security was more strongly associated with social competence and externalizing behaviors than internalizing symptoms and temperament.