Accurate fundamental invariant-neural network representation of ab initio potential energy surfaces

Highly accurate potential energy surfaces are critically important for chemical reaction dynamics. The large number of degrees of freedom and the intricate symmetry adaption pose a big challenge to accurately representing potential energy surfaces(PESs) for polyatomic reactions. Recently, our group has made substantial progress in this direction by developing the fundamental invariant-neural network(FI-NN)approach. Here, we review these advances, demonstrating that the FI-NN approach can represe...     

Burden sharing for CDR: balancing fair liability with feasibility

<正>The basics are clear:climate is changing,it is caused by human activity and it is affecting everyone and everywhere now[1]. The good news is that we know what to do about it—we can stop global temperatures rising further if we stop emitting greenhouse gases. But because some sectors (such as agriculture or aviation)will have ongoing ‘hard-to-abate’ emissions,     

A neuron-immune circuit regulates neurodegeneration in the hindbrain and spinal cord of Arf1-ablated mice

Neuroimmune connections have been revealed to play a central role in neurodegenerative diseases(NDs).However, the mechanisms that link the central nervous system(CNS) and peripheral immune cells are still mostly unknown. We recently found that specific ablation of the Arf1 gene in hindbrain and spinal cord neurons promoted NDs through activating the NLRP3 inflammasome in microglia via peroxided lipids and adenosine triphosphate(ATP) releasing. Here, we demonstrate that IL-1β with elevated chemok...     

The temporal dynamics of antimicrobial-resistant Salmonella enterica and predominant serovars in China

Salmonella enterica is one of the most common bacterial pathogens in humans and animals.Systematic studies on the trends and geographical distribution of antimicrobial-resistant Salmonella and dominant serovars have been well studied in European and American countries while not in China.Here,taking the One-Health strategy,we used>35 000 Salmonella enterica isolates to explore the temporal and spatial dynamics of dominant serovars in China.We found that Salmonella Typhimurium was the dominant ...     

Glacial expansion of cold-tolerant species in low latitudes: megafossil evidence and species distribution modellingOA

<正>The Pleistocene was a time of repeated glaciations that severely affected the land biota over large areas of Eurasia and North America. Drastic climatic fluctuations during the Pleistocene drove largescale extinctions, migrations and diversification in plant and animal populations.These dramatic processes had a strong impact on the distribution of modern flora and fauna.     

我在马来西亚看到的羽毛球

这里是马来西亚紫色联盟最著名的俱乐部——八打灵羽毛球娱乐部,日本队首次拿到汤姆斯杯的功臣田児贤一退役后,也加盟到这里,做教练兼球员。我也不知道他吃了什么,居然胖成这样,人很nice,只是他一口马来口音的英语让我有点儿猝不及防。俱乐部楼道墙上挂起来的比赛服见证了俱乐部的发展,如果说都认识,这一定是暴露年龄的行为了。     

Association of daily sitting time and leisure-time physical activity with body fat among U.S. adults

Background:Prolonged sitting and reduced physical activity lead to low energy expenditures.However,little is known about the joint impact of daily sitting time and physical activity on body fat distribution.We investigated the independent and joint associations of daily sitting time and physical activity with body fat among adults.Methods:This was a cross-sectional analysis of U.S.nationally representative data from the National Health and Nutrition Examination Survey2011-2018 among adults aged ...     

Epidemiology of insertional and midportion Achilles tendinopathy in runners:A prospective cohort study

Background:Achilles tendinopathy(AT) is a common problem among runners.There is only limited evidence for risk factors for AT,and most studies have not defined the AT subcategories.No study has compared the incidence and risk factors between insertional AT and midportion AT,though they are considered distinct.This study aimed to assess incidence and risk factors of AT based on data from a large prospective cohort.The secondary aim was to explore differences in risk factors between insertional an...     

流光溢彩两千年

<正>璀璨花灯“一园灯火从天降,万片珊瑚驾海来。”花灯,又名灯笼、彩灯、灯彩,是起源于中国的一种汉族传统民俗工艺品。在古代,花灯的主要作用是照明,外皮由纸或绢制作,骨架用竹条或木条制作,灯内放上蜡烛或灯盏,点亮便可照明。到了春节、元宵、中秋等节日,精美的花灯又被赋予为佳节增光添彩,祈求平安的美好寓意。