A Laboratory-intensive Course on RNA Interference and Model Organisms

RNA interference (RNAi) is a powerful method to silence gene expression in a variety of organisms and is generating interest not only as a useful tool for research scientists but also as a novel class of therapeutics in clinical trials. Here, we report that undergraduate and graduate students with a basic molecular biology background were able to demonstrate conceptual knowledge and technical skills for using RNAi as a research tool upon completion of an intensive 8-wk RNAi course with a 2-h lecture and 5-h laboratory per week. Students were instructed on design of RNAi experiments in model organisms and perform multiweek laboratory sessions based on journal articles read and discussed in class. Using Nicotiana benthamiana, Caenorhabditis elegans, and mammalian cell culture, students analyzed the extent of silencing using both qualitative assessment of phenotypic variations and quantitative measurements of RNA levels or protein levels. We evaluated the course over two semesters, each with a separate instructor. In both semesters, we show students met expected learning outcomes as demonstrated by successful laboratory experiment results, as well as positive instructor assessments of exams and lab reports. Student self-assessments revealed increased confidence in conceptual knowledge and practical skills. Our data also suggest that the course is adaptable to different instructors with varying expertise.     

“We’re Here to Learn to Speak French”: An Exploration of World Language Teachers’ Beliefs About Students and Teaching

The purpose of this qualitative study was to explore five world language teachers’ beliefs about their students, their attributions about student enrollment, and their reported teaching practices. Findings represent a continuum of critical practice in that three teachers appeared to espouse deficit thinking and stereotypes about students of color, and color-evasiveness or colorblindness as an approach to teaching. Two teachers appeared to espouse beliefs that may be more representative of inclusive classrooms, and these teachers reported advocacy work for certain student groups and efforts to develop students’ critical consciousness in their classrooms. Findings are contextualized via critical lenses, and implications for language teacher education and policy are discussed.     

Organizing for survival and social change: The case of streetwise

This study explores how members of StreetWise organize for survival and social change. Through the publication of a street journal by the same name, StreetWise provides employment opportunities for men and women without homes. Using feminist principles of organizing as a backdrop, we highlight the discursive moves that (1) reinforce StreetWise's standpoint as counter to the practices and structures of the dominant culture, and (2) provide alternative ways of thinking about issues of poverty and homelessness. We highlight tensions that emerge between the dialectic of survival and social change, and in so doing position StreetWise as an “alternative discourse community” that develops counterdiscourses amidst cultural and material constraints. We work toward locating how members negotiate organizational irrationalities through moral deliberation.     

Managing the Research University: Clark Kerr and the University of California

In the 1950s and 1960s, Clark Kerr led the University of California's Berkeley campus, and then the University of California as a whole. Throughout these years, he developed a system of managerial strategies. This paper shows how Kerr's administrative views drew upon his background in industrial relations, his liberal theories of pluralistic industrial change, and contemporary understandings of American business organization.     

Introducing Argumentation About Climate Change Socioscientific Issues in a Disadvantaged School

Research in Science Education - Improving the ability of young people to construct arguments about controversial science topics is a desired outcome of science education. The purpose of this...     

A Taxonomy of Knowledge Types for Use in Curriculum Design

This article proposes the use of a taxonomy to help curriculum planners distinguish between different kinds of knowledge. Nine categories are suggested: empirical, rational, conventional, conceptual, cognitive process skills, psychomotor, affective, narrative, and received. Analyzing lessons into the sources of their resident knowledge helps the teacher proceed in a less dogmatic manner, distinguishing between categories of knowledge based upon where that knowledge originates. This taxonomy facilitates a meta-narrative on the nature of knowledge — how it is discovered, invented, decided upon, and so on — and the form that it takes in human experience and learning.     

The impact of making-weight on cognitive performance in apprentice jockeys

Jockeys regularly engage in rapid weight-loss practices in preparation for competition. These practices are thought to impair cognitive function, although the evidence in support of this theory remains inconclusive. The purpose of this study was to examine the effects of making-weight on cognitive function in apprentice jockeys in a simulated and competitive environment. Apprentice jockeys (n = 12) reduced their body mass by 4% in 48 h in a simulated environment using weight-loss methods typically adopted in preparation for racing. Simple and choice reaction time, attention, learning and memory were assessed before and after the weight loss. A further 10 apprentice jockeys performed the cognitive function assessment in a competitive racing environment at both a self-reported “normal” and “light” body mass. Hydration status and body mass were assessed in all trials. In the simulated environment, body mass was reduced by 4.2 ± 0.3%, yet no change in cognitive function was observed. Cognitive function also remained unchanged in the competitive environment after a body mass loss of 5.7 ± 1.9%. Typical reductions in body mass in preparation for racing have no effect on cognitive function in apprentice jockeys in a simulated and competitive environment. Further research is required to investigate the physiological mechanisms preventing the adverse effects of making-weight on cognitive function in jockeys.     

New library buildings. Part VI: Sciences Library, Brown University.

Brown was one of the first universities in the nation to combine its science collections into a single library in the interest of aiding interdisciplinary teaching and research. This paper discusses the evolution of the Sciences Library and its resources, the development of the medical education program, and the physical aspects of the new library building. A fifteen-story tower, housing the collections of the physical, biological, and medical sciences, symbolizes the interdisciplinary approach to teaching and research at Brown University.     

Where would formal, academic mathematics stand in a curriculum informed by ethnomathematics? A critical review of ethnomathematics

This paper is a critical review of the ethnomathematics literature and classifies ethnomathematics according to where it might stand in relation to the teaching of formal, academic mathematics. This paper investigates what it sees as four possibilities: ethnomathematics should replace academic mathematics, ethnomathematics should be a supplement to the mathematics curriculum, ethnomathematics should be used as a springboard for academic mathematics and ethnomathematics should be taken into consideration when preparing learning situations. We argue that it is only through the lens of formal, academic mathematics sensitive to cultural differences that the real value of the mathematics inherent in certain cultures and societies be understood and appreciated.This revised version was published online in October 2005 with corrections to the Cover Date.