卡维地洛治疗重度心衰疗效观察

目的:观察重度心衰患者应用卡维地洛的临床疗效.方法:132例心功能NYHA分级Ⅲ、Ⅳ级的心力衰竭患者随机分为卡维地洛组及常规治疗组,前组除常规治疗外加用卡维地洛6.25mg/d,渐加至50～100mg/d或最大耐受量.观察治疗3个月后心率及应用彩色多普勒超声心动图方法观察每搏量(SV)、心输出量(CO)、射血分数(EF)及左室舒张末期内径(EDD)的变化.结果:卡维地洛组治疗重度心衰有效率显著高于常规治疗组.卡维地洛组用药前后非常显著地降低了HR、EDD,提高了SV、EF、CO(P＜0.01),而常规治疗组仅HR及SV改善明显(P＜0.05).卡维地洛组HR较常规治疗组有显著降低(P＜0.05),而其它指标均较常规治疗组有非常显著改善(P＜0.01).结论:卡维地洛能显著改善心脏功能,副作用小,可安全用于重度心力衰竭的治疗.     

细胞应激和氧化还原活性蛋白参与硫氧还蛋白-1高表达幽门螺杆菌感染所致胃黏膜的癌变（英文）

目的:探索高表达硫氧还蛋白-1(Trx1)的幽门螺杆菌在致胃黏膜癌变过程中的作用机制。创新点:首次分析临床分离菌株感染蒙古沙土鼠的胃黏膜疾病动物模型,首次对不同菌株感染所致的胃黏膜癌变相关分子机制进行探索。方法:用同位素标记相对和绝对定量(i TRAQ)蛋白质组学及生物信息学分析方法进行分析,并用免疫印迹法(Western blot)对重要分子进行验证。结论:高表达Trx1的幽门螺杆菌在致胃黏膜癌变过程中,三个重要的细胞应激和氧化还原活性蛋白包括14-3-3α/β、谷胱甘肽转移酶(GST)和热休克蛋白(HSP70)参与致病。     

基于零部件归并问题的采购策略模型

针对不同价格和不同质量要求的 2种功能可互换的零部件 ,提出了一个研究零部件归并问题的数学模型 .在对零部件质量要求不同而供应商根据购买量提供的折扣不同的情形下 ,该模型可以帮助采购经理决定如何将零部件归并后统一购买以使得总购置成本最低 .     

高校多校区办学教学管理模式探析

随着我国高等教育管理体制改革的逐步推进,很多高校正在进行着“一校多区”的实践。文章先对国外多校区办学的成功管理经验作了介绍,接着对目前国内多校区办学采用的教学管理模式进行分析比较,最后提出构建多校区办学教学管理模式应着重考虑的若干问题。     

席慕蓉作品中的禅意

席慕蓉的作品有一个共同的特色：感悟人生、感悟爱情、感悟生命。正是这“感悟”二字,使我们可以从她的作品中体味到浓浓的禅的意味。     

建构主义视野下的大学文科实验教学实践——以网络新闻实务为例

建构主义学习理论为传统文科教学范式的转型提供了可资借鉴的解决方案与方法策略。论文以网络新闻实务实验教学为例,分别从情境构建、学习社区交流以及教学与学习评价几个方面进行了论述。     

Associations of Warmth and Control of Filipina Domestic Helpers and Mothers to Hong Kong Kindergarten Children's Social Competence

Research Findings: Across 63 Hong Kong families, both Filipina domestic helpers and mothers separately rated their own caregiving style (warmth and control) and kindergarten children's social competence. Results indicated that Filipina helpers rated themselves as higher in warmth than mothers did. In addition, self-rated warmth of both caregivers, and Filipina domestic helpers' self-perceived control were correlated with children's social competence. With ratings of warmth and control from both Filipina helpers and mothers included in separate regression equations, mothers' warmth was a strong unique correlate of all measures of children's social competence. However, Filipinas' warmth was uniquely associated with children's responsibility only, whereas their control was uniquely associated with children's assertion and responsibility. Practice or Policy: Results extend previous research on the importance of nonparental caregivers for children's social development in a new cultural context.     

Doing Good and Feeling Good: The Experiences of Older Volunteers in a University Research Registry

This paper reports the findings from a study that explored the experiential knowledge of older volunteers who participated in university research projects. Findings suggest that most participants were very positive about their experiences, and they appreciated the opportunity to contribute to research into ageing issues. In terms of areas of improvement, many highlighted the need for researchers to provide feedback on research outcomes and to consider access and transport issues. The capacity for critical reflection amongst participants suggests the potential for the development of more responsive research as well as for cultivating partnerships with older people in future research activities.