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141.
The number of university–industry R&D partnerships (UIPs) has increased significantly over the past decade, in most OECD countries and in Australia, yet the study of risk in such commercially focused collaborative ventures is still a developing area. This review paper seeks to contribute to debate on this increasingly important phenomenon by addressing three key areas of risks for universities in entering such collaborations. The commercialization of research findings presents particular risks to universities, most notably the possibility of financial loss, which has a greater impact than for companies in cross‐sector collaborations. Another major type of risk faced by universities is relational risk, and this can significantly alter the trust dynamics that underpin research and innovation. There are also institutional risks to universities and their research staff engaged in commercializable R&D and, ultimately, to their reputation as a neutral source of expertise. It is argued there is a need for universities in Australia to develop comprehensive policies to manage the risks of commercialization and R&D collaboration with industry partners. 相似文献
142.
Rita Christopher K. Taranath Shetty 《Indian journal of clinical biochemistry : IJCB》1996,11(1):81-84
The renal Fanconi syndrome which results from renal tubular dysfunction can be either associated with various inbom errors of metabolism or acquired from various etiology. We report a case of gentamycin-induced Fanconi syndrome in a 4-month old infant who presented with aminoaciduria, glucosuria, phosphaturia and compensated metabolic acidosis. 相似文献
143.
Yashika Gupta V. Mallika D. K. Srivastava 《Indian journal of clinical biochemistry : IJCB》2005,20(1):87-94
Platelets play a vital role in the progression of atherosclerosis and thrombosis, a major cause of death worldwide. Platelets
are activated by many triggers like elevated LDL in blood resulting in aggregation and formation of plaque. The purpose of
this study was to investigate the effect of LDL and signal transduction inhibitor on the activation of platelets in Ischaemic
risk subjects. Platelets from IHD and hyperlipidemic subjects were hypersensitive to ADP, as higher levels of platelet aggregation
were observed in these groups. LDL from IHD hyperlipidemic subjects was more effective in activating platelets from any other
group. Ox-LDL was more effective in activating platelets than native-LDL as monitored by level of platelet aggregation induced
by PAF and thrombin. Calcium channel blocker, nifedipine and verapamil inhibited platelet aggregation at micromolar level.
Protein kinase inhibitor, staurosporine was effective in inhibiting ADP induced aggregation at nanomolar level. 相似文献
144.
Urinary citric acid and calcium levels have been estimated in the urine of 20 normal healthy persons as well as 12 urinary
stone patients. Inhibition efficiency of these urine samples towards the mineralisation of urinary stone forming minerals,
viz., calcium phosphate, oxalate or carbonate, has been studied in an experimental model. Statistical correlation of the above
data has been made by computing the coefficient of determination and unexplained variance. Clinico-biochemical indexing of
calcium urolithiasis risk factor has been attempted in the light of the data. 相似文献
145.
K. S. S. Saibaba P. V. L. N. Srinivasa Rao K. V. Dakshina Murty M. Vijaya Bhaskar 《Indian journal of clinical biochemistry : IJCB》1997,12(2):139-141
Selecting the correct method for routine analysis by ‘method evaluation’ is an important component of quality assurance. It
is a step-wise procedure that evaluates various analytical parameters like accuracy, precision etc of the given method. Finally
reference intervals are established for selected population. We evaluated an enzymatic method for serum creatinine. The results
show that it is an acceptable method based on the above mentioned criteria. 相似文献
146.
147.
K. A. Faseehuddin Shakir Basavaraj Madhusudhan 《Indian journal of clinical biochemistry : IJCB》2007,22(1):117-121
Rats fed with hypercholesterolemic diet showed a significant increase in serum total—cholesterol, liver homogenate total-cholesterol,
HDL-cholesterol and changed LDL-cholesterol, and HDL/LDL ratio in comparison to control. Flaxseedchutney (FC) supplemented diet (15%, w/w) was found to be more effective in restoring lipid profile changes in rats fed with cholesterol,
(1.0%). The activities of serum marker enzymes glutamate oxaloacetate transminase (GOT), glutamate pyruvate transaminase (GPT)
and alkaline phosphatase (ALP) were elevated significantly in carbon tetrachloride induced rats. Administration of flaxseedchutney (15%, w/w) resulted in depletion of serum marker enzymes and exhibited recoupment thus showing significant hepatoprotective
effect. It was observed that flaxseedchutney supplemented diet could lower the serum cholesterol and as a potential source of antioxidants it could exert protection against
hepatotoxic damage induced by carbon tetrachloride (CCl4) in rats. 相似文献
148.
J. Baxi Kavita Sharma Rajbala Asha Mehta A. K. Pendse P. P. Singh 《Indian journal of clinical biochemistry : IJCB》1994,9(1):47-49
Evaluation of serum SOD and MDA level was done in 21 first episode renal stone formers, 9 recurrent stone formers, 20 patients with obstructive uropathy other than urolithiasis and 12 patients with urinary infection. Twenty-two healthy volunteers were taken as controls. The level of SOD in respective groups was 2.12±0.84, 2.78±0.85, 1.42±0.31, 1.98±0.70 and 2.32±0.62 units/ml and of MDA was 2.61±1.07, 2.69±1.15, 1.65±0.33, 1.33±0.34 and 1.55±0.48 n mol/ml respectively. The results indicate increased peroxidative stressin nephrolithiasis only. Since SOD level was normal in all groups, this increased peroxidative stress in nephrolithiasis should be due to factors other than this one. 相似文献
149.
150.
Diabetes Mellitus in obese and non-obese Indian individuals.AIMS: Effect of Obesity and insulin resistance on diabetic control.SETTINGS AND DESIGN: 50 each groups Diabetic individuals obese and non-obese.METHODS AND MATERIAL: On selected 50 each group diabetic patient and normal, following blood investigations has been performed—Plasma Glucose,
Glycohemoglobin and Serum Insulin.STATISTICAL ANALYSIS USED: Individuals patient’s results were analyzed and compared with the normal controls.RESULTS AND CONCLUSION: The changes in glycosylated haemoglobin are mainly proportional to the post lunch glucose level (r=0.773) (p<0.01) and not
correlated to circulating insulin or the body mass index. However the levels were higher in obese diabetes (Type I and II
both) than in non-obese. Mechanism of resistance in insulin receptor interactions due to obesity is well known. However, obesity
does not seem to affect directly glycosylated haemoglobin. Under such circumstances, the reduction of weight for a diabetic
person can improve sugar control by minimizing insulin resistance and thereby can improve glycosylated haemoglobin levels. 相似文献