Convergent genomic signatures of high-altitude adaptation among domestic mammals

Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10orf67, which underwent positive selection in three of the domestic mammals. Our data provide an insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway.     

Understanding divergent domestication traits from the whole-genome sequencing of swamp- and river-buffalo populations

Domesticated buffaloes have been integral to rice-paddy agro-ecosystems for millennia, yet relatively little is known about the buffalo genomics. Here, we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals (132 swamp buffaloes and 98 river buffaloes) sampled from across Asia and Europe. Beyond the many actionable insights that our study revealed about the domestication, basic physiology and breeding of buffalo, we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior, digestion metabolism, strengths and milk production.     

城市规划中GIS技术的应用

城市是一个复杂的系统,城市规划主要是研究城市。新兴技术GIS的出现给城市规划领域带来许多新的变化,包括分析方法和作图方式。这些变化将提高工作的效率和成果的科学性。     

教师在工作中的自我认识

本文阐述了如何认识教师的工作压力,如何正确对待别人对自己工作的评价,要重视教师心理保健。     

税法与会计制度差异成因分析

众所周知,目前我国税法和会计制度有一定的差异,有的甚至相冲突。特别是新《企业会计准则》颁布以后,从某种程度上说,这种差距正在日益扩大,使得企业不得不增加成本去进行纳税调整。这种差异所导致的成本是否应该一定由企业来承担呢?国家对于两种制度的协调是否有原则性的指导方向等等,这些问题的解决都需要从两者最基本的原则谈起,本文将以世界主要国家模式选择为背景,立足于我国实践,以历史发展为线索,从原则层面分析两者产生的原因。     

在兴利除弊中构建具有时代精神的校园网络新文化

随着教育信息化的普及,校园网络文化对传统校园文化提出了前所未有的挑战。如何在坚持传统校园文化优势的基础上,利用网络开放性、互动性、多元性及快捷的特点,充分挖掘校园网潜力以发挥学生的个性特长,使学生面对海量的网络信息学会选择和鉴别,培养他们的批判思维和自律意识,构架学生走向未来社会的全面知识结构和综合能力素质,在兴利除弊中构建具有时代精神的校园网络新文化,是现代计算机教育不容回避的重要课题。     

杜威的道德教育观对我国学校道德教育的启示

社会转型期的背景下,传统学校道德教育表现出越来越多的不适应性,如何正视学校道德教育的低效现象,剖析其问题所在是当前德育工作者迫切需要做的。本文试图从分析当前我国学校通德教育低效的问题出发,借鉴杜威的道德教育观,从学生主体性、知识观和方法论三个层次对当前我国学校道德教育的建设提出一点启示。     

由书法创作到潜意识的阐释

书法书写中潜意识的形成以扎实的基本功和渊博的字外涵养为支撑点,经典的“过去经验”是书法创作者潜意识形成的基本的材料。书法创作者的心态环境是潜意识外化的基本条件。成功的书法创作是书法作者潜意识充分外化的表现。     

新课程背景下创建学习型教师队伍的思考

新课程的实施,动摇了教师已有知识的权威地位。作为新课程的组织者、帮助者、指导者和实施者,面临的最大挑战是自身发展,因此,教师必须树立终身学习的理念,保持不断改革进取的心态。而创建学习型教师队伍,不失为提升教师质量,促进教师主动发展的好办法。一、什么叫“学习型教师队伍”学习型组织的本质特征,是善于不断学习。它的内涵包括:一是强调“全员学习”,即全体成员全身心投入,并有持续增长的学习力;二是强调“全程学习”,即工作学习化,学习工作化,不仅善于学习,而且学以致用;三是强调“团体学习”,不但重视个人学习和个人智力的开发,…     

Fear as political dynamics: Chinese peasant workers’ struggle over social security

This article attempts to understand the subject formation of Chinese peasant workers by exploring the emotional dynamics of their struggle for social security, in particular, the new political possibilities created by emotional forces, and the complex ways they experience and articulate the distinctive kind of emotional politics that binds peasant workers with the state in their co-production of emotionally charged power relations, identities, and subjectivities. It formulates an analytical framework that explores the emotional politics of fear that plays out in the context of economic restructuring. In contemporary China, the conflict triggered by social insurance contributions has become a component of the ensuing social crisis, where many protest events are triggered by widespread outrage at the violation of legal rights to social insurance and other welfare security. This research focuses on the struggle of a group of peasant workers at a UNIQLO supplier in Shenzhen, exploring how their fears for the future are constituted, and how their emotional feelings of insecurity motivate collective action and reconfigure their emotional identity and subjectivity in the face of extreme risk. Informed by a relational understanding of emotions, this paper investigates the complex ways in which the proliferation of fear, as a result of an anticipated pain in the future, articulates the process of subject-making in the face of increasing instability and precarity. The study attempts to demonstrate the centrality of fear for China’s sociopolitical order and the radical action of labor resistance.