Biomarkers of inflammation and cardiac remodeling: the quest of relevant companions for the risk stratification of heart failure patients is still ongoing

Heart failure (HF) is a frequent chronic disease in elderly people and represents a major health and economic burden. The accurate diagnosis of HF and the identification of high risk patients is mandatory to select the appropriate therapy and care. HF is associated to cardiac remodeling and inflammation and to the release of neurohormones. If natriuretic peptides remain the biomarkers of choice for the diagnosis and the prognosis of HF, several biomarkers related to cardiac remodeling and inflammation are available for testing and may add valuable information for the risk estimation of HF patients and for the selection of the most appropriated therapy. Furthermore, the quest for new efficient biomarkers of cardiac remodeling and inflammation is still ongoing and new candidates have been identified for a potential use in daily clinical practices. However, before their potential translation to routine parameters several challenges ranging form the analytical validation to the cost-effectiveness estimation should be considered.     

如何培养学生在数学教学中的解题能力

中学数学教学的目的,归根结底在于培养学生的解题能力,提高数学解题能力是数学教学中一项十分重要的任务。提高学生解题能力始终贯穿于教学始终,我们必须把它放在十分重要的位置。教学关键是教会学生用所学的知识解决实际问题,即要提高学生的解题能力。文章从培养学生“数形”整合、“方程”思维、“对应”思维、“转化”能力、增强自信等五个方面谈如何培养学生的数学解题能力。那么,如何才能提高学生的解题能力,具体方法上讲主要可以从以下几方面入手：     

有关学生数学应用能力培养的重要性和基本途径

针对如何培养学生的数学应用意识,提高学生应用数学知识解决问题的能力进行了分析。     

试析水泵的节能性与安全性

在水处理中,水泵是极其重要的机器设备,它的正常和高效运行对整个水处理过程起着决定性的作用。但由于一般的污水处理中,水泵都处于高压高腐蚀性等环境,因此,它的安全使用技术是非常重要的。此外,水泵属于一种高能耗设备,在使用过程中的节能问题又是一个关键。本文就将重点探讨水泵在水处理中应该注意的节能性和安全性这两方面的技术问题。     

浅谈新技术在冷却塔系统中的运用

工业生产或冷却工艺过程中产生的废热,一般要用冷却水来导走。冷却塔的作用是将挟带废热的冷却水在塔内与空气进行热交换,使废热传输给空气并散人大气。结合实际,重点介绍了新技术在冷却塔系统中的运用。     

Shrink-film microfluidic education modules: Complete devices within minutes

As advances in microfluidics continue to make contributions to diagnostics and life sciences, broader awareness of this expanding field becomes necessary. By leveraging low-cost microfabrication techniques that require no capital equipment or infrastructure, simple, accessible, and effective educational modules can be made available for a broad range of educational needs from middle school demonstrations to college laboratory classes. These modules demonstrate key microfluidic concepts such as diffusion and separation as well as "laboratory on-chip" applications including chemical reactions and biological assays. These modules are intended to provide an interdisciplinary hands-on experience, including chip design, fabrication of functional devices, and experiments at the microscale. Consequently, students will be able to conceptualize physics at small scales, gain experience in computer-aided design and microfabrication, and perform experiments-all in the context of addressing real-world challenges by making their own lab-on-chip devices.     

Disposable parallel poly(dimethylsiloxane) microbioreactor with integrated readout grid for germination screening of Aspergillus ochraceus

In this work a disposable, parallel microbioreactor (MBR) suitable for screening in batch or continuous mode is presented. The reactor consists of five parallel microchambers made of poly(dimethylsiloxane) bonded to a glass substrate. A grid structure is engraved on each chamber, allowing subsequent morphology imaging. Measurements are recorded over the entire cultivation period with constant parameters, namely, position and focus in the z-axis. The microdevice may be used for either parallel, uni- or multiparametric screening, and overcomes the drawback of gridless microwell plates which require expensive equipment such as an inverted microscope with an automatic stage. To validate the scalability from laboratory scale to microscale, and thus the cultivation protocol in the MBR, the germination of fungal spores (A. ochraceus) is evaluated for two different key magnitudes (pH and temperature) and compared to the results obtained from conventional laboratory scale systems (flasks and agar plates). Information on germination capacity with regard to interspecies' variability allows for optimization of industrial processes as optimal pH and temperature matched to the mesoscopic cultivation systems. The germination conditions therefore remain unaffected inside the MBR, while providing the following advantages: (i) dramatic reduction of medium consumption, (ii) submerged cultivation with constant oxygen supply, (iii) assured low cost and disposability, and (iv) possibility of a continuous cultivation mode.     

Development and initial validation of the Psychological Characteristics of Developing Excellence Questionnaire

The development of talent is a complex process mediated by a host of psychological, social, physical, and environmental variables. Unfortunately, the multiple processes involved in talent development are frequently ignored by the systems and protocols employed in sport. Modern approaches to talent development are beginning to stress the initial possession, then subsequent development, of generic psychological characteristics (e.g. psychological characteristics of developing excellence; MacNamara, Button, & Collins, 2010a , 2010b ) as the best way to realize latent potential. Accordingly, this paper describes the development and initial validation of the Psychological Characteristics of Developing Excellence Questionnaire (PCDEQ). In the first phase, an initial list of 160 items was developed. A combination of expert panel reviews, cognitive interviews, and a pilot test was used to assess the relevance, representativeness, and validity of each item. Ninety-six items were retained following these steps. Exploratory factor analysis, with a sample of 363 athletes, revealed an interpretable 59-item, 6-factor solution with good internal consistency (0.870, 0.866, 0.847, 0.741, 0.749, and 0.701 respectively). The Psychological Characteristics of Developing Excellence Questionnaire would appear to hold promise as a useful tool to provide coaches and athletes with information about the psychological characteristics of developing excellence that are being properly addressed or neglected during different stages of development or in different contexts.     

Participation-related relative age effects in Masters swimming: a 6-year retrospective longitudinal analysis

Medic and colleagues (Medic, Starkes, & Young, 2007) found that relatively younger cohorts of Masters athletes had higher participation rates and achieved higher performances compared with a relatively older cohort. Considering that Medic and colleagues' (2007) study was cross-sectional in nature, the purpose of this investigation was to employ a retrospective longitudinal study design to examine the participation rates of Masters swimmers as a function of an individual's constituent year within any 5-year age category over a period of 6 years. Using archived data from the 2003 to 2009 US Masters Short Course National Championships, swimmers' attendance was followed for a period of six consecutive years. Results indicated that a participation-related relative age effect was observed among swimmers who, over a period of 6 years, competed in either at least one championship (N = 2596; Cochran's Q? = 64.16, r(s) = -0.92, both P < 0.0001) or at least three championships (N = 441; Cochran's Q? = 47.51, r(s) = -0.91, both P < 0.0001). Overall, effect size analyses indicated that the odds of a Masters swimmer participating in the championship during the first constituent year of any 5-year age category was more than two times greater than the odds of that athlete participating during the fifth constituent year.     

The effect of a supported exercise programme in patients with newly diagnosed Type 2 diabetes: a pilot study

The aim of this study was to examine the effectiveness of either a standard care programme (n = 9) or a 12-week supported exercise programme (n = 10) on glycaemic control, β-cell responsiveness, insulin resistance, and lipid profiles in newly diagnosed Type 2 diabetes patients. The standard care programme consisted of advice to exercise at moderate to high intensity for 30 min five times a week; the supported exercise programme consisted of three 60-min supported plus two unsupported exercise sessions per week. Between-group analyses demonstrated a difference for changes in low-density lipoprotein cholesterol only (standard care programme 0.01 mmol · L(-1), supported exercise programme -0.6 mmol · L(-1); P = 0.04). Following the standard care programme, within-group analyses demonstrated a significant reduction in waist circumference, whereas following the supported exercise programme there were reductions in glycosylated haemoglobin (6.4 vs. 6.0%; P = 0.007), waist circumference (101.4 vs. 97.2 cm; P = 0.021), body mass (91.7 vs. 87.9 kg; P = 0.007), body mass index (30.0 vs. 28.7 kg · m(-2); P = 0.006), total cholesterol (5.3 vs. 4.6 mmol · L(-1); P = 0.046), low-density lipoprotein cholesterol (3.2 vs. 2.6 mmol · L(-1); P = 0.028), fasting β-cell responsiveness (11.5 × 10(-9) vs. 7.0 × 10(-9) pmol · kg(-1) · min(-1); P = 0.009), and insulin resistance (3.0 vs. 2.1; P = 0.049). The supported exercise programme improved glycaemic control through enhanced β-cell function associated with decreased insulin resistance and improved lipid profile. This research highlights the need for research into unsupported and supported exercise programmes to establish more comprehensive lifestyle advice for Type 2 diabetes patients.