Intermittent hypoxia exposure in a hypobaric chamber and erythropoietin abuse interpretation

The aim of this study was to assess the effect of intermittent hypoxia exposure on direct and indirect methods used to evaluate recombinant human erythropoietin (rhEPO) misuse. Sixteen male triathletes were randomly assigned to either the intermittent hypoxia exposure group (experimental group) or the control normoxic group (control group). The members of the experimental group were exposed to simulated altitude (from 4000 to 5500 m) in a hypobaric chamber for 3 h per day, 5 days a week, for 4 weeks. Blood and urine samples were collected before and after the first and the final exposures, and again 2 weeks after the final exposure. While serum EPO significantly increased after the first [from a mean 8.3 IU x l(-1) (s = 3.2) to 16.6 IU x l(-1) (s = 4.7)] and final exposures [from 4.6 IU x l(-1) (s = 1.4) to 24.8 IU x l(-1) (s = 9.3)], haemoglobin, percentage of reticulocytes, and soluble transferrin receptor were not elevated. Second-generation ON/OFF models (indirect rhEPO misuse detection) were insensitive to intermittent hypoxia exposure. The distribution of the urinary EPO isoelectric profiles (direct rhEPO misuse detection) was altered after intermittent hypoxia exposure with a slight shift towards more basic isoforms. However, those shifts never resulted in misinterpretation of results. The intermittent hypoxia exposure protocol studied did not produce any false-positive result for indirect or direct detection of rhEPO misuse in spite of the changes in EPO serum concentrations and urinary EPO isoelectric profiles, respectively.     

Activity profile of top-class association football referees in relation to performance in selected physical tests

The aims of the present study were (1) to analyse the physical demands of top-class referees and (2) to compare their official FIFA fitness test results with physical performance during a match. The work rate profiles of 11 international referees were assessed during 12 competitive matches at the 2003 FIFA Under-17 World Cup and then analysed using a bi-dimensional photogrammetric video analysis system based on direct lineal transformation (DLT) algorithms. In the first 15 min of matches, the referees were more active, performing more high-intensity exercise (P < 0.01) than in the first 15 min of the second half. During the second half of matches, the referees covered a shorter distance (P < 0.01), spent more time standing still (P < 0.05), and covered less ground cruising (P < 0.05), sprinting (P < 0.05), and moving backwards (P < 0.001) than in the first half. Also in the second 45 min, the distance of referees from infringements increased (P < 0.05) in the left attacking zone of the filed. There was also a decrease (P < 0.05) in performance in the period following the most high-intensity activity, compared with the mean for the 90 min. Time spent performing high-intensity activities during a match was not related to performance in the 12-min run (r(2) = 0.30; P < 0.05), the 200-m sprint (r(2) = 0.05; P < 0.05), or the 50-m sprint (r(2) = 0.001; P < 0.05). The results of this study show that: (1) top-class referees experienced fatigue at different stages of the match, and (2) the typical field tests used by FIFA (two 50-m and 200-m sprints, followed by a 12-min run) are not correlated with match activities.     

Modulation of general and specific cognitive precursors to early mathematical competencies in preschool children

European Journal of Psychology of Education - The main goal of this study was to analyze the contribution of predictors of both domain-general (working memory, processing speed, and receptive...     

Criminal justice education in relation to law school expectation: A failure of confidence

This paper discusses the findings from a survey of admissions officers at law schools in the United States. Deans of Admission (N=119) were asked a variety of questions pertaining to how the undergraduate criminal justice major is perceived in relation to the adequacy of the academic preparation it provides for individuals applying and/or currently attending law school. The findings suggest that the criminal justice major is not perceived as adequate preparation for law school education by the Deans of Admission. Results are discussed within the context of the criminal justice curricula standards recommended by the academic review committee of the Academy of Criminal Justice Sciences.     

Through Student Eyes: Perceptions and Aspirations of Students from the Armenian State Agrarian University and Selected European Universities

Abstract

This research compared attributes of students enrolled in the Armenian State Agrarian University (ASAU) with university students from 30 European countries (EFMD) about graduate study policy issues. A cross-national comparative design used a survey questionnaire to explore contextual, social and cultural phenomena. Samples included 801 ASAU and 3,265 EFMD students. Demographics of samples were similar. Students were largely unaware of the Bologna reforms and the impact on study abroad. Slightly more than half of EFMD participants were in a bachelor's programme compared to 96% of ASAU students. ASAU students held a more pragmatic rationale for foreign study, ranking ‘advancing professional careers’ as the top reason, while EFMD students chose ‘overall experience’. Obstacles included bureaucracy, funding and accommodations. Although groups had similar geographical preferences for foreign study, Eastern Europe was more preferred by ASAU students. Half of the EFMD students planned graduate enrollment ‘immediately following the degree’ compared to one-quarter of ASAU students. Half of the EFMD students were aware of mobility scholarships compared to three-quarters of ASAU students. One in two EFMD students reported university media rankings important compared to one in seven ASAU students.

The Bologna Declaration accelerated horizontal collaboration among European universities. Students have a larger collective voice in curriculum change. The findings of this research provide a better understanding of student aspirations, motivations, expectations and barriers. These findings can contribute to guiding policies and procedures for recruitment, admission, retention and mobility.     

Changing the teaching/learning procedures in physics for agricultural engineering. A case study

The subject ‘Physical Fundamentals of Engineering’ for agricultural engineers in the University of Extremadura has long had high rates of students not attending classes, not presenting for examinations and, finally, failing the subject. During the 2007 and 2008 courses, the teaching/learning procedures were strongly modified. Analysis of the proportion of students taking final examinations and of the final marks shows that the new procedure leads to a satisfactory progress in most of the objectives, including a general improvement in their marks and pass rates. In particular, it was found that the new procedure needs to be maintained by the teachers for at least two courses for the greatest success.     

Evolutionary Maps: A new model for the analysis of conceptual development,with application to the diurnal cycle

This paper presents a model of how children generate concrete concepts from perception through processes of differentiation and integration. The model informs the design of a novel methodology (evolutionary maps or emaps), whose implementation on certain domains unfolds the web of itineraries that children may follow in the construction of concrete conceptual knowledge and pinpoints, for each conception, the architecture of the conceptual change that leads to the scientific concept. Remarkably, the generative character of its syntax yields conceptions that, if unknown, amount to predictions that can be tested experimentally. Its application to the diurnal cycle (including the sun's trajectory in the sky) indicates that the model is correct and the methodology works (in some domains). Specifically, said emap predicts a number of exotic trajectories of the sun in the sky that, in the experimental work, were drawn spontaneously both on paper and a dome. Additionally, the application of the emaps theoretical framework in clinical interviews has provided new insight into other cognitive processes. The field of validity of the methodology and its possible applications to science education are discussed.     

Effect of custom-made and prefabricated insoles on plantar loading parameters during running with and without fatigue

Abstract

Controversy exists whether custom-made insoles are more effective in reducing plantar loading compared to prefabricated insoles. Forty recreational athletes ran using custom-made, prefabricated, and the original insoles of their running shoes, at rest and after a fatigue run. Contact time, stride rate, and plantar loading parameters were measured. Neither the insole conditions nor the fatigue state modified contact time and stride rate. Addressing prevention of running injuries, post-fatigue loading values are of great interest. Custom-made insoles reduced the post-fatigue loading under the hallux (92 vs. 130 kPa, P < 0.05), medial midfoot (70 vs. 105 kPa, P < 0.01), and lateral midfoot (62 vs 96 kPa, P < 0.01). Prefabricated insoles provoked reductions in post-fatigue loading under the toes (120 vs. 175 kPa, P < 0.05), medial midfoot (71 vs. 105 kPa, P < 0.01), and lateral midfoot (68 vs. 96 kPa, P < 0.01). Regarding both study insoles, custom-made insoles reduced by 31% and 54% plantar loading under the medial and lateral heel compared to the prefabricated insoles. Finally, fatigue state did not influence plantar loading regardless the insole condition. In long-distance races, even a slight reduction in plantar loading at each foot strike may suppose a significant decrease in the overall stress experienced by the foot, and therefore the use of insoles may be an important protective mechanism for plantar overloading.     

Identification of histological threshold concepts in health sciences curricula: Students' perception

Students' metacognitive skills and perceptions are considered important variables for high-quality learning. In this study, students' perceptions were used to identify histological threshold concepts (integrative, irreversible, transformative, and troublesome) in three health sciences curricula. A specific questionnaire was developed and validated to characterize students' perceptions of histological threshold concepts. A sample of 410 undergraduate students enrolled in the dentistry, medicine, and pharmacy degree programs participated in the study. Concepts assessed in the study were clustered to ten categories (factors) by exploratory and confirmatory factor analysis. Concepts linked to tissue organization and tissue functional states received the highest scores from students in all degree programs, suggesting that the process of learning histology requires the integration of both static concepts related to the constituent elements of tissues and dynamic concepts such as stem cells as a tissue renewal substrate, or the euplasic, proplasic and retroplasic states of tissues. The complexity of integrating static and dynamic concepts may pose a challenging barrier to the comprehension of histology. In addition, several differences were detected among the students in different degree programs. Dentistry students more often perceived morphostructural concepts as threshold concepts, whereas medical students highlighted concepts related to two-dimensional microscopic identification. Lastly, pharmacy students identified concepts related to tissue general activity as critical for the comprehension and learning of histology. The identification of threshold concepts through students' perceptions is potentially useful to improve the teaching and learning process in health sciences curricula.     

A Mirage of Change: Visibility of Politicians on TVE during the 2015 and 2016 General Elections

ABSTRACT

The use of strategies to enhance the media visibility of politicians intensifies above all at election time and their focus is chiefly television due to the fact that it still has the greatest power to sway voters. Thus, based on a content analysis of the evening news on Televisión Española (TVE) and 18 semi-structured in-depth interviews with professionals working at the Spanish public broadcaster, the airtime that politicians were given was established to assess whether it had fulfilled its obligation as regards independence and pluralism at two crucial moments for Spanish politics: the period prior to the election calls, the pre-campaign periods and the official campaigns before the general elections held on 20 December 2015 and 26 June 2016. Both were unique in their own way: on the one hand, the debut of new political parties with the potential to win a large number of seats in Parliament; and, on the other, despite the fact that in just six months the party in power had lost its absolute majority and there were still no visible signs of change at TVE, it is still worth examining the variations in news treatment prior to both elections.