Proteomic analysis of human umbilical vein endothelial cells exposed to PM<Subscript>2.5</Subscript>

Exposure to fine ambient particulate matter (PM_2.5) is known to be associated with cardiovascular disease. To uncover the molecular mechanisms involved in cardiovascular toxicity of PM_2.5, we investigated alterations in the protein profile of human umbilical vein endothelial cells (HUVECs) treated with PM_2.5 using two-dimensional electrophoresis in conjunction with mass spectrometry (MS). A total of 31 protein spots were selected as differentially expressed proteins and identified by matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) MS. The results demonstrated that DNA damage and cell apoptosis are important factors contributing to PM_2.5-mediated toxicity in HUVECs. It is further proposed that PM_2.5 can inhibit superoxide dismutase (SOD) activity and increase reactive oxygen species (ROS) and malonaldehyde (MDA) production in a concentration-dependent manner. Induction of apoptosis and DNA damage through oxidative stress pathways may be one of the key toxicological events occurring in HUVECs under PM_2.5 stress. These results indicated that the toxic mechanisms of PM_2.5 on cardiovascular disease are related to endothelial dysfunction.     

语文课程的文化变迁与价值重构

在语文课程的发展历史上,"应用"说一直占据着主导地位.它抹杀了语文课程丰厚的文化蕴涵和独特的人文价值,导致语文教育的平庸化、世俗化走向.其实,语文不仅是"应用"(应生活之用)之学,更是"应需"(应生命存在与表现之需)之学,"成人"、"立人"才是语文教育的本质与追求.同时,语文课程还要承担社会责任,以文化主体身份积极参与并推进社会文化建设.     

Heat transfer characteristics of air cross-flow for in-line arrangement of spirally corrugated tube and smooth tube bundles

An experimental study on heat transfer and resistance coefficients of linearly arranged smooth and spirally corrugated tube bundles in cross-flow was performed. The heat transfer and resistance coefficients are presented in this paper with transverse and longitudinal tube-pitch and tube geometries taken into account. The experiment's results can provide technical guidelines for application to horizontal air preheater with arranged in-line spirally corrugated tube bundles, especially to the air preheater for CFBCBs (Circulating Fluidized Bed Combustion Boilers).     

发展与稳定：考试政策行政功能分析

考试作为一种测度、甄别、评价人的素质水平的社会活动,具有社会稳定功能。考试的社会稳定功能可能是积极的、有利于社会发展的；也可能不是积极的,不利于社会发展的。考试政策的社会稳定功能必须以社会发展功能为前提,应坚持为了发展的稳定,不能为了稳定而牺牲发展,这样才能实现考试政策行政功能的合理张力。     

Mathematical Model of Weight in Evaluation System

ＭａｔｈｅｍａｔｉｃａｌＭｏｄｅｌｏｆＷｅｉｇｈｔｉｎＥｖａｌｕａｔｉｏｎＳｙｓｔｅｍＳｕｎＬｕ（孙璐）ＤｅｎｇＸｕｅｊｕｎ（邓学钧）（ＴｒａｎｓｐｏｒｔａｔｉｏｎＣｏｌｅｇｅ，ＳｏｕｔｈｅａｓｔＵｎｉｖｅｒｓｉｔｙ，Ｎａｎｊｉｎｇ２１００１８）Ａ...     

运动表象训练在高校女生跨栏教学中的运用与研究

根据运动心理学原理，针对普通高校女生在跨栏学习过程中产生的消极、恐惧等现象，将运动表象训练运用到女生跨栏教学中，使跨栏的基本知识、基本技术和基本技能的学习与智能训练相结合，改变了原来跨栏教学枯燥而紧张的教学结构。实验结果表明，其教学结果优于常规教学。     

开放教育教学方式的多样化

探索开放教育教学方式的多样化是开放教育教学模式改革的重要内容。开放教育教学方式的多样化 ,体现在小组教学分散化、授课教案公开化、电子邮件公共化、个别教学经常化、网络教学资源整合化等多方面     

基于组织变革的中小学校长培训及其关系处理研究

校长培训组织应该依据社会与教育发展所引起的培训环境的变化，及时调整和完善自身结构和功能，以满足校长培训发展的新需要，这是一种新的搞好“十一五”中小学校长培训工作的组织变革观。文章认为。在实现培训组织变革中，要慎重处理好正规与非正规、现代培训手段与传统培训方式等六大关系。     

弱相关模型中的分块拟回归

为了减少计算复杂性,在计算机试验设计中,最近人们提出了一种新的统计方法--拟回归Owen(2000),An and Owen(2001)).在独立同分布模型中,拟回归不仅能提高计算速度,而且有较好的统计性质.然而,对相关数据模型,这种方法的统计性质并不好.针对这一问题,在不增加计算复杂性的条件下,本文提出一种分块拟回归方法.我们研究分块拟回归的小样本和大样本性质,如无偏性、均方收敛性.强收敛性和渐近正态性.结果表明分块拟回归比原拟回归渐近有效.本文还讨论了曲线拟合的性质,指出了分块拟回归(包括原拟回归)在高维问题中的缺陷,为改善曲线拟合,我们还提出一种修正分块拟回归.研究表明,在高维问题中,修正分块拟回归是十分有效的.     

略论20世纪80年代马原小说的叙事艺术

该文从质疑小说故事的真实性入手,着重探讨了20世纪80年代马原小说创作中的叙事艺术:用表达印象代替塑造人物和叙述情节;用强化叙事形式模糊故事内容的完整性.