Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension

Idiopathic pulmonary arterial hypertension(IPAH) is a rare disease of unknown etiology.The exact pathogenesis of pulmonary arterial hypertension is still not well known.In the past decades,many protein molecules have been found to be in-volved in the development of IPAH.With proteomic techniques,profiling of human plasma proteome becomes more feasible in searching for disease-related markers.In present study,we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum.Thirteen spots had changed significantly in IPAH com-pared with healthy controls and were identified by LC-MS/MS.Alpha-1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH.     

“金属工艺学”教学改革初探

就金属工艺学课多种形式相结合的教学方式进行了探讨。     

Orders of magnitude reasoning applied in selecting shield

ＯｒｄｅｒｓｏｆＭａｇｎｉｔｕｄｅＲｅａｓｏｎｉｎｇＡｐｐｌｉｅｄｉｎＳｅｌｅｃｔｉｎｇＳｈｉｅｌｄＹｕＺｈｏｎｇｙｕａｎＨｕＭｉｎ＊ＬｉｕＺｈｅｎｙｕ＊＊（ＳｈａｎｇｈａｉＴｉｅｄａｏＵｎｉｖｅｒｓｉｔｙ,＊ＳｈａｎｇｈａｉＵｎｉｖｅｒｓｉｔｙ,＊...     

Preparation of a novel biodegradable β-cyclodextrin-containing polymer

A novel cyclodextrin-containing polymer was prepared by graftingβ-cyclodextrin onto the backbone of poly(D,L-lactic acid)(PLA).First,mono(6-(2-aminoethyl)amino-6-deoxy)-β-cyclodextrin(β-CD-6-en)was prepared by sulfonylation and amination ofβ-cyclodextrin and modified poly(D,L-lactic acid)(MPLA)was prepared by free radical polymerization of maleic anhydride and PLA.Then,grafting ofβ-cyclodextrin derivative to MPLA backbone was carried out by N-acylation reaction of MPLA andβ-CD-6-en in dimethyl formamide.The...     

北京城市学院师资队伍现状调研报告

本调研报告是2005年5月学校教育科学研究课题立项《北京城市学院师资队伍建设与管理问题的研究》的主要成果。本报告在对学校师资队伍现状进行了全面、细致调研的基础上,对师资队伍的特点和主要问题进行了分析,并提出了相应的对策及建议。     

女性与继续教育

大力发展继续教育，提高劳动者的整体素质，成为我国当前用至今后很长一个时期需不断加强的工作，其中如何对待女性的继续教育更是值得研究的问题。     

Establishment of reference mandibular plane for anterior alveolar morphology evaluation using cone beam computed tomography

To propose a method of establishing the reference mandibular plane(MP),which could be reestablished according to the coordinates of the reference points,and then facilitate the assessment of anterior alveolar morphology using cone beam computed tomography(CBCT),sixty patients with bimaxillary protrusion were randomly selected and CBCT scans were taken.The CBCT scans were transferred to Materialism’s interactive medical image control system 10.01(MIMICS 10.01),and three dimensional models of the entire jaws were constructed.Reference points determining the reference MP were positioned in the coronal,axial,sagittal windows,and the points were exactly located by recording their coordinates in the interfaces of software.The reference MP provided high intra-observer reliability(Pearson’s r 0.992 to 0.999),and inter-observer reliability(intra-class correlation coefficients(ICCs) 0.996 to 0.999).     

Influence of HbA1c on short-term blood pressure variability in type 2 diabetic patients with diabetic nephropathy

The aim of this study was to understand the characteristics of blood pressure(BP)variability in subjects with diabetic nephropathy(DN),and identify the probable predictors affecting BP variability.Fifty-one chronic kidney disease(CKD)-hypertensive patients without diabetes(NDN group)and sixty type 2 diabetic patients with overt DN(DN group)were enrolled in this study.The values of short-term BP variability were obtained from 24 h ambulatory BP monitoring(ABPM).Variance analysis or nonparametric analysis revealed that 24-h systolic BP variability and nighttime systolic BP variability of the DN group were significantly higher than those of the NDN group[(12.23±3.66)vs.(10.74±3.83)mmHg,P<0.05;(11.23±4.82)vs.(9.48±3.69)mmHg,P<0.05].Then the patients of the DN group were divided into two groups according to glycated hemoglobin(HbA1c)level:Group A(HbA1c<7%)and Group B(HbA1c≥7%),and the t-test showed that patients in Group B had larger 24-h diastolic,daytime diastolic,and nighttime systolic/diastolic BP variability compared with Group A.In the DN group,partial correlation analysis revealed that HbA1c exhibited a strong association with 24-h diastolic,daytime diastolic,nighttime systolic and diastolic BP variability(P<0.001,P<0.001,P<0.05,and P<0.001,respectively).Taken together,larger short-term BP variability was detected in hypertensive type 2 diabetic patients with overt nephropathy and renal insufficiency.It may imply that the optimal BP variability level could benefit from a better glycaemic control.     

微型机械的前景与挑战

微型机械是一个全新的领域，从微型人造小昆虫、微型飞行器到微电子机械系统，无一不展现出奇特的功能。微型机械的前景十分诱人，但也带来了新的问题，带来了新的挑战。