Pancreatic somatostatinoma with obscure inhibitory syndrome and mixed pathological pattern

Somatostatinoma is a very rare neuroendocrine tumor that originates from D cells and accounts for less than 1% of all gastrointestinal endocrine tumors. The duodenum is the most frequent site for this tumor, followed by the pancreas. We here describe a 46-year-old Chinese woman who developed pancreatic somatostatinoma presenting with the characteristic “inhibitory” syndrome, but the symptoms were obscure and seemingly uncorrelated. This case is also unique for its large tumor size and mixed pathological pattern. Distal pancreatectomy was performed, and the patient has remained well since operation. As the syndromes of somatostatinoma may be obscure and atypical, clinicians should review all clinical findings to obtain an accurate diagnosis. Aggressive surgery is preferred to improve the survival.     

Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/Akt and ERK1/2 pathways

Mesenchymal stem cell(MSC)transplantation has shown a therapeutic potential to repair the ischemic and infracted myocardium,but the effects are limited by the apoptosis and loss of donor cells in host cardiac microenvironment.The aim of this study is to explore the cytoprotection of heat shock protein 90(Hsp90)against hypoxia and serum deprivation-induced apoptosis and the possible mechanisms in rat MSCs.Cell viability was determined by3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay.Apoptosis was assessed by Hoechst 33258nuclear staining and flow cytometric analysis with annexin V/PI staining.The gene expression of Toll-like receptor-4(TLR-4)and V-erb-b2 erythroblastic leukemia viral oncogene homolog 2(ErbB2)was detected by real-time polymerase chain reaction(PCR).The protein levels of cleaved caspase-3,Bcl-2,Bcl-xL,Bax,total-ERK,phospho-ERK,totaI-Akt,phospho-Akt,and Hsp90 were detected by Western blot.The production of nitric oxide was measured by spectrophotometric assay.Hsp90 improves MSC viability and protects MSCs against apoptosis induced by serum deprivation and hypoxia.The protective role of Hsp90 not only elevates Bcl-2/Bax and Bcl-xL/Bax expression and attenuates cleaved caspase-3 expression via down-regulating membrane TLR-4 and ErbB2 receptors and then activating their downstream PI3K/Akt and ERK1/2 pathways,but also enhances the paracrine effect of MSCs.These findings demonstrated a novel and effective treatment strategy against MSC apoptosis in cell transplantation.     

通用彝文信息化字库建设

在彝语六大方言基础上,按固定字形、字义,各按方言念读的原则,整理出滇川黔桂四省区皆能使用的通用彝文字形,结合TrueType技术设计出独具特色的彝文字体,以此建立通用彝文信息化字库。     

邓小平解放思想、实事求是的思想探析

解放思想、实事求是,是马列主义、毛泽东思想的精髓,也是邓小平理论的精髓。解放思想、实事求是的思想路线对我们社会主义现代化建设有着极为重要的作用。     

通过对照实验的设计培养学生探究能力

生物学是一门以实验为基础的自然科学,生物实验教学的基本思想之一是通过对照来研究和揭示研究对象的某种属性。生物教师应从科学的认识方法论的角度,通过优化设计并安排一系列有针对性的实验,引导学生思维,培养学生的探究能力。     

浅谈电大工程数学中的古典概型教学

概率是电大开放教育工程数学中的一项重要教学内容。概率是在古典概型的基础上发展起来的,古典概型在概率中占有相当重要的地位,在社会生产、生活中及理论研究中有着重要的应用。作者结合几年来的教学实践谈谈对工程数学中古典概型教学的一些做法和体会。     

高校来华留学生的教育满意度测评——以江西省为例

通过对江西省高校来华留学生问卷调查和个案访谈资料,从办学条件、教学状况、自我发展、后勤保障、管理服务与收费5个层面对高校来华留学生的教育满意度进行测评。研究结果显示,江西省来华留学生的教育满意度较高,来华留学教育的优势明显,学校办学条件较好,留学生留学收获较大,学费、住宿费和生活费较低,但也存在一些不足。高校应充分发挥来华留学教育的优势,打造品牌,形成特色,把来华留学教育事业做大做强。     

Cross-cultural influence on communication effectiveness and user interface design

The objective of this study was to investigate the impact of cultural diversity on communication effectiveness with different communication styles and to apply the results in the field of user interface design for computer-based communication systems. The scope of this study was limited to the relationship between context and verbal/nonverbal communication, and also the relationship between power distance and communication interaction. The results indicated that high context people (HCP) had better communication effectiveness in comprehending nonverbal clues than low context people (LCP), while LCP had better communication effectiveness in verbal communication than their counterparts. It was also found that high power distance people (HPDP) could not communicate as effectively as low power distance people (LPDP) during communication with interaction, but there was no significant difference between HPDP and LPDP in dealing with communication without interaction.     

论当代大体育观的形成与建立

世界大生产、大经济和大科学的形成，对大体育观的形成产生一定的影响。大体育观认为，体育是一个多层次、开放、综合的大系统，是具有科学内容的多结构与多功能的全周期、全身心、全民族的体育。     

整理活动方式对消除运动员运动后血乳酸效果的分析

采用实验法，比较安静休息、轻松整理活动和专项整理活动方式对运动后血乳酸的清除、消除心理疲劳的效果。结果发现：积极性的整理活动效果明显优于安静休息；轻松整理活动和专项整理活动对血乳酸的清除效果无显著性差异，但轻松整理活动对消除心理疲劳的效果优于专项整理活动。