教师素质测评研究报告及自我评价

通过对教师素质不同群体特异指标的量化研究 ,提出教师素质二元测评模式 ;利用统计学方法论证了其科学性 ;在管理工作中做了初步应用 ;最后以选题、方法论等方法做了评价 ,指出后继研究方向     

Immortalization of human umbilical vein endothelial cells with telomerase reverse transcriptase and simian virus 40 large T antigen

Objective: To establish normally conditionally-immortalized human umbilical vein endothelial cells (HUVECs) by ectopic expression of the human telomerase catalytic enzyme (hTERT) and simian virus 40 large T (SV40 LT) antigen. Methods: Primary HUVECs were transfected with recombinant retrovirus containing hTERT or SV40 LT respectively. Subsequently drug resistant cell clones were screened and expanded for further studies. Endothelial cell biomarkers were confirmed by examination. Results: The morphological phenotype of the transfected cells was similar to the non-transfected cells. Von Willebrand factor, hTERT and SV40 LT could be detected in transfected HUVECs. Moreover, higher telomerase activity in transfected cells was maintained for over 50 population doublings compared with only low level of endogenous telomerase transiently at early population doublings in primary HUVECs. When exposed to TNF-α(tumor necrosis factor-α), the expression of E-selectin in transfected cells was significantly up-regulated, but no alteration of endothelial lipase was found. Conclusion: Ectopic coexpression of hTERT and SV40 LT can effectively immortalize HUVECs without tumorigenicity in vitro. Immortalized HUVECs may be an ideal target of further molecular function studies.     

数字资源组织与数据挖掘之间关系探究

本文在比较数字资源组织及数据挖掘基本涵义的基础上，简要概括了二者在基础条件、终极目标等方面的相同点，并深入分析二者在理论基础、目的、侧重点、数据处理过程等方面的不同。     

图书馆宣传之软肋——世界读书日随感

本文将今年世界读书日前后出版发行的4种专业报纸标题中带有"图书馆"的新闻报道粗线条浅析,提出了图书馆宣传应加大力度的建议。     

The potential of transnational language policy to promote social inclusion of immigrants: An analysis and evaluation of the European Union’s INCLUDE project

Language issues and social inclusion consistently remain two major concerns for member countries of the European Union (EU). Despite an increasing awareness of the importance of language learning in migrants’ social inclusion, and the promotion of language policies at European and national levels, there is still a lack of common actions at the European level. Challenged by questions as to whether language learning should be prioritised as a human right or as human capital building, how host/mainstream language learning can be reinforced while respecting language diversity, and other problems, member countries still need to find solutions. Confronting these dilemmas, this study analyses the relationship and interactions between language learning and immigrants’ social inclusion in different contexts. It explores the potential of enhancing the effectiveness of language policies via a dialogue between policies and practices in different national contexts and research studies in the field of language and social inclusion. The research data are derived from two databases created by a European policy for active social inclusion project called INCLUDE. This project ran from 2013 to 2016 under the EU’s lifelong learning programme, with funding support from the European Commission. Through an analysis of these two project databases, the paper reviews recent national language policies and their effect on the social inclusion of migrants. In the second part of her article, the author interprets the process of language learning and social inclusion using poststructuralist theories of language and identity.     

从"别琴英语"到"中国英语"--英语在中国"本土化"的百年历程

英语的全球化必然带来英语的“本土化“.“别琴英语“(Pidgin English)和“中国英语“(China English)就是英语在中国本土化过程中的产物.本文试从历史以及语言文化的角度对英语在中国本土化的百年历程进行审视和分析,并就英语在当代中国的发展前景进行了展望.     

对医学生素质教育的探讨

为了更好地开展素质教育,我们对医学生素质现状、医学教学模式与教师知识结构状况进行了调查分析,并针对学生素质方面存在的问题提出了加强素质教育的具体措施。     

镗削斜孔的专用可调夹具的结构设计

成组夹具是专门为成组工艺中的一组相似性很强的零件而设计的。针对与钢板表面成小于90°斜孔的镗削加工,设计了一种专用可调的夹具,调整夹具的可调定位板螺钉中心距实现工件上孔的不同角度。该结构有效缩短了制造周期,提高了生产效率。     

Inhibitory mechanism of angiotensin-converting enzyme inhibitory peptides from black tea

The aim of this work is to discover the inhibitory mechanism of tea peptides and to analyse the affinities between the peptides and the angiotensin-converting enzyme(ACE) as well as the stability of the complexes using in vitro and in silico methods. Four peptide sequences identified from tea, namely peptides I, II, III, and IV, were used to examine ACE inhibition and kinetics. The half maximal inhibitory concentration(IC_(50)) values of the four peptides were(210.03±18.29),(178.91±5.18),(196.31±2.87), and(121.11±3.38) μmol/L, respectively. The results of Lineweaver-Burk plots showed that peptides I, II, and IV inhibited ACE activity in an uncompetitive manner, which requires the presence of substrate. Peptide III inhibited ACE in a noncompetitive manner, for which the presence of substrate is not necessary. The docking simulations showed that the four peptides did not bind to the active sites of ACE, indicating that the four peptides are allosteric inhibitors. The binding free energies calculated from molecular dynamic(MD) simulation were-72.47,-42.20,-52.10, and-67.14 kcal/mol(1 kcal=4.186 kJ),r espectively. The lower IC_(50) value of peptide IV may be attributed to its stability when docking with ACE and changes in the flexibility and unfolding of ACE. These four bioactive peptides with ACE inhibitory ability can be incorporated into novel functional ingredients of black tea.     

科研过程、科研能力以及科研训练的特征分析

科研和科研训练是研究生教育特别是博士教育阶段的重要功能．对其过程和特征进行分析对于推进研究生教育实践,提高研究生培养质量都具有积极的意义。科研过程由于其知识对象具有专业化、前沿性及综合性的特征,相应地也具有专业性、探索性、批判反思性的特征。科研能力可以大致分为认知能力或者说心智水平、实践操作技能和缄默知识三种类型。科研训练必须在实际的研究过程中训练,在具体的学术环境中潜移默化,同时科研训练的规训特征也要求训练程序的严格性和程序性。