‘灿烂’品种兔眼蓝莓花青素提取物在体内的抗氧化活性（英文）

蓝莓富含花青素等酚类化合物,具有良好的保健功能。本研究旨在研究从‘灿烂’品种兔眼蓝莓中提取的蓝莓花青素在小鼠体内的抗氧化活性。C57BL/6J健康雄性小鼠被分成不同剂量组,各组蓝莓花青素提取物（BAE）浓度分别为100、400和800 mg/kg。在不同时间点（0.1、0.5、1、2、4、8和12 h）将小鼠处死,收集其血浆、眼球、肠、肝和脂肪组织,比较其抗氧化活性,测定指标包括总抗氧化能力（T-AOC）、超氧化物歧化酶（SOD）活性、谷胱甘肽过氧化物酶（GSH-PX/GPX）含量,以及氧化应激标志物丙二醛（MDA）水平。结果表明：蓝莓花青素在小鼠体内具有良好的抗氧化活性,并呈浓度依赖性,BAE浓度越高,T-AOC值越高,MDA水平越低。抗氧化酶SOD活性、GSH-PX含量以及Cu,Zn-SOD、Mn-SOD和GPX的m RNA水平均证实,BAE在小鼠消化后通过改善其抗氧化防御系统发挥抗氧化作用。蓝莓花青素提取物的体内抗氧化活性表明,蓝莓花青素可以被开发成功能性食品或营养配料,用于预防或治疗氧化应激相关的疾病。     

中俄跨境合作：未实现的历史机遇(二)

在俄罗斯国家漫长的历史进程中,对地理位置偏远、经济欠发达东部地区的开发利用始终是国家需要面对的现实问题,行之有效的方法之一便是跨境合作。许多拥有共同边界,但彼此并没有一体化责任的国家均把跨境合作的理念和实践作为国家发展的“武器”(手段)。无论是拥有共同边界,还是邻国的积极响应,这些因素都无法保证跨境合作取得成功,也无法保障边境地区经济发展取得成效。俄罗斯远东地区跨境合作的发展进程,关键在于中俄跨境合作。中俄边境跨境合作的最新状况是深入理解当代中俄关系和中俄边境合作的共同规律和发展特点的重要支点。中俄边境合作的主要发展趋势和特点表现为“从自然上升到有序衰落”的过程。形成这一过程的主要因素是俄罗斯政府对远东地区实行严格监管政策,并且通过对俄罗斯远东地区与周边国家跨境合作的中心化和集中化体现出来。     

Meeting guidelines for physical activity,muscle strength,and sleep lowers mortality risk:Commentary on: "Associations between aerobic and musclestrengthening physical activity,sleep duration,and risk of all-cause mortality:A prospective cohort study of 282

<正>In 2022, Duncan et al.¹ published results from an investigation of the combined effects of moderate-to-vigorous aerobic exercise(AER), muscle-strengthening activities(MSA), and sleep durations on the risks for all-cause mortality in 282,473 U.S. adults aged 18—84 years.     

Accurate fundamental invariant-neural network representation of ab initio potential energy surfaces

Highly accurate potential energy surfaces are critically important for chemical reaction dynamics. The large number of degrees of freedom and the intricate symmetry adaption pose a big challenge to accurately representing potential energy surfaces(PESs) for polyatomic reactions. Recently, our group has made substantial progress in this direction by developing the fundamental invariant-neural network(FI-NN)approach. Here, we review these advances, demonstrating that the FI-NN approach can represe...     

Burden sharing for CDR: balancing fair liability with feasibility

<正>The basics are clear:climate is changing,it is caused by human activity and it is affecting everyone and everywhere now[1]. The good news is that we know what to do about it—we can stop global temperatures rising further if we stop emitting greenhouse gases. But because some sectors (such as agriculture or aviation)will have ongoing ‘hard-to-abate’ emissions,     

A neuron-immune circuit regulates neurodegeneration in the hindbrain and spinal cord of Arf1-ablated mice

Neuroimmune connections have been revealed to play a central role in neurodegenerative diseases(NDs).However, the mechanisms that link the central nervous system(CNS) and peripheral immune cells are still mostly unknown. We recently found that specific ablation of the Arf1 gene in hindbrain and spinal cord neurons promoted NDs through activating the NLRP3 inflammasome in microglia via peroxided lipids and adenosine triphosphate(ATP) releasing. Here, we demonstrate that IL-1β with elevated chemok...     

Comparative orotomy of the Archean Superior and Phanerozoic Altaid orogenic systems

We compare and contrast the materials and mechanisms of continental crustal growth in the largest preserved regions of Phanerozoic and Archean juvenile additions to the crust,to test for similarities or differences in the formation of continents through time.We accomplish this through a comparison of map patterns,lithological contents,and structural and metamorphic evolution of the Phanerozoic Altaid orogenic system of Asia,with the Archean Superior Province of the North American Craton,using a ...     

The temporal dynamics of antimicrobial-resistant Salmonella enterica and predominant serovars in China

Salmonella enterica is one of the most common bacterial pathogens in humans and animals.Systematic studies on the trends and geographical distribution of antimicrobial-resistant Salmonella and dominant serovars have been well studied in European and American countries while not in China.Here,taking the One-Health strategy,we used>35 000 Salmonella enterica isolates to explore the temporal and spatial dynamics of dominant serovars in China.We found that Salmonella Typhimurium was the dominant ...     

Glacial expansion of cold-tolerant species in low latitudes: megafossil evidence and species distribution modellingOA

<正>The Pleistocene was a time of repeated glaciations that severely affected the land biota over large areas of Eurasia and North America. Drastic climatic fluctuations during the Pleistocene drove largescale extinctions, migrations and diversification in plant and animal populations.These dramatic processes had a strong impact on the distribution of modern flora and fauna.     

五位拳坛巨星的拳击哲学

拳击是一项很特别的运动。一方面,任何人都可以学习拳击。另一方面,只有极少数的人才能达到卓越的水平。立志要成为冠军的人,为了寻求技术上的提高,会日复一日在训练馆里挥汗如雨,同一个动作重复成千上万次,直到达到完美。从这个角度上来说,拳击能够帮你探测身体和意志上的极限。纵观拳击的历史,有许多已经到达巅峰的传奇人物。