金融危机冲击下行业协会的职能发挥——广东、浙江两地的经验证据

2008年底席卷全球的金融危机发生后,我国行业协会如何发挥服务及代表职能帮助企业予以应对,会员企业对于行业协会的职能有何诉求,其满意程度如何?文章在对广东和浙江两省的行业协会和会员企业进行问卷调查的基础上,通过统计分析得出了若干富于启示的结论。     

基于知识流的产业集群知识管理过程研究

介绍了产业集群的特征,对知识流进行了概述,建立了产业集群内外知识流模型,并就基于知识流的产业集群知识管理过程进行了相应的讨论.     

发明专利与大型企业利润的相关性研究

在对大型企业发明专利数和企业利润进行典型相关分析的基础上,应用统计学软件对两者进行格兰杰检验,证明了发明专利数对企业利润的正向影响作用,并计算出发明专利数每提升1%利润相应的提升0.5615%。对研究结论进行了经济学分析,阐述发明专利和基础研究投入之间的关系,并结合时间滞后性,解析了我国大型企业基础研究资金投入量不足的原因。     

Guazia,the earliest ovule without cupule but with unique integumentary lobes

The earliest ovules in the Late Devonian (Famennian) are surrounded by a cupule that is involved in both protection and pollination, and generally have free integumentary lobes. Here we report a new taxon from the Famennian of China, Guazia dongzhiensis gen. et sp. nov. The terminally borne ovule is apparently acupulate (without cupule) and has four radially arranged wing-like integumentary lobes that are extensively fused, and folded lengthwise and inwards. Guazia provides evidence that not all Devonian seeds possess a cupule and it increases their diversity in integumentary lobes. This genus also suggests that the integuments develop new functions, probably including wind dispersal at the expense of the cupules.     

中国畜禽粪便养分资源总量及替代化肥潜力

明确畜禽粪便资源数量及养分总量,计算其替代化肥潜力,对指导实现化肥零增长和减施增效具有重要意义.本文研究的畜禽种类包括牛、马、驴、骡、猪、羊、家禽和兔,利用排泄系数法估算了1980-2016年中国畜禽粪便的养分资源总量,并计算畜禽粪便替代化肥潜力.结果显示:①1980-2016年畜禽粪便和养分资源总量呈快速增长—稳定发...     

居民视角下民族社区旅游化的空间演变过程及特征——以肇兴侗寨为例

从空间角度揭示旅游化的演变过程和特征可为深刻理解社区现象或问题提供参考.本文选取肇兴侗寨为案例地,通过2013年、2018年2次实地调查,采用参与式制图和半结构访谈获取一手数据,运用景观价值理论和质性空间分析方法,通过居民视角的景观价值变化探索社区旅游化在空间上的演变过程与特征.研究发现:①肇兴侗寨社区旅游化的过程包括...     

原创性基础研究的内涵分析及对原创探索计划项目的启示

原创性基础研究是推动科学技术发展的关键动能,是引领新一轮科技革命和产业变革的源头供给。为进一步强化对原创性基础研究的资助工作,国家自然科学基金委员会将实施原创探索计划作为深化改革的重点工作之一。文章通过对原创性基础研究的概念和特征进行研究分析,结合调研国外主要科学资助机构关于原创性基础研究项目的资助导向,进一步探讨原创性基础研究的内涵和定位,在此基础上为促进原创思想的发现和识别、优化原创探索计划项目的申请与评审管理工作提出具体建议,以期进一步促进我国原创性基础研究。     

Ecological principle meets cancer treatment: treating children with acute myeloid leukemia with low-dose chemotherapy

Standard chemotherapy regimens for remission induction of pediatric acute myeloid leukemia (AML) are associated with significant morbidity and mortality. We performed a cohort study to determine the impact of reducing the intensity of remission induction chemotherapy on the outcomes of selected children with AML treated with a low-dose induction regimen plus granulocyte colony stimulating factor (G-CSF) (low-dose chemotherapy (LDC)/G-CSF). Complete response (CR) after two induction courses was attained in 87.0% (40/46) of patients receiving LDC/G-CSF. Post-remission therapy was offered to all patients, and included standard consolidation and/or stem cell transplantation. During the study period, an additional 94 consecutive children with AML treated with standard chemotherapy (SDC) for induction (80/94 (85.1%) of the patients attained CR after induction II, P = 0.953) and post-remission. In this non-randomized study, there were no significant differences in 4-year event-free (67.4 vs. 70.7%; P = 0.99) and overall (70.3 vs. 74.6%, P = 0.69) survival in the LDC/G-CSF and SDC cohorts, respectively. After the first course of induction, recovery of white blood cell (WBC) and platelet counts were significantly faster in patients receiving LDC/G-CSF than in those receiving SDC (11.5 vs. 18.5 d for WBCs (P < 0.001); 15.5 vs. 22.0 d for platelets (P < 0.001)). To examine the quality of molecular response, targeted deep sequencing was performed. Of 137 mutations detected at diagnosis in 20 children who attained hematological CR after two courses of LDC/G-CSF (n = 9) or SDC (n = 11), all of the mutations were below the reference value (variant allelic frequency <2.5%) after two courses, irrespective of the treatment group. In conclusion, children with AML receiving LDC/G-CSF appear to have similar outcomes and mutation clearance levels, but significantly lower toxicity than those receiving SDC. Thus, LDC/G-CSF should be further evaluated as an effective alternative to remission induction in pediatric AML.     

基于系统评价法的政策创新研究综述——对Web of Science核心集文献的分析

本文创新性地采用系统评价的分析框架，并结合复杂网络理论方法，综合分析了国外政策创新研究的文献内容和共引网络，归纳了政策创新研究的案例地、研究方法、政策类型等方面特征；将政策创新的研究内容划分为10个主题，并总结了气候环境相关政策创新研究、中国与美国政策创新研究、政策创新中竞合关系研究三大方向。总体来看，政策创新内涵及其评价研究是政策创新研究关注的焦点，同时，政策创新研究呈现出基于现实案例、政府统计数据及政策执行情况，且有较强的客观性等特点。未来的政策创新研究将呈现转向快速发展国家、聚焦全球共性政策突破、工具和方法综合化以及数据来源多样化等四大新趋势。     

自有知识、知识溢出与区域创新产出

立足于区域边界的内外部视角,将创新活动的知识资源划分为自有知识和知识溢出两部分,利用2009—2016年中国30个省（市、自治区）的面板数据,运用OLS和分位数回归方法,实证分析了自有知识、知识溢出对区域创新产出的影响。OLS回归结果表明：自有知识对区域创新产出具有显著正向影响,而知识溢出的影响显著为负;自有知识的主效应大于知识溢出,且二者在影响区域创新过程中存在显著的协同效应。分位数回归结果表明：随着分位点的提高,自有知识对区域创新产出的促进效应先升后降;知识溢出对区域创新产出除在0.25分位点没有显著影响外,在其他分位点均存在显著负向影响;自有知识与知识溢出的交互效应在区域创新产出不同分位点的影响不一致。