Rediscovering Development in Infancy

This commentary endorses J. Kagan’s (2008) conclusion that many of the most dramatic findings on early perceptual, cognitive, and social competencies are ambiguous. It supports his call for converging research operations to disambiguate findings from single paradigms and single response indices. The commentary also argues that early competencies must be placed into a longitudinal framework, thereby allowing researchers to (a) identify whether regressive phenomena play a role in skill development, (b) understand what functions (if any) given skills play in their precocious manifestations and whether these functions are comparable in later instantiations of skills, and (c) avoid rich interpretations by identifying how robust a suspected competency is across contexts.     

Facial patterning and infant emotional expression: happiness, surprise, and fear

Although recent studies have convincingly demonstrated that emotional expressions can be judged reliably from actor-posed facial displays, there exists little evidence that facial expressions in lifelike settings are similar to actor-posed displays, are reliable across situations designed to elicit the same emotion, or provide sufficient information to mediate consistent emotion judgments by raters. The present study therefore investigated these issues as they related to the emotions of happiness, surprise, and fear. 27 infants between 10 and 12 months of age (when emotion masking is not likely to confound results) were tested in 2 situations designed to elicit hapiness (peek-a-boo game and a collapsing toy), 2 to elicit surprise (a toy-switch and a vanishing-object task), and 2 to elicit fear (the visual cliff and the approach of a stranger. Dependent variables included changes in 28 facial response components taken from previous work using actor poses, as well as judgments of the presence of 6 discrete emotions. In addition, instrumental behaviors were used to verify with other than facial expression responses whether the predicted emotion was elicited. In contrast to previous conclusions on the subject, we found that judges were able to make all facial expression judgments reliably, even in the absence of contextual information. Support was also obtained for at least some degree of specificity of facial component response patterns, especially for happiness and surprise. Emotion judgments by raters were found to be a function of the presence of discrete facial components predicted to be linked to those emotions. Finally, almost all situations elicited blends, rather than discrete emotions.     

Integrated and Predictive Systems for Preventive Conservation

ABSTRACT

Forecasting the dynamics of alteration in materials, in particular the timescale of degradation, is relevant to preventive conservation, and great deal of effort has gone into developing new models for the kinetics of physical and chemical phenomena affecting materials. Creating monitoring systems able to assess the evolution of degradation processes that inform intervention programs is necessary to ensure the protection of historical and artistic heritage. The Research Unit for Integrated and Predictive Systems (SIP) is presented: it develops new tools and algorithms to study the alteration of materials using non-invasive techniques and passive monitoring, as well as new mathematical models to predict how the surfaces of materials degrade with time. The paper focuses on the Arch of Augustus and presents initial results from two virtual sensors used to ‘monitor’ environmental conditions outdoors. These systems do not need a permanent, invasive network of sensors in situ. They rely instead on local infrastructure for measuring air quality, and adopt smart information fusion algorithms to predict the environment around the cultural heritage site. Virtual sensors can provide an effective control system that highlights specific conditions linked to specific forms of alteration.     

Domain Differences in Early Social Interactions

Different social experiences help children develop distinctions between domains of norms. This study investigated whether mothers respond differently to moral, prudential, and pragmatic norms during the 2nd year, a period that precedes the time when children are able to make explicit distinctions between these norms. Sixty mothers of infants between 11 and 23 months were interviewed. Mothers' reports of their initial interventions, changes in intervention following noncompliance, and emotional reactions depended on normative domain. Initial interventions were less differentiated by domain for mothers of older than for mothers of younger children. These findings suggest that children have social experiences in the 2nd year that are associated with distinctions among normative domains.     

Home Away from Home: Acclimatization of Filipino Elderly from being Home to a Sense of being “At Home” in an Elderly Institution

This grounded study examined the process of acclimatization or the process of changing perspectives of a person so as to get used to or feel “at home” among a select group of Filipino elderly in a nursing care facility. As institutionalization of the elderly is not typical in the Philippine context, varied responses were analyzed to understand the factors and the course that an elderly person undergoes over a set period of time to achieve acclimatization. Twenty elderly (n = 20) residents were purposively recruited and subjected to an in-depth interview that chronicled their experiences on their previous and present lives and on the process by which they were able to adjust to a relatively new setting. Preliminarily, a robotfoto was devised to obtain demographic data including visitation frequencies and familial relationships, and this was followed by an in-depth interview. Through the constant comparison method, an interesting model called the Hourglass of Acclimatization emerged. This model yielded two distinct phases contributing to successful acclimatization. One is the Conversion phase, or imbibing the main notion of transforming one's perspectives of him or herself and his or her environment; there is also the Immersion phase, which describes how an elderly involves him or herself completely into the life he or she is supposed to live. This emerged model can contribute to the development of nursing interventions focusing on elderly experiences in the entire course of relocation to a new environment other than what they call “home.”     

Contrast agent-free sonoporation: The use of an ultrasonic standing wave microfluidic system for the delivery of pharmaceutical agents

Sonoporation is a useful biophysical mechanism for facilitating the transmembrane delivery of therapeutic agents from the extracellular to the intracellular milieu. Conventionally, sonoporation is carried out in the presence of ultrasound contrast agents, which are known to greatly enhance transient poration of biological cell membranes. However, in vivo contrast agents have been observed to induce capillary rupture and haemorrhage due to endothelial cell damage and to greatly increase the potential for cell lysis in vitro. Here, we demonstrate sonoporation of cardiac myoblasts in the absence of contrast agent (CA-free sonoporation) using a low-cost ultrasound-microfluidic device. Within this device an ultrasonic standing wave was generated, allowing control over the position of the cells and the strength of the acoustic radiation forces. Real-time single-cell analysis and retrospective post-sonication analysis of insonated cardiac myoblasts showed that CA-free sonoporation induced transmembrane transfer of fluorescent probes (CMFDA and FITC-dextran) and that different mechanisms potentially contribute to membrane poration in the presence of an ultrasonic wave. Additionally, to the best of our knowledge, we have shown for the first time that sonoporation induces increased cell cytotoxicity as a consequence of CA-free ultrasound-facilitated uptake of pharmaceutical agents (doxorubicin, luteolin, and apigenin). The US-microfluidic device designed here provides an in vitro alternative to expensive and controversial in vivo models used for early stage drug discovery, and drug delivery programs and toxicity measurements.