Searching ClinicalTrials.gov and the International Clinical Trials Registry Platform to inform systematic reviews: what are the optimal search approaches?

Background:

Since 2005, International Committee of Medical Journal Editors (ICMJE) member journals have required that clinical trials be registered in publicly available trials registers before they are considered for publication.

Objectives:

The research explores whether it is adequate, when searching to inform systematic reviews, to search for relevant clinical trials using only public trials registers and to identify the optimal search approaches in trials registers.

Methods:

A search was conducted in ClinicalTrials.gov and the International Clinical Trials Registry Platform (ICTRP) for research studies that had been included in eight systematic reviews. Four search approaches (highly sensitive, sensitive, precise, and highly precise) were performed using the basic and advanced interfaces in both resources.

Results:

On average, 84% of studies were not listed in either resource. The largest number of included studies was retrieved in ClinicalTrials.gov and ICTRP when a sensitive search approach was used in the basic interface. The use of the advanced interface maintained or improved sensitivity in 16 of 19 strategies for Clinicaltrials.gov and 8 of 18 for ICTRP. No single search approach was sensitive enough to identify all studies included in the 6 reviews.

Conclusions:

Trials registers cannot yet be relied upon as the sole means to locate trials for systematic reviews. Trials registers lag behind the major bibliographic databases in terms of their search interfaces.

Implications:

For systematic reviews, trials registers and major bibliographic databases should be searched. Trials registers should be searched using sensitive approaches, and both the registers consulted in this study should be searched.Clinical trials registers such as ClinicalTrials.gov and portals to trials registers such as the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) are increasingly used to identify ongoing or completed clinical trials. These resources offer important information on the methods and progress of trials likely to be of interest to a range of users, including researchers, clinicians, and patients. The extent to which these resources can be relied upon as a sole source of trials for inclusion in systematic reviews, including Cochrane systematic reviews (CSRs), is the subject of the research study reported here. This study also investigates the most efficient ways that librarians, information professionals, and other searchers can search these resources. Search efficiency was investigated by evaluating the overlap and unique yield of searches in the two resources and by testing four search approaches. The tested search approaches ranged from the very precise (single specific condition search term combined with a single specific intervention search term) to the very sensitive (at least two interventions terms).     

Shared Education in contested spaces: How collaborative networks improve communities and schools

Societies which suffer from ethnic and political divisions are often characterised by patterns of social and institutional separation, and sometimes these divisions remain even after political conflict has ended. This has occurred in Northern Ireland where there is, and remains, a long-standing pattern of parallel institutions and services for the different communities. A socially significant example lies in the education system where a parallel system of Catholic and Protestant schools has been in place since the establishment of a national school system in the 1830s. During the years of political violence in Northern Ireland a variety of educational interventions were implemented to promote reconciliation, but most of them failed to create any systemic change. This paper describes a post-conflict educational initiative known as Shared Education which aims to promote social cohesion and school improvement by encouraging sustained and regular shared learning between students and broader collaboration between teachers and school leaders from different schools. The paper examines the background to work on Shared Education, describes a ‘sharing continuum’ which emerged as an evaluation and policy tool from this work and considers evidence from a case study of a Shared Education school partnership in a divided city in Northern Ireland. The paper will conclude by highlighting some of the significant social and policy impact of the Shared Education work.     

IPv6将迎来应用的雪崩浪潮

在日本,所有的人都认为IPv4已经面临困境。日本的许多互联网服务供应商都在担心,如果他们还是紧抓住IPv4不放的话,其未来将何去何从。再过一年,他们就会把日本所有IPv4的地址分派完了。所以对他们来讲,时机真的已经到来了。 ——Kazuhiro Gomi     

浅析CEPA签署对中国房地产的影响--中国房地产走向国际化

在香港经济经历数次冲击之后，中央政府为促进内地和香港特别行政区经济的共同繁荣与发展，加强双方与其他国家和地区的经贸联系，达成了《内地与香港关于建立更紧密经贸关系的安排》(简称CEPA)。CEPA的实施使香港和内地的房地产业取长补短，优势互补，尤其令内地的房地产业加快了由相对“封闭”走向开放、走向国际化的步伐。     

太空站如何造福地球人

Science, medicine, and education will get aboost,says a former astronaut. A board the International Space Station,astro—nauts,cosmonauts,and scientists from around the globeare collaborating1 on science that once was thought only to befiction2.With new scientific tools at their fingertips,space sta-tion crews are working in many areas,including materials sci-ence,medicine,and Earth observation.     

Testing the TIDE: Examining the Nature of Students’ Epistemic Beliefs Using a Multiple Methods Approach

The purpose of this study was to empirically scrutinize Muis, Bendixen, and Haerle's (2006) Theory of Integrated Domains in Epistemology framework. Secondary, college, undergraduate, and graduate students completed self-reports designed to measure their domain-specific and domain-general epistemic beliefs for mathematics, psychology, and general knowledge, respectively. Following completion of the questionnaires, students participated in an interview that further probed their epistemic beliefs to better understand the nature of their beliefs. Results from our study suggest students’ beliefs across domains are somewhat related but still unique to that particular domain. Moreover, analysis of the interviews revealed that students espouse general knowledge beliefs and domain-specific beliefs. Interestingly, students expressed absolutist beliefs about mathematics, but were multiplist in their stances toward psychology and general knowledge. When asked to provide examples that came to mind when reporting their beliefs, students frequently drew on their classroom experiences to explain why they held specific beliefs. We discuss theoretical implications.     

Learning that ‘gay is okay’: educators and boys re/constituting heteronormativity through sexual health

In this paper, I draw on observations from sexual health workshops in an elementary school classroom in Vancouver, Canada and friendship pair interviews with four boys who attended the workshops. I examine how the educators organising the workshops constructed sexual health, highlighting their reliance on both a ‘gay is okay’ and a scientific discourse. I argue that by locating their discussion of homosexuality within a values framework and striving to depict gay relationships as acceptable, they simultaneously constituted homosexuality as requiring acceptance. Likewise, by subsuming references to heterosexuality within their lesson on (hetero)sexual reproduction, they framed heterosexuality as an always already accepted scientific fact. Having set the scene in this way, I then explore the ways the boys both took up and deviated from these discourses when constructing their own narratives.     

Invisibly at risk: Low‐income students in a middle‐ and upper‐class world

Women's studies programs, multicultural centers, and organizations to support gay, lesbian, bisexual, and transgender students are campus fixtures. Few now question diversity's contribution to the education of all students. Jennifer Duffy suggests that it's time to acknowledge, support, and celebrate one more form of diversity that is mostly hidden: social class.