A neuron-immune circuit regulates neurodegeneration in the hindbrain and spinal cord of Arf1-ablated mice

Neuroimmune connections have been revealed to play a central role in neurodegenerative diseases(NDs).However, the mechanisms that link the central nervous system(CNS) and peripheral immune cells are still mostly unknown. We recently found that specific ablation of the Arf1 gene in hindbrain and spinal cord neurons promoted NDs through activating the NLRP3 inflammasome in microglia via peroxided lipids and adenosine triphosphate(ATP) releasing. Here, we demonstrate that IL-1β with elevated chemok...     

The temporal dynamics of antimicrobial-resistant Salmonella enterica and predominant serovars in China

Salmonella enterica is one of the most common bacterial pathogens in humans and animals.Systematic studies on the trends and geographical distribution of antimicrobial-resistant Salmonella and dominant serovars have been well studied in European and American countries while not in China.Here,taking the One-Health strategy,we used>35 000 Salmonella enterica isolates to explore the temporal and spatial dynamics of dominant serovars in China.We found that Salmonella Typhimurium was the dominant ...     

Glacial expansion of cold-tolerant species in low latitudes: megafossil evidence and species distribution modellingOA

<正>The Pleistocene was a time of repeated glaciations that severely affected the land biota over large areas of Eurasia and North America. Drastic climatic fluctuations during the Pleistocene drove largescale extinctions, migrations and diversification in plant and animal populations.These dramatic processes had a strong impact on the distribution of modern flora and fauna.     

我在马来西亚看到的羽毛球

这里是马来西亚紫色联盟最著名的俱乐部——八打灵羽毛球娱乐部,日本队首次拿到汤姆斯杯的功臣田児贤一退役后,也加盟到这里,做教练兼球员。我也不知道他吃了什么,居然胖成这样,人很nice,只是他一口马来口音的英语让我有点儿猝不及防。俱乐部楼道墙上挂起来的比赛服见证了俱乐部的发展,如果说都认识,这一定是暴露年龄的行为了。     

Association of daily sitting time and leisure-time physical activity with body fat among U.S. adults

Background:Prolonged sitting and reduced physical activity lead to low energy expenditures.However,little is known about the joint impact of daily sitting time and physical activity on body fat distribution.We investigated the independent and joint associations of daily sitting time and physical activity with body fat among adults.Methods:This was a cross-sectional analysis of U.S.nationally representative data from the National Health and Nutrition Examination Survey2011-2018 among adults aged ...     

Epidemiology of insertional and midportion Achilles tendinopathy in runners:A prospective cohort study

Background:Achilles tendinopathy(AT) is a common problem among runners.There is only limited evidence for risk factors for AT,and most studies have not defined the AT subcategories.No study has compared the incidence and risk factors between insertional AT and midportion AT,though they are considered distinct.This study aimed to assess incidence and risk factors of AT based on data from a large prospective cohort.The secondary aim was to explore differences in risk factors between insertional an...     

冷凝管内冷却水流动方向的解析

1 问题的提出 在室温下,有些反应速率很小或难于进行.为了使反应顺利地进行,常常需要使反应物质较长时间保持沸腾.这种情况就需要使用回流冷凝装置,使蒸气不断地在冷凝管内冷凝而返回反应器中,以防止反应瓶中的物质逃逸损失[1].     

意义学习分类学

综合十年的研究,作者描述了意义学习的一种分类办法.最有意义的学习结果是解决问题.在这种分类法中,四种不同的问题解决按层次方式排列.解决问题的先决条件是两种基本的推理技能——类比推理和因果推理,这是解决所有问题的基础.这些推理的形式要求运用概念,以及由概念和关系组成的低阶命题和高阶命题.解决问题的教学应该是让学习者解决问...     

中国玉米黄金产业大发展

新世纪10年（2000年～2010年）,中国玉米生产和玉米产业发展至历史最好水平,2010年玉米种植面积达到4．75亿亩（水稻4．40亿亩,冬小麦3．63亿亩）。最主要原因是政策好、天帮忙、好品种、用途广。     

商品个性标志的定义及其在美国流行文化中的角色

在过去的一个多世纪,商品的个性标志一直是美国人钟爱的广告工具。各种各样被广告商作为传播体系的＂会说话的动物＂和＂会跳舞的产品＂已悄无声息地蔓延在美国的流行文化中。1982年,有人在做调查后发现,凡是商品特征明显的广告,在改变品牌偏好的能力上要比同行业其他品牌强。这一点表明社会正在接收商品个性标志这样的讯息。然而,尽管商品个性标志的运用在广告商和消费者中大受欢迎,却几乎被完全遗忘在广告和流行文化研究的角落。本文将从相关文学的角度解析什么是商品个性标志,以及其如何运用在现代广告业中,并与消费者进行交流。