Related diversification and R&D intensity dynamics

Using longitudinal data of Spanish manufacturing companies, we study the dynamic, bidirectional relationship between firm research and development (R&D) intensity and corporate diversification in an organic growth setting. Our empirical approach accounts for the different sources of endogeneity. Although we find a positive linear effect of R&D intensity on related diversification, the effect of related diversification on R&D intensity assumes the form of an inverted U. Thus, the effect of related diversification on R&D intensity is positive, but marginally decreases for moderate levels of related diversification. Such an effect can become negative, however, for high levels of related diversification. Additionally, as a consequence of dynamics, the effects after one year are substantially lower than the overall effects that occur over several years.     

Diversity and School Curriculum: the response of the Spanish educational system to the needs of academically highly able pupils

In Spain, there is a growing awareness that diversity, and the special educational needs arising out of it, are not only reflected in the social sphere and the school system but also in legislation. Legal changes since 1990 have had many implications for the education of highly able pupils: the Resolucion of 29 April 1996 extends the principles of integration and diversity to all pupils, not exclusively the handicapped. The present study overviews the possibilities under current Spanish legislation for responding and adapting to the educational needs of highly able pupils. It shows how the legislation and guiding principles of the Spanish educational system make it possible to give an effective response to educating highly able students. However, work is needed on the adaptation of diagnostic tests and curricular material, and the training of specialized professionals.     

Postural control and physiological responses to a simulated match in U-20 judo competitors

Abstract

The aim was to evaluate the effects of judo combat on the athletes’ postural control (PC) and physiological loading before, during and after a simulated match. Seventeen under-20 regional and national level athletes completed one modified 7-min match. At baseline, during the combat (3rd and 7th minutes) and 2-min post-match centre of pressure (CoP) parameters were assessed. Heart rate (HR), blood lactate (BLa) and rating of perceived exertion (RPE) and local RPE (LRPE) were collected. Significant increments were observed in CoP mean positioning and velocity at 3rd and 7th minutes, but the CoP deviation in both axes was unaffected. HR and BLa were elevated at 3rd and 7th minutes, and they remained elevated 2-min post-match. However, CoP returned to baseline 2-min post-match. RPE was elevated at 3rd and 7th minutes and the greatest effort was displayed in the Deltoid and Quadriceps. Thus, one simulated judo match stimulates a significant metabolic response and balance is degraded, with the greatest effects on the anterior–posterior axis and it recovers to baseline level after 2 min of passive rest. The physiological load cannot be regarded as a potential predictor variable of CoP. Overall, a judo match predominantly affects the upper body than the other body parts.     

An Example of the Informative Potential of Polar Coordinate Analysis: Sprint Tactics in Elite 1,500-m Track Events

Polar coordinate analysis is a powerful data reduction technique based on the Zsum statistic, which is calculated from adjusted residuals obtained by lag sequential analysis. Its use has been greatly simplified since the addition of a module in the free software program HOISAN for performing the necessary computations and producing easy-to-interpret results in the form of polar coordinate maps. In this study, we provide a simple and practical example of how this technique can be used to analyze tactical behaviors in sport and physical exercise. We studied 158 performances by 82 male runners in thirteen 1,500-m finals held at the Olympic Games, the World Championships in Athletics, and the European Athletics Championships between 2000 and 2012 to investigate associations between the initiation of sprints by race winners and other runners (focal behaviors) and the lap and zone of the track in which the sprints were initiated (conditional behaviors). The significant prospective/retrospective activating/inhibitory relationships shown in the polar coordinate maps confirm the decision to start a sprint is a tactical one and are consistent with a winning strategy consisting of avoiding giving rivals the benefit of the slipstream while conserving sufficient energy for a final winning burst. Polar coordinate analysis is a powerful technique for studying tactical behaviors in the field of sport.     

Price-effectiveness: pharmacoeconomics,value and the right price for HPV vaccines

ABSTRACT

Drawing on a pragmatist approach to pricing, this article discusses the impact of cost-effectiveness analysis (CEA) in the pricing strategies of pharmaceutical companies. Through an analysis of the human papillomavirus (HPV) vaccination, this article illustrates the strategic appropriation of evidence-based medicine (narratives and practices) that pharmaceutical companies have undertaken to enhance the value of their products. While governments are concentrated on the measurement of costs and efficiency (cost-effectiveness), companies attempt to find the threshold of effectiveness that supports their estimation of value. I have called such mode of calculation, price-effectiveness. Pharmaceutical companies engage in different ways with CEA in devising their own price strategies. First, CEA is used as an instrument to raise HPV vaccines as a matter of interest for health authorities. Second, companies produce models to maximise the effectiveness of their products. Third, the expense side of CEA has opened an opportunity to represent some conditions as diseases in order to increase the potential value of the vaccine, expressed in a higher price. Debates and practices of pricing offer a unique opportunity to trace how particular forms of quantification have become the common ground in the demonstration of value in healthcare and the adaptation of companies.     

Validity of a single lactate measure to predict fixed lactate thresholds in athletes

This study aimed to validate the use of a single blood lactate concentration measure taken following a 12 km h^?1 running stage (BLC₁₂) to predict and monitor fixed blood lactate concentration (FBLC) thresholds. Three complementary studies were undertaken. Study I: the relationships between BLC₁₂ and the running speeds at FBLC of 3 mmol L^?1 (S3mM) and 4 mmol L^?1 (S4mM) measured during a multistage running field test were examined in 136 elite athletes. Study II: data from 30 athletes tested one year apart were used to test the predictive capacity of the equations obtained in Study I. Study III: 80 athletes were tested before and after an intensified training period to examine whether training-induced changes in FBLC thresholds could be predicted and monitored by BLC₁₂. Study I: BLC₁₂ was significantly (P < 0.001) and inversely related to S3mM (R² = 0.89) and S4mM (R² = 0.95). Study II: prediction models yielded robust correlations between the estimated and measured FBLC thresholds (r = 0.94–0.99; P < 0.001). Study III: estimated changes predicted actual training-induced changes in FBLC thresholds (r = 0.81–0.91; P < 0.001). This study gives empirical support to use a single lactate measure during a sub-maximal running field test as a simple, low-cost and practical alternative to FBLC thresholds in athletes.