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41.
42.
A. Kumar D. H. Shah U. Vijayan S. R. Dandekar B. A. Krishna S. M. Sharma 《Indian journal of clinical biochemistry : IJCB》1994,9(1):19-20
Seven cases of suspected haemorrhage In pre-existing adenoma or cyst in the thyroid showed serum thyroglobulin (tg) levels
phenomenonly elevated. The serum tg leveis reduced remarkably within one to three montha. During this period all patients
were treated with thyroxin. It is concluded that serial serum thyroglobulin determinations may be useful in confirming the
clinical suspicion of haemorrhage in the thyroid. 相似文献
43.
T. Malati B. Yadagiri D. Murali Mohan Krishna V. Shantaram D. Raghunadharao K. Subbarao 《Indian journal of clinical biochemistry : IJCB》2001,16(1):52-59
In the present study, monoclonal gammapathy was identified in a total of 245 patients of plasma cell dyscrasias during period
of 1987 to 2000. The monoclonal band was identified in serum by agar gel electrophoresis in all the cases and in urine in
a few cases. Characterization of paraprotein (monoclonal immunoglobulin class and light chain type) was carried out by employing
immunoelectrophoresis and/or immunofixation electrophoresis using heavy chain specific gamma, alpha, mu, delta and epsilon
and light chain specific kappa (K), lambda (λ) antisera. Serum immunoglobulins Ig G, Ig A, and Ig M were estimated by immunoturbidometry.
Serum urea, creatinine, uric acid, alkaline phosphatase, total proteins, albumin, calcium and phosphorus were estimated by
using routine biochemical methods. Among the 245 cases, 73.1% monoclonal gammapathies were of secretory type and 7.3% were
non-secretory. Monoclonal gammapathies were associated with 80.4% of multiple myeloma, 8.9% of solitary plasmacytoma, 4.1%
of extra-medullary plasmacytoma, 3.3% of lymphoma and 2.9% of plasma cell leukemia. Classification of secretory monoclonal
immunoglobulin revealed monoclonal immunoglobulin Ig G in 74%, Ig A 15% and Ig M in 2.9% cases. 相似文献
44.
Tangirala Malati Ph. D. D. Murali Mohan Krishna B. Sadasivudu 《Indian journal of clinical biochemistry : IJCB》1991,6(1):51-57
Serum fructosamine (SFRC) was estimated using single colour reading procedure in 50 normals and 160 adult onset random diabetics.
Serum fructosamine levels were observed to be 1.86±0.321 m moles/L (Range 1.0 to 2.4) and 3.44±0.671 (Range 2.0 to 5.7) in
normal and diabetic subjects respectively. Serum fructosamine levels as determined by the method adapted, were found to be
unaffected by a transient rise in serum glucose levels during an oral glucose tolerance test. Significantly elevated SFRC
concentration was also seen in diabetic groups in spite of different combinations of antidiabetic treatment. Attempts to correlate
SFRC with duration and secondary complications of diabetes did show significant elevation in all the groups irrespective of
duration and complications thus indicating poor glycemic control. 相似文献
45.
Krishna Mohan Surapneni V. S. Chandrasada Gopan 《Indian journal of clinical biochemistry : IJCB》2008,23(1):41-44
The changes in the erythrocyte lipid peroxidation products (MDA), levels of glutathione (GSH), ascorbic acid and plasma vitamin
E (non enzymatic antioxidant parameters) and activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase
(GPX), catalase in erythrocytes and plasma glutathione - S - transferase (GST) activity were estimated in patients with rheumatoid
arthritis. This work was undertaken to assess oxidative stress and anti oxidant status in patients with rheumatoid arthritis.
It was observed that there was a significant increase in erythrocyte MDA levels, activities of SOD, GPX, plasma GST and a significant decrease in erythrocyte GSH, ascorbic acid, plasma vitamin E levels and catalse activity in
patients with rheumatoid arthritis when compared to controls. The results of our study suggests higher oxygen free radical
production, evidenced by increased MDA and decreased GSH, ascorbic acid, vitamin E and Catalase activity, support to the oxidative
stress in rheumatoid arthritis. The increased activities of antioxidant enzymes may be a compensatory regulation in response
to increased oxidative stress. 相似文献
46.
47.
Ritesh Gupta H. Krishna Prasad Kalpana M. Nagarkar A. B. Dey 《Indian journal of clinical biochemistry : IJCB》2000,15(1):40-43
Tumor necrosis factor-alpha (TNF-α) has been implicated in the pathogenesis of several non-infectious and infectious diseases
including tuberculosis. In a prospective longitudinal study, TNF-α level in blood was estimated by sandwich ELISA using anti
human TNF-α antibody, in 22 patients with active pleuro-pulmonary and lymphnode tuberculosis before and after chemotherapy
and 8 healthy controls. Six patients and six controls had detectable levels (> 5 pg/ml) of TNF-α in blood. The mean TNF-α
levels in controls and cases before and after treatment were 182.4pg/ml, 896.7 pg/ml and 678.7pg/ml pg/ml respectively. Though
not statistically significant, there was a trend towards younger age, shorter duration of symptoms, presence of fever and
anorexia, and high ESR, in patient with high serum TNF-α levels. 相似文献
48.
Amit Krishna De 《Resonance》1999,4(5):78-87
Even though research is going on throughout the world, it is clear that at the present time there is really no cure for Parkinson’s
disease. Treatment with drugs, with physiotherapy can slow down the progress of this disease. Treatment through brain grafting
or reparative therapy using different nerve growth factors may be the only alternative for this disease. Researchers are still
hoping that the newly discovered substances could one day help doctors treat this invincible disease and possibly cure it
also. 相似文献
49.
This study was interested in determining whether ethnicity-based cultural differences affected knowledge usage in today's multicultural organizations. Our empirical study uses a psychology-based approach to measure what we refer to as implicit managerial knowledge of Information and Communication Technology (ICT) workers within three Australian organizations. The research instrument captures responses to various ICT workplace scenarios in order to determine and compare the different ways in which people make use of the implicit knowledge they use to manage themselves and others. Using the culture-based literature to assist with interpretation of the data, we have identified a number of themes and their characteristics and brought these together to provide a comprehensive model for understanding cultural influences. This model can be used to better appreciate why and perhaps anticipate how an individual's implicit managerial knowledge will be used in responding to everyday workplace situations. Such an understanding will assist organizations to develop appropriate and effective knowledge management strategies. 相似文献
50.
Sepsis is an adverse systemic inflammatory response caused by microbial infection in blood. This paper reports a simple microfluidic approach for intrinsic, non-specific removal of both microbes and inflammatory cellular components (platelets and leukocytes) from whole blood, inspired by the invivo phenomenon of leukocyte margination. As blood flows through a narrow microchannel (20 × 20 µm), deformable red blood cells (RBCs) migrate axially to the channel centre, resulting in margination of other cell types (bacteria, platelets, and leukocytes) towards the channel sides. By using a simple cascaded channel design, the blood samples undergo a 2-stage bacteria removal in a single pass through the device, thereby allowing higher bacterial removal efficiency. As an application for sepsis treatment, we demonstrated separation of Escherichia coli and Saccharomyces cerevisiae spiked into whole blood, achieving high removal efficiencies of ∼80% and ∼90%, respectively. Inflammatory cellular components were also depleted by >80% in the filtered blood samples which could help to modulate the host inflammatory response and potentially serve as a blood cleansing method for sepsis treatment. The developed technique offers significant advantages including high throughput (∼1 ml/h per channel) and label-free separation which allows non-specific removal of any blood-borne pathogens (bacteria and fungi). The continuous processing and collection mode could potentially enable the return of filtered blood back to the patient directly, similar to a simple and complete dialysis circuit setup. Lastly, we designed and tested a larger filtration device consisting of 6 channels in parallel (∼6 ml/h) and obtained similar filtration performances. Further multiplexing is possible by increasing channel parallelization or device stacking to achieve higher throughput comparable to convectional blood dialysis systems used in clinical settings. 相似文献