YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths

N6-methyladenosine(m⁶A) is a critical regulator in the fate of RNA, but whether and how m⁶A executes its functions in different tissues remains largely obscure. Here we report downregulation of a crucial m⁶A reader, YTHDF2, leading to tissue-specific programmed cell deaths(PCDs) upon fluorene-9-bisphenol(BHPF) exposure. Currently, Bisphenol A(BPA) substitutes are widely used in plastic manufacturing.Interrogating eight common BPA substitutes, we detected BHPF in ...     

Photodegradable polar-functionalized polyethylenesOA

The degradation of plastics has attracted much attention from the global community.Polyethylenes(PEs),as the most abundant synthetic plastics,are most frequently studied.PE is non-degradable and non-polar because of the sole presence of the pure hydrocarbon components.Concurrent incorporation of both in-chain cleavable and functional groups into the PE chain is an effective pathway to overcome the non-degradable and non-polar issue;however,the method for achieving this pathway remains elusive.He...     

市场经济与现代行政精神

行政精神是指一个国家鼓励和倡导的,要求政府组织及其工作人员在实施公共行政管理中表现出的某些良好的心理状态和精神风貌。现代行政精神直接关系到政府形象,也直接体现党的执政能力和水平。现代行政精神是由市场经济决定的,是市场经济的必然立场。树立现代行政精神需要转变陈旧的行政观念,确立现代的行政管理理论,重视社会目的和行政管理的民主化。培养现代行政精神是全面建设小康社会的当务之急。     

大学生民族宗教政策教育现状分析及对策研究

通过对大学生民族宗教政策教育的调查发现：大学生信仰宗教的比例不高,但绝对数不少;大学生的民族意识表现出一定的理性思维和法律意识,但对问题本质认识不够;大学生对我国民族宗教政策的认可度较高,但了解程度有待深入;大学生对于国家民族宗教政策的内涵认识模糊;大学生思想政治教育工作存在薄弱环节;大学生对民族宗教的本质认识模糊,易受宗教意识渗透。通过对大学生民族宗教政策教育现状存在的问题进行分析,从高校角度出发提出了相关对策和建议：充分发挥教师在“第一课堂”中的核心作用,发挥学生在“第二课堂”中的主体作用,发挥心理健康教育的关键作用。     

疫情影响下巴彦淖尔市经济增长的对策建议

基于疫情,分析了疫情对巴彦淖尔市发展的影响,并结合巴彦淖尔市经济发展现状进行产业结构分析,提出产业结构优化升级,继续推进"天赋河套"产业集群和"沿黄生态经济带"发展的对策建议。     

Undrained anisotropy and non-coaxial behavior of clayey soil under principal stress rotation

In this study, a series of undrained tests were conducted on both intact and reconstituted clay using an automatic hollow cylinder apparatus. Monotonic shearing tests with fixed principal stress directions were carried out, pure and cyclic prin- cipal stress rotation tests were also performed. The non-coaxiality, defined as the non-coincidence of the principal plastic strain increment direction and the corresponding principal stress direction, of clayey soil was studied experimentally. The effects of the intermediate principal stress, shear stress level, and inherent anisotropy were highlighted. Clear non-coaxiality was observed during pure principal stress rotation, in both intact and reconstituted clay. The influence of the intermediate principal stress pa- rameter, shear stress level, and inherent anisotropy on the non-coaxial behavior of the clayey soil was found to be insignificant when compared with the sand. The non-coaxial behavior of the clayey soil depended more on the stress paths. Under undrained conditions, the contribution of elastic strain to the direction of the total principal strain increment cannot be ignored.     

地名入诗

“惶恐滩头说惶恐,零丁洋里叹零丁。”文天祥《过零丁洋》里的这两句诗巧妙地利用了地名的词汇意义,表达出因抗元失败而产生的惶恐、孤独之感。此后,诗句也就随着文天祥的英名而流芳百世了。     

Numerical simulation of wind flow fields around buildings using the lattice Boltzmann method

This paper presents the simulation results of the wind environment around a single high-rise building and that around two tall buildings in tandem arrangement by using the lattice Boltzmann method with an aim to understand the ventilation issues around high-rise buildings in an urban environment. We analyzed the velocity distribution around the buildings and performed numericl simulations to reveal the formation and evolution law of the complex vortex system around the high-rise buildings. Numerical simulation results manifest a periodicity phenamenon in the process of the vortex evolution. For the case of two high-rise buildings, wind velocity in the space between the two buildings is very small, which is nearly a silent regime. Wind velocity above the front building is relatively larger and the maximum wind velocity is approximately 2.5 times the incoming wind velocity. The numerical results can be used in layout planning of high-rise residential buildings to create better environment for ventilation purpose in an urban area.     

后适应在接受直接PCI治疗的急性ST段抬高性心肌梗死患者中的临床疗效:基于随机对照试验的meta分析(英文)

目的:探讨后适应对接受直接经皮冠状动脉介入(PCI)治疗的急性ST段抬高性心肌梗死(STEMI)患者心血管不良事件的影响。创新点:进一步明确后适应处理对STEMI患者临床预后的影响。方法:对符合入选标准的随机对照临床试验进行meta分析。结论:缺血后适应显著降低ST段抬高性心肌梗死患者心衰风险。