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51.
Roberto Assandri Silvia Accordino Ciro Canetta Elisabetta Buscarini Alessandro Scartabellati Chiara Tolassi Federico Serana 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2022,32(2)
IntroductionSeveral laboratory tests are characteristically altered in Coronavirus Disease 2019 (COVID-19), but are not totally accurate in predicting the disease outcome. The long pentraxin 3 (PTX3) is quickly released directly at inflammation sites by many immune cell types. Previous studies have shown that PTX3 correlated with disease severity in various inflammatory conditions. Our study investigated the use of PTX3 as a potential marker of COVID-19 severity and compared its performance in detecting a more severe form of the disease with that of routine laboratory parameters.Materials and methodsStored serum samples of RT-PCR confirmed COVID-19 cases that had been obtained at hospital admission were retrospectively analysed. Intensive care unit (ICU) stay was considered a surrogate endpoint of severe COVID-19. Pentraxin 3 was measured by a commercial enzyme-linked immunosorbent assay.ResultsA total of 96 patients were recruited from May 1st, 2020 to June 30th, 2020; 75/96 were transferred to ICU. Pentraxin 3 was higher in ICU vs non-ICU patients (35.86 vs 10.61 ng/mL, P < 0.001). Univariate and multivariate logistic regression models demonstrated that the only significant laboratory predictor of ICU stay was PTX3 (OR: 1.68 (1.19-2.29), P = 0.003), after controlling for comorbidities. The Receiver Operator Characteristic curve analysis showed that PTX3 had a higher accuracy compared to C-reactive protein (CRP), lactate dehydrogenase (LD), ferritin in identifying ICU patients (AUC of PTX3 = 0.98; CRP = 0.66; LD = 0.70; ferritin = 0.67, P < 0.001). A cut-off of PTX3 > 18 ng/mL yielded a sensitivity of 96% and a specificity of 100% in identifying patients requiring ICU.ConclusionHigh values of PTX3 predict a more severe COVID-19. 相似文献
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Roberto Carlos dos Santos Pacheco Vinícius Medina Kern Paulo Henrique S. Bermejo 《International Information and Library Review》2003,35(2-4):319
Cooperative organization has been proposed as a means to improve the usefulness of virtual libraries. Information interchange among library and other academic applications is often hindered by the lack of application interoperability. This hindrance may be overcome through the development of standards that allow for digital libraries to exchange and share information with other applications. The Graduate Program in Production Engineering (PPGEP) of the Federal University of Santa Catarina (UFSC) launched its Theses and Dissertations Bank (BTD) in 1995. BTD is possibly the first online academic digital library of theses. From a digital document repository, BTD evolved into a system that combines bibliometry and informetry features. BTD is used by students and faculty in their research activities, but also by decision makers from industry and academia. They use it, respectively, to search for specialists and to measure interest and knowledge interchange among PPGEP research areas. This article presents the history, features, and development prospects for the BTD project. The integration of BTD with other academic applications, especially those of the Brazilian national science and technology platform, is emphasized. 相似文献
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After years of neglect and an almost complete lack of maintenance, the Racconigi Royal Park was in an inevitable and widespread state of decay. This decay also involved the waterways that were designed in the nineteenth-century by Xavier Kurten (1811–1840). The seasonal lack of water and the agricultural needs of the farms around the Park made it necessary, during the planning stage of the restoration project, to consider the practicability and the effectiveness of some measures that were conceived to optimize the operation of the restored waterways, without altering the historical structure of the system. The realization of a hydraulic numerical model of the system, which is briefly illustrated in the first part of this case study, resulted to be the most suitable tool to study different possible solutions of the problem. The model simulations in fact helped the restorers put into effect the right remedies to favour the correct flow of the water, to make the whole historical system more efficient and to make its future maintenance easier. 相似文献
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The competence discourse issued by the Colombian Ministry of National Education defines an ontological duty, a set of logics for the education of subjectivity. Some interesting elements result from this analysis. The first level, or denotative level, manages a management or business cultural code. This code is closely related to the second level or connotative level linked to certain values translated, as Saussure says, into an ideology or myth: the myth of rational market in this case. This is the performing work of discourse, that language game that entails the promise of future success and happiness. 相似文献
57.
Fabio Augusto Barbieri Lilian Teresa Bucken Gobbi Paulo Roberto Pereira Santiago Sergio Augusto Cunha 《Journal of sports sciences》2015,33(13):1411-1419
The aim of this study was to analyse the characteristics of the asymmetries in the dominant and non-dominant limbs when kicking stationary and rolling balls. Ten experienced Brazilian amateur futsal players participated in this study. Each participant performed kicks under two conditions (stationary ball vs. rolling ball) with the dominant and non-dominant limbs (five kicks per condition per limb). We analysed the kicking accuracy, ball and foot velocities, angular joint displacement and velocity. The asymmetry between the dominant and non-dominant limbs was analysed by symmetry index and two-way repeated measures ANOVA. The results did not reveal any interaction between the condition and limb for ball velocity, foot velocity and accuracy. However, kicking with the dominant limb in both kicks showed higher ball velocity (stationary ball: dominant – 24.27 ± 2.21 m · s?1 and non-dominant – 21.62 ± 2.26 m · s?1; rolling ball: dominant – 23.88 ± 2.71 m · s?1 and non-dominant – 21.42 ± 2.25 m · s?1), foot velocity (stationary ball: dominant – 17.61 ± 1.87 m · s?1 and non-dominant – 15.58 ± 2.69 m · s?1; rolling ball: dominant – 17.25 ± 2.26 m · s?1 and non-dominant – 14.77 ± 2.35 m · s?1) and accuracy (stationary ball: dominant – 1.17 ± 0.84 m and non-dominant – 1.56 ± 1.30 m; rolling ball: dominant – 1.31 ± 0.91 m and non-dominant – 1.97 ± 1.44 m). In addition, the angular joint adjustments were dependent on the limb in both kicks (the kicks with non-dominant limb showed lower hip external rotation than the kicks with the dominant limb), indicating that the hip joint is important in kick performance. In conclusion, the kicks with the non-dominant limb showed different angular adjustments in comparison to kicks with the dominant limb. In addition, kicking a rolling ball with the non-dominant limb showed higher asymmetry for accuracy, indicating that complex kicks are more asymmetric. 相似文献
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Leticia I. RAMíREZ-CAVAZOS Charles JUNGHANNS Rakesh NAIR Diana L. CáRDENAS-CHáVEZ Carlos HERNáNDEZ-LUNA Spiros N. AGATHOS Roberto PARRA 《Journal of Zhejiang University. Science. B》2014,15(4):343-352
研究目的:优化获得血红密孔菌(P.sanguineus)的最佳培养基组成,提高耐热漆酶的产量。创新要点:获得了目前文献报道的最高水平的漆酶活力。研究方法:通过单因素试验研究了不同培养基(番茄汁、麦麸、麦芽提取物和葡萄糖细菌蛋白胨培养基)和不同组合诱导剂(大豆油、阿魏酸、没食子酸、二甲基苯胺、酸性蓝62和活性蓝19分别与硫酸铜组合诱导剂)对P.sanguineus产耐热漆酶的影响。在此基础上采用中心组合试验设计,进一步研究了番茄汁培养基结合硫酸铜和大豆油组合诱导剂对P.sanguineus产耐热漆酶的影响。利用SAS10.0和响应面分析方法对试验结果进行了统计分析和建立回归模型。重要结论:通过中心组合设计优化得出P.sanguineus产耐热漆酶的最优培养基条件:以36.8%番茄汁为培养基,以3 mmol/L硫酸铜和1%大豆油作为组合诱导剂。该条件下在10 L搅拌槽生物反应器中漆酶活力达到了143 000 IU/L(2,2'-联氮双(3-乙基苯并噻唑啉-6-磺酸)为底物,pH值为3.0)。 相似文献
60.
Immigration is a hotly debated and politicized policy area, one in which governments confront fierce opposition from populist parties and negative media narratives altering citizens’ perceptions of the issue. There is also growing scholarly interest in migration; new migrant integration research advocates for a conceptual shift away from focusing on migrant populations and towards rethinking host communities. At the same time, public sector innovation research is developing new approaches for how governments and public organizations can be innovative in dealing with grand challenges such as migration. The aim of this article is to merge these two subfields in order to answer a guiding research question: how can public organizations be innovative to promote integration for migrants? We suggest a typology of different innovation strategies that governments can adopt regarding integration, and we present five illustrative cases from European nations to examine how governments can innovate in order to integrate migrants. We find that governments can use multiple tools to promote integration and respond to grand challenges; governments can use various sources of innovation to address major barriers to migrant integration (e.g. language barriers, negative media and public opinion, and the difficulties of providing concrete assistance). 相似文献