Modelling Molecular Mechanisms: A Framework of Scientific Reasoning to Construct Molecular-Level Explanations for Cellular Behaviour

Although molecular-level details are part of the upper-secondary biology curriculum in most countries, many studies report that students fail to connect molecular knowledge to phenomena at the level of cells, organs and organisms. Recent studies suggest that students lack a framework to reason about complex systems to make this connection. In this paper, we present a framework that could help students to reason back and forth between cells and molecules. It represents both the general type of explanation in molecular biology and the research strategies scientists use to find these explanations. We base this framework on recent work in the philosophy of science that characterizes explanations in molecular biology as mechanistic explanations. Mechanistic explanations describe a phenomenon in terms of the entities involved, the activities displayed and the way these entities and activities are organized. We conclude that to describe cellular phenomena scientists use entities and activities at multiple levels between cells and molecules. In molecular biological research, scientists use heuristics based on these intermediate levels to construct mechanistic explanations. They subdivide a cellular activity into hypothetical lower-level activities (top-down approaches) and they predict and test the organization of macromolecules into functional modules that play a role in higher-level activities (bottom-up approaches). We suggest including molecular mechanistic reasoning in biology education and we identify criteria for designing such education. Education using molecular mechanistic reasoning can build on common intuitive reasoning about mechanisms. The heuristics that scientists use can help students to apply this intuitive notion to the levels in between molecules and cells.     

Biology Teachers Designing Context-Based Lessons for Their Classroom Practice—The importance of rules-of-thumb

In science education in the Netherlands new, context‐based, curricula are being developed. As in any innovation, the outcome will largely depend on the teachers who design and implement lessons. Central to the study presented here is the idea that teachers, when designing lessons, use rules‐of‐thumb: notions of what a lesson should look like if certain classroom outcomes are to be reached. Our study aimed at (1) identifying the rules‐of‐thumb biology teachers use when designing context‐based lessons for their own classroom practice, and (2) assessing how these personal rules‐of‐thumb relate to formal innovative goals and lesson characteristics. Six biology teachers with varying backgrounds designed and implemented a lesson or series of lessons for their own practice, while thinking aloud. We interviewed the teachers and observed their lessons. Our results suggest that rules‐of‐thumb, which differed substantially among the teachers, indeed to a great extent guide the decisions teachers make when designing (innovative) lessons. These rules‐of‐thumb were often strongly associated with intended lesson outcomes. Also, teachers’ personal rules‐of‐thumb were more powerful in determining the lesson design than formal innovative goals and lesson characteristics. The results of this study encourage more research into how rules‐of‐thumb reflect teachers’ practical knowledge, for which suggestions are made.     

Expertise for Teaching Biology Situated in the Context of Genetic Testing

Contemporary genomics research will impact the daily practice of biology teachers who want to teach up-to-date genetics in secondary education. This article reports on a research project aimed at enhancing biology teachers’ expertise for teaching genetics situated in the context of genetic testing. The increasing body of scientific knowledge concerning genetic testing and the related consequences for decision-making indicate the societal relevance of an educational approach based on situated learning. What expertise do biology teachers need for teaching genetics in the personal health context of genetic testing? This article describes the required expertise by exploring the educational practice. Nine experienced teachers were interviewed about the pedagogical content, moral and interpersonal expertise areas concerning how to teach genetics in the personal health context of genetic testing, and the lessons of five of them were observed. The findings showed that the required teacher expertise encompasses specific pedagogical content expertise, interpersonal expertise and a preference for teacher roles and teaching approaches for the moral aspects of teaching in this context. A need for further development of teaching and learning activities for (reflection on) moral reasoning came to the fore. Suggestions regarding how to apply this expertise into context-based genetics education are discussed.     

A Knowledge Base for Teaching Biology Situated in the Context of Genetic Testing

Recent developments in the field of genomics will impact the daily practice of biology teachers who teach genetics in secondary education. This study reports on the first results of a research project aimed at enhancing biology teacher knowledge for teaching genetics in the context of genetic testing. The increasing body of scientific knowledge concerning genetic testing and the related consequences for decision-making indicate the societal relevance of such a situated learning approach. What content knowledge do biology teachers need for teaching genetics in the personal health context of genetic testing? This study describes the required content knowledge by exploring the educational practice and clinical genetic practices. Nine experienced teachers and 12 respondents representing the clinical genetic practices (clients, medical professionals, and medical ethicists) were interviewed about the biological concepts and ethical, legal, and social aspects (ELSA) of testing they considered relevant to empowering students as future health care clients. The ELSA suggested by the respondents were complemented by suggestions found in the literature on genetic counselling. The findings revealed that the required teacher knowledge consists of multiple layers that are embedded in specific genetic test situations: on the one hand, the knowledge of concepts represented by the curricular framework and some additional concepts (e.g. multifactorial and polygenic disorder) and, on the other hand, more knowledge of ELSA and generic characteristics of genetic test practice (uncertainty, complexity, probability, and morality). Suggestions regarding how to translate these characteristics, concepts, and ELSA into context-based genetics education are discussed.     

The three Rs of action research methodology: reciprocity,reflexivity and reflection-on-reality

This article presents an exploration of the methodology of action research. It is a reflection on a study where an action research methodology used by the researcher to research and develop theory, became part of the model of professional development. In this way, the action research methodology permeated into the culture of the way people worked together. This article describes how a researcher can not only use action research methods to gather data on a development, but can also lead a group of action researchers towards a greater awareness of their own practice in their own institutions. A greater awareness of the bigger issues in education is also an outcome achieved by facilitating critical discussion on key issues. There can be action research for research purposes, action research for action purposes and action research communities that can lead to emancipatory practices in education. These are concurrent strands within action research communities.     

Beyond direct neighbourhood effects: higher-order interactions improve modelling and predicting tree survival and growth

It is known that biotic interactions are the key to species coexistence and maintenance of species diversity. Traditional studies focus overwhelmingly on pairwise interactions between organisms, ignoring complex higher-order interactions (HOIs). In this study, we present a novel method of calculating individual-level HOIs for trees, and use this method to test the importance of size- and distance-dependent individual-level HOIs to tree performance in a 25-ha temperate forest dynamic plot. We found that full HOI-inclusive models improved our ability to model and predict the survival and growth of trees, providing empirical evidence that HOIs strongly influence tree performance in this temperate forest. Specifically, assessed HOIs mitigate the competitive direct effects of neighbours on survival and growth of focal trees. Our study lays a foundation for future investigations of the prevalence and relative importance of HOIs in global forests and their impact on species diversity.     

Using the curriculum emphasis concept to investigate teachers’ curricular beliefs in the context of educational reform

This paper reports a study on teachers’ domain‐specific beliefs about the chemistry curriculum for upper‐secondary education in The Netherlands. Teachers’ beliefs were investigated using a questionnaire focused on the goals of the chemistry curriculum. The design of the questionnaire was based on three curriculum emphases: ‘fundamental chemistry’, ‘chemistry, technology and society’, and ‘knowledge development in chemistry’. The questionnaire was administered to a sample of Dutch chemistry teachers. The results indicate that, on the whole, the curriculum emphasis ‘fundamental chemistry’ received the strongest support. This is in accordance with the content and the tradition of the Dutch chemistry curriculum. When the two types of upper‐secondary education were compared, it appeared that ‘chemistry, technology and society’ was almost equally valued for both types of education. However, the curriculum emphasis, ‘knowledge development in chemistry’, was considered much more important for pre‐university education than for senior general secondary education.     

Evaluating Portfolio Use as a Learning Tool for Professionals

We have earlier reported overall teacher emphases on six general educational goals. In the present study we present school level analyses of the same goal variables. The new focus of the present study was on possible school differences in teacher goal emphases. It is assumed that school differences may indicate a process of teacher socialisation in schools, particularly if these characteristics are relatively stable over time. About 40 schools were analysed at two points in time and they were represented by two different samples of teachers (144 and 157 teachers). We analysed both individual goal variables and goal profiles defined by how the teachers ranked the six goals. Only the 'profile approach' indicated school-specific goal priorities. The results also showed that the degree of goal consensus in schools should not be regarded as an aspect of the school climate. In addition, the measure of school goal consensus was weakly related to other examined aspects of the school climate.