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991.
Simmons DC Kame'enui EJ Harn B Coyne MD Stoolmiller M Santoro LE Smith SB Beck CT Kaufman NK 《Journal of learning disabilities》2007,40(4):331-347
A randomized experimental design with three levels of intervention was used to compare the effects of beginning reading interventions on early phonemic, decoding, and spelling outcomes of 96 kindergartners identified as at risk for reading difficulty. The three instructional interventions varied systematically along two dimensions--time and design of instruction specificity--and consisted of (a) 30 min with high design specificity (30/H), (b) 15 min with high design specificity plus 15 min of non-code-based instruction (15/H+15), and (c) a commercial comparison condition that reflected 30 min of moderate design specificity instruction (30/M). With the exception of the second 15 min of the 15/H+15 condition, all instruction focused on phonemic, alphabetic, and orthographic skills and strategies. Students were randomly assigned to one of the three interventions and received 108 thirty-minute sessions of small-group instruction as a supplement to their typical half-day kindergarten experience. Planned comparisons indicated findings of statistical and practical significance that varied according to measure and students' entry-level performance. The results are discussed in terms of the pedagogical precision needed to design and provide effective and efficient instruction for students who are most at risk. 相似文献
992.
Balachandar V Lakshman Kumar B Sasikala K Manikantan P Sangeetha R Mohana Devi S 《Journal of Zhejiang University. Science. B》2007,8(9):638-646
The aim of the present investigation was to study the major chromosomal aberrations （CA） like deletion, translocation, inversion and mosaic in prostate cancer patients of Tamilnadu, Southern India. Totally 45 blood samples were collected from various hospitals in Tamilnadu, Southern India. Equal numbers of normal healthy subjects were chosen after signing a consent form. Volunteers provided blood samples （5 ml） to establish leukocyte cultures. Cytogenetic studies were performed by using Giemsaanding technique and finally the results were ensured by spectral karyotyping （SKY） technique. In the present investigation, major CA like deletion, translocation, inversion and mosaic were identifed in experimental subjects. Results showed frequent CA in chromosomes 1, 3, 5, 6, 7, 9, 13, 16, 18 and X. In comparison with experimental subjects, the control subjects exhibited very low levels of major CA （P〈0.05）. In the present study, the high frequency of centromeric rearrangements indicates a potential role for mitotic irregularities associated with the centromere in prostate cancer tumorigenesis. Identification of chromosome alterations may be helpful in understanding the molecular basis of the disease in better manner. 相似文献
993.
994.
可贵的激情——高尚的情操 总被引：1，自引：0，他引：1
在我们学校里有一个很好的少先队员的组织——少年保护大自然委员会。这个组织开展活动以来已经有好几年了。孩子们经常以少先队小队或班级为单位到田野、森林、草原和池边去,警惕地观察是否有人动手伤害“绿色的朋友”,是否出现了危害树木和花草的害虫,是否有人蓄意潜入杂草丛生的岸边,乘鱼产卵的时侯偷偷地来钓鱼,是否在远方某处响起了猎人的枪声,是否有云雀或野鸭的鲜 相似文献
995.
Seifer R LaGasse LL Lester B Bauer CR Shankaran S Bada HS Wright LL Smeriglio VL Liu J 《Child development》2004,75(3):850-868
Attachment status of children exposed in utero to cocaine, opiates, and other substances was examined at 18 months (n=860) and 36 months (n=732) corrected age. Children exposed to cocaine and opiates had slightly lower rates of attachment security (but not disorganization), and their insecurity was skewed toward ambivalent, rather than avoidant, strategies. Continued postnatal alcohol use was associated with higher rates of insecurity and disorganization at 18, but not 36, months of age. Stability of attachment across the 18-month period was barely above chance expectation. Attachment status at 18 months was associated with child temperament and caregiver-child interaction; at 36 months, attachment was associated with child temperament, child behavior problems, and caregivers' parenting self-esteem. 相似文献
996.
This study investigated the use of a word processor for enhancing the academic outcomes of three students with writing disabilities in a junior high school. A single-subject ABAB design was used to compare academic output produced during class time with and without a computer equipped with a word processor. The number of spelling errors, the number of reading errors, and the number of words used per text were counted, and the overall structure and organization of text were examined across all in-class materials. The data demonstrated a clear difference between handwritten and computer phases. In traditional paper-and-pencil phases, students produced outcomes that had more spelling mistakes, more reading errors, and lower overall quality of organization and structure in comparison with the phases in which a computer equipped with a word processor was used. The results did not indicate any noticeable difference in the number of words per text. Implications and future research directions are discussed. 相似文献
997.
998.
晚饭后,我正在收拾餐桌,7岁的女儿突然问我：“妈妈,你可不可以给我买个花盆？”“花盆？噢,亲爱的,妈妈不会种花,而且妈妈也没时间照顾花。如果你想要什么花,妈妈可以给你买,直接插在花瓶里。”想起每天一大堆待洗的衣服、待收拾的杯盘碗碟、待做的室内清洁、待写的稿件…一我整个神经都绷得紧紧的, 相似文献
999.
Ruszkowska B Sokup A Kulwas A Socha MW Góralczyk K Góralczyk B Rość D 《Journal of Zhejiang University. Science. B》2012,13(1):35-42
Objective
In postmenopausal women, an increased leptin concentration and reduced levels of ghrelin and adiponectin were observed. The aim of this study was to evaluate the concentrations of the active form of ghrelin, total ghrelin, leptin receptor, lipoprotein(a) (Lp(a)), and plasminogen activator inhibitor type 1 (PAI-1) in postmenopausal women who received oral or transdermal menopausal hormonal therapy (MHT). 相似文献1000.