A new approach to explore the knowledge transition path in the evolution of science & technology: From the biology of restriction enzymes to their application in biotechnology

In this contribution, we develop a new approach to explore the process of knowledge transition from discovery-oriented science to technological fields, via applications-oriented research, including a mediator set. This trajectory is referred to as the D-A-T trajectory. It is shown how it can be constructed and measures are proposed to characterize the relational strength among different environments (discovery oriented research, applications-oriented research and patents) and the speed of evolution. Our approach is illustrated by a case study of three fundamental restriction enzymes articles. Among other results we found that 387 patents cited 124 of the 988 articles (a share of 12.55%) in the mediator set. Defining the non-patent references (NPR) transition rate as the number of citing patents divided by the number of articles in the mediator set yields a value 0.392. Our results suggest that the D-A-T path acts as a backbone and reveals important “invisible contributions” of an original scientific work during its evolution from discovery oriented research to outside academia. Our contribution provides a useful tool for bridging the existing gap in detecting the transition of knowledge between science and technology.     

Neuroanatomy Learning: Augmented Reality vs. Cross-Sections

Neuroanatomy education is a challenging field which could benefit from modern innovations, such as augmented reality (AR) applications. This study investigates the differences on test scores, cognitive load, and motivation after neuroanatomy learning using AR applications or using cross-sections of the brain. Prior to two practical assignments, a pretest (extended matching questions, double-choice questions and a test on cross-sectional anatomy) and a mental rotation test (MRT) were completed. Sex and MRT scores were used to stratify students over the two groups. The two practical assignments were designed to study (1) general brain anatomy and (2) subcortical structures. Subsequently, participants completed a posttest similar to the pretest and a motivational questionnaire. Finally, a focus group interview was conducted to appraise participants’ perceptions. Medical and biomedical students (n = 31); 19 males (61.3%) and 12 females (38.7%), mean age 19.2 ± 1.7 years participated in this experiment. Students who worked with cross-sections (n = 16) showed significantly more improvement on test scores than students who worked with GreyMapp-AR (P = 0.035) (n = 15). Further analysis showed that this difference was primarily caused by significant improvement on the cross-sectional questions. Students in the cross-section group, moreover, experienced a significantly higher germane (P = 0.009) and extraneous cognitive load (P = 0.016) than students in the GreyMapp-AR group. No significant differences were found in motivational scores. To conclude, this study suggests that AR applications can play a role in future anatomy education as an add-on educational tool, especially in learning three-dimensional relations of anatomical structures.     

Report on Day 2

Abstract

This is a ‘view from the coalface’ of someone who runs a large company responsible for the training of other member companies of the Group of which it forms a part. He gives examples from the day‐to‐day work of his company, and looks to the future of open and distance learning in the industrial world.     

The acute testosterone,growth hormone,cortisol and interleukin-6 response to 164-km road cycling in a hot environment

This study investigated the acute endocrine responses to a 164-km road cycling event in a hot environment. Thirty-four male experienced cyclists (49.1 ± 8.3 years, 86.8 ± 12.5 kg, 178.1 ± 5.1 cm) participating in a 164-km road cycling event were recruited. Blood samples were collected within 0.3–2.0 h before the start (PRE: ~0500–0700 h) and immediately following the ride (POST). Samples were analysed for testosterone, growth hormone (GH), cortisol and interleukin-6 (IL-6). The temperature and humidity during the event were 35.3 ± 4.9°C and 47.2 ± 14.0%, respectively. Based on the finishing time, results for the fastest (FAST, 305 ± 10 min) and the slowest (SLOW, 467 ± 31 min) quartiles were compared. At POST, testosterone concentration was significantly (P < 0.05) lower (PRE, 20.8 ± 8.6; POST, 18.2 ± 6.7 nmol · L^?1), while GH (PRE, 0.3 ± 0.1; POST, 2.3 ± 0.3 µg · L^?1), cortisol (PRE, 661 ± 165; POST, 1073 ± 260 nmol · L^?1) and IL-6 (PRE, 4.0 ± 3.4; POST, 22.4 ± 15.2 pg · mL^?1) concentrations were significantly higher than those at PRE. At POST, GH and cortisol were significantly higher for the FAST group than for the SLOW group (GH, 3.6 ± 2.0 and 1.0 ± 0.8 µg · L^?1; cortisol, 1187 ± 209 and 867 ± 215 nmol · L^?1). Participation in an ultra-endurance road cycling event in a hot environment induced significant acute changes in concentrations of circulating hormones, with a greater augmentation of GH and cortisol in those completing the ride fastest.     

Mediating effects of resistance training skill competency on health-related fitness and physical activity: the ATLAS cluster randomised controlled trial

The purpose of this study was to examine the mediating effect of resistance training skill competency on percentage of body fat, muscular fitness and physical activity among a sample of adolescent boys participating in a school-based obesity prevention intervention. Participants were 361 adolescent boys taking part in the Active Teen Leaders Avoiding Screen-time (ATLAS) cluster randomised controlled trial: a school-based program targeting the health behaviours of economically disadvantaged adolescent males considered “at-risk” of obesity. Body fat percentage (bioelectrical impedance), muscular fitness (hand grip dynamometry and push-ups), physical activity (accelerometry) and resistance training skill competency were assessed at baseline and post-intervention (i.e., 8 months). Three separate multi-level mediation models were analysed to investigate the potential mediating effects of resistance training skill competency on each of the study outcomes using a product-of-coefficients test. Analyses followed the intention-to-treat principle. The intervention had a significant impact on the resistance training skill competency of the boys, and improvements in skill competency significantly mediated the effect of the intervention on percentage of body fat and the combined muscular fitness score. No significant mediated effects were found for physical activity. Improving resistance training skill competency may be an effective strategy for achieving improvements in body composition and muscular fitness in adolescent boys.     

DIELECTRIC STUDIES OF UREASE AS A FUNCTION OF HYDRATION

The steady-state electrical conductivity,as well as the dielectric propertiesbetween 2×10~(-4)Hz and 100 kHz,and at 1 GHz,are reported for urease compressed powdersamples of low hydration.The results show that the large,low frequency dielectricdispersion,known as α-dispersion,is due to the build-up of a space charge of protons atthe sample-electrode interfaces.A smaller dispersion,appearing at higher frequencies,isconcluded to be associated with hindered motions of the peptide residues in the molecularstructure of urease.The extent of these polypeptide backbone motions is shown to bestrongly depended on the extent of enzyme hydration.This work is contributed to the de-velopment of conductimetric biosensors.     

Relationships of attitude toward classroom environment with attitude toward and achievement in science among tenth grade biology students

The purpose of the study was to examine the relationship of classroom environment to attitudes toward science and achievement in science among tenth grade biology students. An attitude instrument was administered at three times during the school year to measure student attitudes toward science and the classroom environment. The classroom environment measures examined six areas: emotional climate of the science classroom, science curriculum, physical environment of the science classroom, science teacher, other students in the science classroom, and friends attitudes toward science. Student achievement in science was measured by teacher reported semester grades. The results of the study indicated: (1) student attitudes toward the classroom environment predicted between 56 to 61% of the variance in attitudes toward science, (2) student attitudes toward the classroom environment predicted between 5 to 14% of the variance in achievement in science, (3) student attitudes toward science and attitudes toward the classroom environment predicted between 8 and 18% of the variance in achievement in science.     

The Roles of Parental Support and Family Stress in Adolescent Sleep

The current study examines the association between parental support and adolescent sleep under varying levels of family stress. Participants included 316 adolescents (M_age = 16.40 years, 43% male) and their parents (M_age = 45.67 years, 91% mothers) from diverse ethnic backgrounds. Both adolescents and parents completed questionnaires and adolescents wore wrist actigraphs and completed self‐reports on their sleep for 7 consecutive days. Results indicated that under contexts of family stress, more parental support was linked to longer sleep duration, less sleep variability, and less time spent awake during the night. Findings suggest that under contexts of family stress, cohesive family relationships may provide a sense of stability and security that is necessary for healthful sleep.