Imbalanced free radicals and antioxidant defense systems in schizophrenia： A comparative study

Objective： To examine changes of blood oxidative-antiovidative level in schizophrenic patients and its relationship with clinical symptoms. Methods： Forty-six Chinese patients met DSM-IV （Diagnostic and Statistical Manual of Mental Disorders-iV） criteria for schizophrenia and fifty age- and sex-matched healthy controls were enrolled in the present study. Baseline psychiatric symptom severity was assessed with brief psychiatric rating scale, positive and negative syndrome scale on the blood draw day. Fresh blood samples were collected to measure levels of nitric oxide and lipid peroxide in plasma as well as activities of superoxide dismutase, catalase and glutathione peroxidase in red blood cells by spectrophotometric assays simultaneously. Results Comparison of the biochemical parameters indicated that the level of nitric oxide and lipid peroxide increased in patient group, which represented a positive correlation with positive scale scores; while the activities of three critical enzymes decreased and showed a negative linear correlation. Conclusion： This study showed that there are dysregulation of free radical metabolism and poor activities of the antioxidant defense systems in schizophrenic patients. Excess free radicals formation may play a critical role in the etiology of schizophrenia. Using antioxidants might be an effective therapeutic approach to partially alleviate or prevent the symptoms of schizophrenia.     

论我国商业秘密法律保护的完善

我国商业秘密法律保护工作起步较晚,机制不健全,商业秘密意识普遍不强。为适应商业秘密保护的国际化趋势,必须尽快完善我国商业秘密保护的立法和执法。     

从教学过程设计转向信息技术支持的学习环境设计

由于中美两国历史文化背景的差异,在学科演化和发展上也呈现不同的道路,引进的教学设计在中国遭到了已有的"教学论"的质疑。对教学设计的概念重新进行梳理后,重新解读了中国的"教学设计"的内涵,以期能抛砖引玉,促进教学设计在中国的健康发展。     

基于ANP的毕业要求达成度评价解析

毕业要求达成度是基于成果导向教育模式(Outcomes--based Education,OBE)的核心概念,对其评价的合理性直接影响到OBE教育模式的实施效果。传统的相关评价中存在教育过程性因素考查不充分、指标不独立引起的信息损失过多、评价方法使用受限、评价结果不准确等问题,而基于网络层次分析法(ANP)的毕业要求达成度评价可在一定程度上解决这些问题。该评价方法不仅有效融入了教育全过程因素,而且充分考虑了各指标间的关联性,能够反映出全部指标的相对重要度,减少了信息损失,更符合OBE中毕业要求达成度的评价要求。     

The Development and Design of a Framework to Match Mentees and Mentors Through a Systematic Review andThematic Analysis of Mentoring Programs Between 2000 and 2015

ABSTRACT

The need for longitudinal and holistic support of medical students throughout their training has led to the development of formal mentoring programs. Whilst success of formal mentoring programs has been attributed to (a) pairing mentees with trained and experienced mentors (matching), (b) the quality of mentoring interactions and (c) the presence of a nurturing environment, little attention has been attributed to establishing an effective matching process in medical school. We sought, in this review, to redress this gap within the context of matching medical students for mentoring. Modified PRISMA guidelines were followed to guide the review process. PubMed, ERIC, Cochrane Database, OVID and ScienceDirect databases were searched for articles on matching in medical schools and in allied health specialities published between 2000 and 2015.     

高职院校“双师型”教师自主评价的问题及对策

加强“双师型”教师自主评价是完善高职院校教师评价制度、提升高职院校教师队伍质量的重要保障。目前,高职院校“双师型”教师自主评价存在教师自评审视不够深入、自评标准缺乏科学设计、自评实施缺乏外部依据等比较明显的问题。基于对现状的分析,提出如下的建议：科学认识教师评价,建立反思性为主的教师自评机制;科学制定评价指标,构建可操作的教师自评体系;创设制度环境,保障教师自评与他评有机结合等。     

高中学业水平合格性考试命题难度控制技术的探究——以信息技术学科为例

高中信息技术学业水平合格性考试作为标准参照性考试,命题过程需要按照考试目标及要求做好难度控制,通过准确预估试题难度控制试卷难度,实现考试结果与考试目标的一致。命题难度控制技术包括试题的难度预估、试卷难度的控制。通过确定影响难度的主要客观因素、设计简便易行的试题难度计算方法、建立试题难度预估的参照模型等三个环节探究试题难度预估的方法,结合实例进一步探究试卷难度的控制技术。     

谈教会学校在九江近现代教育史中的地位与影响

一九江是长江中游的战略要地和鱼米之乡，早为外国殖民者所垂涎。１８５８年丧权辱国的《天津条约》签订后，九江沦为外国列强的通商口岸，帝国主义在这里强占租界，控制海关，洋商和传教士乘机涌入。由此，九江成为殖民侵略者的政治、经济、文化的据点。自１８６７年起，九江地区各市、县和庐山都有洋人办的教会学校，其中以美国为主，法国次之。他们以“信仰上帝”和“文化开发”为由，创办由教会控制的大、中、小学，目的是利用教会创办学校作为工具，为帝国主义利益服务。１８８１年，美籍库思非博士建起了九江第一所教会中学，并以《中…     

解析莎士比亚戏剧《麦克白》中麦克白悲剧命运的不可避免性

亚里士多德的极为重要的悲剧理论——悲剧主角的过失论,通过对来自与外界影响因素和麦克白自身因素的分析,得出最终导致麦克白的悲剧命运的是他难以抵抗外界因素的诱惑和自身对权利的极度热衷。正是因为悲剧主角的过失论,更好地说明了麦克白的悲剧命运的不可避免性。     

完善滨海新区企业直接融资体系

天津滨海新区的开发和开放已经纳入国家总体发展战略布局,天津市政府正在按照国务院部署和要求,加快滨海新区的规划和建设,以更好地服务和带动环渤海区域经济的发展.滨海新区近期的金融改革创新主要包括四项:拓宽直接融资渠道、开展金融机构综合经营、创新和完善金融机构体系、外汇管理改革.其阶段性改革创新任务的重点是拓宽直接融资渠道,提高社会资金使用效率.