Factors underlying the association of body mass index with serum ALT in Chinese hypertensive adults without known hepatic diseases

Objective:High body mass index (BMI) is considered as the most important risk factor for elevated serum alanine aminotransferase (ALT) concentration. This study examined an array of factors, including waist circumference (WC) and folate deficiency, which may mediate the association of BMI with serum ALT concentration in Chinese hypertensive adults without known hepatic diseases. Methods:A multicenter, cross-sectional study was carried out. A total of 378 patients with mild or moderate hypertension and without known hepatic diseases were recruited from five hospitals in Harbin, Shanghai, Beijing, Xi’an, and Nanjing. Results:Of the 360 hypertensive patients with complete data in our final analysis, 13.6% had high ALT concentrations (>40 IU/L). Factors including BMI, WC, triglyceride level, and folate concentration were associated with ALT concentration in univariate analysis. Consistently higher prevalence rates of elevated ALT were observed in subjects with lower folate concentrations (≥12 vs. <12 nmol/L, 9.9% vs. 17.8%, P=0.03), with higher BMI (≥28 vs. <28 kg/m2, 21.5% vs. 11.4%, P=0.02) or higher WC (≥90 vs. <90 cm, 18.5% vs. 10.0%, P=0.02). However, in multivariate analysis, the association between BMI and ALT concentration disappeared (P=0.802 in males and 0.369 in females), while WC in females (P<0.001) and folate concentration (P=0.036 in males and 0.044 in females) remained as significant predictors for ALT concentration. Conclusions:This multicenter study demonstrated that WC and low folate concentration were important factors underlying the association between BMI and ALT concentrations in Chinese hypertensive adults without known hepatic diseases.     

终身学习——少数民族妇女扫盲课程开发的一种新取向

根据时代发展,提出"终身学习"作为少数民族妇女扫盲课程开发的价值取向,并结合妇女文盲自身实际,为了实现她们的全面可持续发展,从五方面对"终身学习"的价值取向做了详细阐述:以妇女文盲的需求为基点;考虑妇女文盲全面的自我发展;融合妇女文盲自身的生活经验和社区的课程资源;注意妇女文盲创造性思维的培养;充分利用现代通信和网络信息技术。     

试论贫困学生问题的解决与和谐校园的构建

随着高校收费制度的改革,大学生中出现一个特殊的群体--贫困学生,他们面临着诸多问题.这些问题的存在,不仅关系到他们今后的成才和发展,也严重影响了和谐校园的构建.为此,我们必须高度关注和解决贫困学生问题,全面落实"以人为本"的科学发展观,努力打造温馨、舒适、愉快、稳定的校园环境,促进和谐校园的构建.     

Exponential stability for networked control systems based on the model of nonlinear discrete-time system with time-varying delay

1.IntroductionAsthecomplexityofmoderncontrolsystems,itsdimensionbecomesmoreandmorevast.Actuators,sensorsandcontrollersinsystemsareusuallydistributed.Theclose-loopfeedbackcontrolsystemscanbeestablishedviaconnectingthesenodeswithcommunicationnetwork.Thesesystemsareoftencallednetworkedcontrolsystems(NCSs).TheNCSsbasedonfieldbusnetwork,suchasCANbus,havebeenwidelyusedinvariousindustrialareasinrecentyears.Therearemanynewissueswhenusingnewsystems.Thefirstissueisthenetwork-induceddelay(sensor-to-…     

A three-level mobility management scheme for hierarchical mobile IPv6 networks

INTRODUCTION Mobile IPv6 (MIPv6) (Johnson et al., 2004) was proposed to maintain network connectivity in the next generation Internet. However, communication quality of MIPv6 degrades because of the high signaling overhead and the long signaling delay when a mobile node (MN) performs handover. Hierarchical Mobile IPv6 (HMIPv6) (Soliman et al., 2005) was proposed to improve the performance of MIPv6, where the Mobility Anchor Point (MAP) handles mobility in- side the local domain…     

Study on the expression and mutation of human telomeric repeat binding factor （hTRF1） in 10 malignant hematopoietic cell lines

Objective: Detecting the expression and mutation of human telomeric repeat binding factor (hTRF1) in 10 malignant hematopoietic cell line cells on the base of determining its genomic structure and its four pseudogenes to clarify if h TRF1 mutation is one of the factors of the activation oftelomerase. Methods: hTRF1cDNA sequences were obtained from GenBank, its genome structure and pseudogenes were forecasted by BLAST and other biology information programs and then testified by sequencing.Real-time RT-PCR was used to detect the expression ofhTRF1mRNA in 10 cell line cells, including myelogenous leukemia cell lines K562, HL-60, U-937, NB4, THP-1, HEL and Dami; lymphoblastic leukemia cell lines 6T-CEM, Jurkat and Raji. Telomerase activities of cells were detected by using telomeric repeat amplification (TRAP)-ELISA protocol. PCR and sequencing were used to detect mutation of each exon of h TRF1 in 10 cell line cells. Results: h TRF1 gene, mapped to 8q 13, was divided into 10 exons and spans 38.6 kb. Four processed pseudogenes of hTRF1 located on chromosome 13, 18, 21 and X respectively, was named as ψhTRF1-13, ψhTRF1-18, ψhTRF1-21 and ψhTRF1-X respectively. All cell line cells showed positive telomerase activity. The expression of hTRF1 was significantly lower in malignant hematopoietic cell lines cells (0.0338, 0.0108～0.0749) than in normal mononuclear cells (0.0493, 0.0369～0.128) (P=0.004). But no significant mutation was found in all exons of hTRF1 in 10 cell line cells. Four variants were found in part of intron 1,2 and 8 ofhTRF1. Their infection on gene function is unknown and needs further studies. Conclusion: hTRF1 mutation is probably not one of the main factors for telomerase activation in malignant hematopoietic disease.     

一种快速检测水稻条纹病毒的胶体金免疫层析试纸条的研制（英文）

目的:制备一种检测水稻植物和传毒介体灰飞虱中水稻条纹病毒(RSV)的胶体金免疫层析试纸条,为水稻条纹叶枯病的田间调查和检测以及预测预警提供快速、实用的检测试剂。创新点:利用制备的RSV单克隆抗体,首次制备了能在5～10 min内快速、准确、灵敏、特异地检测水稻植物和灰飞虱体内RSV的胶体金免疫层析试纸条。方法:以差速离心方法提纯的RSV病毒粒子作为免疫原免疫BALB/c小鼠,通过杂交瘤技术获得了高度特异和灵敏的RSV单克隆抗体。采用柠檬酸钠还原氯金酸的方法制备胶体金并标记一个RSV单克隆抗体,另一个RSV单克隆抗体和羊抗鼠抗体分别包被到硝酸纤维素膜的检测线和质控线,将吸水滤纸制成的样品垫、RSV免疫胶体金垫、结合有RSV单抗和羊抗鼠抗体的硝酸纤维素膜和吸水纸依次粘贴到聚氯乙烯(PVC)胶板上研制检测水稻植物和传毒介体灰飞虱中RSV的胶体金免疫层析试纸条。对田间样品进行RSV检测,分析试纸条检测RSV的有效性。结论:利用杂交瘤技术获得了2株RSV单克隆抗体(16E6和11C1),胶体金标记16E6单克隆抗体包被在聚酯膜制成的结合垫上,以11C1单克隆抗体和羊抗鼠抗体分别包被到硝酸纤维素膜的检测线和质控线,制成能在5～10 min内快速、特异、灵敏、准确地检测田间水稻及单头灰飞虱样品中RSV的胶体金免疫层析试纸条。试纸条检测感染RSV的水稻植株和灰飞虱呈阳性反应,而检测健康水稻和感染其它5种常见水稻病毒的植株及其传毒介体呈阴性反应,且试纸条检测RSV感染水稻植物组织的灵敏度达到1:20 480倍稀释(w/v, g/mL),检测携带RSV单头灰飞虱的灵敏度达到1:2560倍稀释(单头灰飞虱/μL)。田间样品检测结果发现,试纸条检测结果与反转录聚合酶链反应(RT-PCR)的检测结果一致,表明制备的试纸条可有效地用于田间RSV的检测,从而为水稻条纹叶枯病的诊断、监测预警、抗病育种、流行病学研究及科学防治提供技术和物质支撑。     

A novel mutation in CD40 ligand gene in a sporadic patient with hyper-IgM syndrome

１ＩｎｔｒｏｄｕｃｔｉｏｎＨｙｐｅｒ－ＩｇＭｓｙｎｄｒｏｍｅ（ＨＩＭ）ｉｓａｒａｒｅｉｍｍｕｎｏｄｅｆｉｃｉｅｎｃｙｃｈａｒａｃｔｅｒｉｚｅｄｂｙａｎｉｎｃｒｅａｓｅｄｓｕｓｃｅｐｔｉｂｉｌｉｔｙｔｏｒｅｃｕｒｒｅｎｔｉｎｆｅｃｔｉｏｎｓａｎｄｍａｒ...     

清末东北鼠疫的谣言传播与辟谣

近代东北鼠疫爆发期间,《盛京时报》等多家报刊对疫情进行了持续报道,然而限于信息的传播范围以及疫情的迅速蔓延,关于疫情的谣言四起,并逐渐形成较大规模,引起了民众恐慌,影响到社会的安定.为此,《盛京时报》在宣传防疫的同时,积极辟谣,引导民众正确认识鼠疫的生发机制,积极抗击疫情.随着疫情的防控和治理,民众的慌乱情绪得到安抚,...     

Reactant enrichment in hollow void of Pt NPs@MnOx nanoreactors for boosting hydrogenation performance

In confined mesoscopic spaces,the unraveling of a catalytic mechanism with complex mass transfer and adsorption processes such as reactant enrichment is a great challenge.In this study,a hollow nanoarchitecture of MnO_x-encapsulated Pt nanoparticles was designed as a nanoreactor to investigate the reactant enrichment in a mesoscopic hollow void.By employing advanced characterization techniques,we found that the reactant-enrichment behavior is derived from directional diffusion of the r...