启蒙时代一曲"人"的赞歌——试论卢梭自传《忏悔录》的开创性意义

法国伟大的启蒙思想家卢梭的自传性作品<忏悔录>,以其杰出的思想性和艺术性成为传记文学史上的不朽之作,并对后世产生了深远的影响.本文拟通过分析<忏悔录>中的传主形象、思想内涵及其影响,来探讨传记文学作品写作中的一些规律性的问题.     

基于.NET平台的开放式实验室管理系统

采用．net组件技术、B／S体系结构和SQL Server数据库设计了开放式实验室管理系统。系统分管理员、教师、学生三个子平台,并对其关键的功能模块进行了深入的分析研究。     

Neurochip based on light-addressable potentiometric sensor with wavelet transform de-noising

Neurochip based on light-addressable potentiometric sensor(LAPS),whose sensing elements are excitable cells,can monitor electrophysiological properties of cultured neuron networks with cellular signals well analyzed.Here we report a kind of neurochip with rat pheochromocytoma(PC12) cells hybrid with LAPS and a method of de-noising signals based on wavelet transform.Cells were cultured on LAPS for several days to form networks,and we then used LAPS system to detect the extracellular potentials with signals d...     

Effect of high glucose levels on the calcification of vascular smooth muscle cells by inducing osteoblastic differentiation and intracellular calcium deposition via BMP-2/Cbfα-1 pathway

In this paper,we investigate the effect and the possible mechanism of high glucose levels on the calcification of human aortic smooth muscle cells (HASMCs).HASMCs were divided into four groups: normal glucose group (NG),osmolality control group (OC),high glucose group (HG,HASMCs culture medium containing 30 mmol/L glucose),and high glucose plus recombinant human Noggin protein (bone morphogenetic protein-2 (BMP-2) antagonist) group (HN).The mRNA levels and the protein expressions of BMP-2 and core binding factor alpha-1 (Cbfα-1) were measured by real-time quantitative polymerase chain reaction (PCR) and Western blot.After induced by 10 mmol/L β-glycerol phosphoric acid,cells were harvested for assessments of alkaline phosphatase (ALP) activities at Days 1,2,and 3,and intracellular calcium contents at Days 7 and 14,respectively.High glucose levels increased the mRNA levels and the protein expressions of BMP-2 and Cbfα-1 (P0.05).The expression of Cbfα-1 was partially blocked by Noggin protein (P0.05),while BMP-2 was not (P0.05).After being induced by β-glycerol phosphoric acid,high glucose levels increased the ALP activity [(48.63±1.03) vs.(41.42±2.28) U/mg protein,Day 3;P0.05] and the intracellular calcium content [(2.76±0.09) vs.(1.75±0.07) μmol/mg protein,Day 14;P0.05] in a time-dependent manner when compared with the NG group,while the ALP activity could not be blocked by Noggin protein [(48.63±1.03) vs.(47.37±0.97) U/mg protein,Day 3;P0.05].These results show that high glucose levels can evoke the calcification of HASMCs by inducing osteoblastic trans-differentiation and intracellular calcium deposition via the BMP-2/Cbfα-1 pathway,which can be partially blocked by Noggin protein.     

生产实习中培养制药工程人才的思考

生产实习教学是培养制药工程人才的重要环节.周密的安排和运作实施是圆满完成生产实习的关键.通过加强生产实习,开展校企多方合作,可以解决实习难问题,可以提高学生的工程能力、创新意识和社会适应能力,可以提高教师队伍的教学水平.     

安阳地区无公害蔬菜生产现状及对策探讨

探讨了豫北地区安阳市无公害蔬菜发展现状,分析了该区蔬菜生产受污染的几种原因以及不同的防控技术和措施等。     

英汉互译策略之"归"与"异"

本文从翻译本质和根本目的角度出发,探讨了＂归化＂、＂异化＂两种翻译策略,它们共同服从和服务于翻译的根本目的,相互联系、相互作用,并在一定条件下可以相互转换,对翻译实践具有重要的作用和意义。     

Simulation of top-down crack propagation in asphalt pavements

Top-down crack in asphalt pavements has been reported as a widespread mode of failure.A solid understanding of the mechanisms of crack growth is essential to predict pavement performance in the context of thickness design,as well as in the design and optimization of mixtures.Using the coupled element free Galerkin (EFG) and finite element (FE) method,top-down crack propagation in asphalt pavements is numerically simulated on the basis of fracture mechanics.A parametric study is conducted to isolate the effects of overlay thickness and stiffness,base thickness and stiffness on top-down crack propagation in asphalt pavements.The results show that longitudinal wheel loads are disadvantageous to top-down crack because it increases the compound stress intensity factor (SIF) at the tip of top-down crack and shortens the crack path,and thus the fatigue life descends.The SIF experiences a process "sharply ascending—slowly descending—slowly ascending—sharply ascending again" with the crack propagating.The thicker the overlay or the base,the lower the SIF; the greater the overlay stiffness,the higher the SIF.The crack path is hardly affected by stiffness of the overlay and base.     

浅析外贸英语函电情景教学法的应用

高职外贸函电英语教学采用情景教学法,使学生了解工作岗位的要求,快速融入到实际业务环境中,通过真实的业务情景,提高学生兴趣中,完成所学知识,培养自主能力.     

清末京官俸制改革探析

晚清财政窘迫,文官俸禄遭到大幅削减,俸制体系名存实亡,以致陋规盛行,严重腐蚀清统治基础。清末＂新政＂,对文官俸制进行改革,但囿于财政困难,官僚集团内部政令不一,俸制改革走向失败。但是俸制改革中体现的高薪养廉、晋级加俸、实行激励机制等原则和措施,体现出清末俸制体系向近代俸制的初步转型。