Preanalytical management: serum vacuum tubes validation for routine clinical chemistry

Introduction

The validation process is essential in accredited clinical laboratories. Aim of this study was to validate five kinds of serum vacuum tubes for routine clinical chemistry laboratory testing.

Materials and methods:

Blood specimens from 100 volunteers in five diff erent serum vacuum tubes (Tube I: VACUETTE^®, Tube II: LABOR IMPORT^®, Tube III: S-Monovette^®, Tube IV: SST^® and Tube V: SST II^®) were collected by a single, expert phlebotomist. The routine clinical chemistry tests were analyzed on cobas^® 6000 module. The significance of the diff erences between samples was assessed by paired Student’s t-test after checking for normality. The level of statistical significance was set at P < 0.005. Finally, the biases from Tube I, Tube II, Tube III, Tube IV and Tube V were compared with the current desirable quality specifications for bias (B), derived from biological variation.

Results and conclusions:

Basically, our validation will permit the laboratory or hospital managers to select the brand’s vacuum tubes validated according him/her technical or economical reasons, in order to perform the following laboratory tests: glucose, total cholesterol, high density lipoprotein-cholesterol, triglycerides, total protein, albumin, blood urea nitrogen, uric acid, alkaline phosphatise, aspartate aminotransferase, gamma-glutamyltransferase, lactate dehydrogenase, creatine kinase, total bilirubin, direct bilirubin, calcium, iron, sodium and potassium. On the contrary special attention will be required if the laboratory already performs creatinine, amylase, phosphate and magnesium determinations and the quality laboratory manager intend to change the serum tubes. We suggest that laboratory management should both standardize the procedures and frequently evaluate the quality of in vitro diagnostic devices.     

The importance of the International Tennis Federation's junior boys' circuit in the development of professional tennis players

The relationship between junior boys' tennis success, as measured by a top 20 International Tennis Federation's Junior Circuit (ITFJC) ranking, and subsequent ranking accomplishments in professional men's tennis is discussed. The names, countries, and birthdates of all players to achieve a top 20 ITFJC boys' year-end ranking from 1992 to 1998 were recorded. The progress of these players through the professional ranks was then tracked to the end of 2004. Results indicate that 91% of top 20-ranked boys achieved a professional men's ranking, while a stepwise regression analysis revealed junior ranking (JR) to be a predictor of future, professional ranking (beta = 0.232, r(2) = 0.054, p < 0.05). A regression equation [predicted professional rank = 78.17 + 6.31*(JR)] accounted for a significant amount of variance in professional ranking. For male players, therefore, the achievement of a top 20 junior ranking appears to be a reasonable yardstick for future, professional success. The type of surface upon which junior players develop their games was also shown to influence professional ranking highs, with play on clay courts or a combination of clay and hard courts helping to produce higher, professionally ranked players than hard court play alone (p< or = 0.01).     

Enhancing web search in the medical domain via query clarification

The majority of Internet users search for medical information online; however, many do not have an adequate medical vocabulary. Users might have difficulties finding the most authoritative and useful information because they are unfamiliar with the appropriate medical expressions describing their condition; consequently, they are unable to adequately satisfy their information need. We investigate the utility of bridging the gap between layperson and expert vocabularies; our approach adds the most appropriate expert expression to queries submitted by users, a task we call query clarification. We evaluated the impact of query clarification. Using three different synonym mappings and conducting two task-based retrieval studies, users were asked to answer medically-related questions using interleaved results from a major search engine. Our results show that the proposed system was preferred by users and helped them answer medical concerns correctly more often, with up to a 7 % increase in correct answers over an unmodified query. Finally, we introduce a supervised classifier to select the most appropriate synonym mapping for each query, which further increased the fraction of correct answers (12 %).     

Founders’ human capital and the growth of new technology-based firms: A competence-based view

In this paper, we analyze empirically the relation between the growth of new technology-based firms and the human capital of founders, with the aim of teasing out the “wealth” and “capability” effects of human capital. For this purpose, we take advantage of a new data set relating to a sample composed of 506 Italian young firms that operate in high-tech industries in both manufacturing and services. In accordance with competence-based theories, the econometric estimates show that the nature of the education and of the prior work experience of founders exerts a key influence on growth. In fact, founders’ years of university education in economic and managerial fields and to a lesser extent in scientific and technical fields positively affect growth while education in other fields does not. Similarly prior work experience in the same industry of the new firm is positively associated with growth while prior work experience in other industries is not. Furthermore, it is the technical work experience of founders as opposed to their commercial work experience that determines growth. The fact that within the founding team there are individuals with prior entrepreneurial experiences also results in superior growth. Lastly, we provide evidence that there are synergistic gains from the combination of the complementary capabilities of founders relating to (i) economic-managerial and scientific-technical education and (ii) technical and commercial industry-specific work experiences. We conclude that the human capital of founders of new technology-based firms is not just a proxy for personal wealth.