Learning the `New, New Thing': On the role of path dependency in university structures

In current debates over thefuture of core institutions in a `knowledgesociety', universities figure most prominently. It seemsclear that they are crucial nodes in theoverall knowledge producing system, which, however,need to be repositioned and reformed.Therefore, the learning capacities ofuniversities are of central relevance. But howdo universities adapt to new challenges? Thecentral claim of the paper is that the rapidchange of pace at the level of higher educationdiscourse is hardly met at the level ofuniversities. Here, one has to take the path-dependentcharacter of their structures, practices andidentity concepts into account. Therefore, learning the`new, new thing' is a more cumbersomeprocess than might be expected at first sight.Empirical evidence for this claim is drawn fromthe institutionalization of technology transferoffices at German universities. Based on thesefindings, further general policy and researchperspectives on the role of path dependency inuniversity structures are discussed at the endof this paper.     

Liver transplantation reverses hypergammaglobulinemia in patients with chronic hepatic failure

Introduction

Sparse data are available about the effect of therapy methods on antibody levels in patients with liver failure. The aim of this study was to determine serum immunoglobulin concentrations in patients with chronic hepatic failure (CHF), acute- (ALF), or acute-on-chronic liver failure (ACLF) and to evaluate the impact of MARS treatment or liver transplantation (LT) on antibody levels.

Materials and methods

We followed ten patients with ALF, twelve with ACLF and 18 with CHF. Eight patients with ALF and seven with ACLF underwent MARS therapy, whereas the rest received LT. 13 healthy volunteers served as controls. Serum antibody concentrations were measured using ELISA-technique.

Results

Median serum levels of IgA, IgG and IgM were significantly increased in patients with CHF compared to ALF or controls (P < 0.02, P < 0.01, and P < 0.01). IgM and IgG concentrations were also significantly elevated in patients with CHF compared to ACLF (IgM, 3.7 vs. 1 g/L, P < 0.001; IgG, 8.7 vs. 3.1 g/L, P = 0.004). Immediately after LT a significant decrease of IgA (6.9 vs. 3.1 g/L, P = 0.004), IgG (8.7 vs. 5.1 g/L, P = 0.02) and IgM (3.7 vs. 1.8 g/L, P = 0.001) was detected in patients with CHF and antibody levels further decreased the days after LT reaching levels comparable to healthy individuals. MARS treatment had no apparent effect on the immunoglobulin profile in patients with ALF or ACLF.

Conclusion

We provide evidence that LT reverses hypergammaglobulinemia in patients suffering from CHF within one day, which could be explained to a reconstituted hepatic antibody clearance, whereas MARS treatment has no immediate effect on immunoglobulin levels.Key words: antibodies, immunoglobulins, liver failure, liver transplantation, artificial liver support system, molecular adsorbent recirculating system     

A key to the future: the attitudes and values of adolescent Europeans

Based on original empirical data collected from adolescents in Europe (N = 9003) this paper focuses the lifeworlds of young people. It analyses negative and positive patterns of attitude and combines them with further concepts: personal life perspectives, various key values and political attitudes. Technically, the attitude towards Europe acts as the dependent variable whereas the remaining concepts are used as independent variables. The empirical results show Turkish and Polish adolescents are more critical towards Europe than adolescents living in ‘old’ Europe. Furthermore, the data show that those who hold negative expectations about their personal futures are likely also to be Eurosceptical.     

Can international elite sport success trickle down to mass sport participation? Evidence from Danish team handball

Many scholars do not find evidence of a trickle-down effect from elite sport success to mass sport participation. Contrary to what is assumed by the trickle-down effect “theorem”, successful elite sportspeople do not seem to inspire amateurs to take up sport themselves. However, recent studies present evidence that elite sport can have an influence. In this article, we apply regression models on time series data from one of the most successful Danish sports, team handball. Our findings are mixed, but lean towards supporting scholars who argue that trickle-down effects are not necessarily an inherent part of international sporting success. Further studies should examine more sports to identify where trickle-down effects occur and why.